Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Sophie Couvé"'
Autor:
Stéphanie Buart, Stéphane Terry, M’boyba Khadija Diop, Philippe Dessen, Sophie Couvé, Abdérémane Abdou, Julien Adam, Jérôme Thiery, Pierre Savagner, Salem Chouaib
Publikováno v:
Cancers, Vol 13, Iss 15, p 3897 (2021)
Von Hippel–Lindau disease (VHL) is a rare hereditary syndrome due to mutations of the VHL tumor suppressor gene. Patients harboring the R167Q mutation of the VHL gene have a high risk of developing ccRCCs. We asked whether the R167Q mutation with c
Externí odkaz:
https://doaj.org/article/35e31cafab0e4e0bb8d9e40388924875
Autor:
Sonia Chelouah, Emilie Cochet, Sophie Couvé, Sandy Balkaran, Aude Robert, Evelyne May, Vasily Ogryzko, Joëlle Wiels
Publikováno v:
Cancers, Vol 10, Iss 1, p 12 (2018)
The Epstein-Barr virus nuclear antigen leader protein (EBNA-LP) acts as a co-activator of EBNA-2, a transcriptional activator essential for Epstein-Barr virus (EBV)-induced B-cell transformation. Burkitt’s lymphoma (BL) cells harboring a mutant EBV
Externí odkaz:
https://doaj.org/article/7e3b9524108041b18ef46001f909d7de
Autor:
Bernard Escudier, Jean-Jacques Patard, Sophie Gad, Sophie Couvé, Cedric Orear, Yves Allory, Vincent Molinie, Zahira Merabet, Philippe Camparo, Jean-Christophe Bernhard, Mathilde Sibony, Nathalie Rioux-Leclercq, Virginie Verkarre, Audrey Le Formal, Justine Guegan, Laurence Albiges
PDF file - 50KB, Correlation between copy number alteration (blue - gain/amplification, red - loss) and gene expression profiling. Gene expression level is represented (in grey box plot), according to copy number alteration (each blue circle represen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35cd19c2d4bca531dd0cf9158b5493e9
https://doi.org/10.1158/1078-0432.22449654.v1
https://doi.org/10.1158/1078-0432.22449654.v1
Autor:
Bernard Escudier, Jean-Jacques Patard, Sophie Gad, Sophie Couvé, Cedric Orear, Yves Allory, Vincent Molinie, Zahira Merabet, Philippe Camparo, Jean-Christophe Bernhard, Mathilde Sibony, Nathalie Rioux-Leclercq, Virginie Verkarre, Audrey Le Formal, Justine Guegan, Laurence Albiges
PDF file - 153KB, Correlation analysis of the expression level of 36 genes - involved in MET pathway - between the patients harboring a MET mutations, the 6 ccRCC samples, and normal kidney tissue samples.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebcb81ed9c82f39398e831d374e250f2
https://doi.org/10.1158/1078-0432.22449657.v1
https://doi.org/10.1158/1078-0432.22449657.v1
Autor:
Betty Gardie, Stéphane Richard, Peter Ratcliffe, William Kaelin, David R. Mole, Luba Tchertanov, Philippe Dessen, Nathalie M. Mazure, Anne-Paule Gimenez-Roqueplo, Vladimir Lazar, Jean Feunteun, Brigitte Bressac-de Paillerets, Patrick R. Benusiglio, Françoise Lasne, Christine Collin, Jean-Christophe Pagès, Bernard Lecomte, William Y. Kim, Gregory Nuel, Marion Le Gentil, Hélène Le Jeune, Sophie Gad, Justine Guégan, Karène Mahtouk, Elodie Laine, Charline Ladroue, Sophie Couvé
Table S1: Phenotypes associated with single R161Q and R200W VHL germline mutations are different from the phenotype associated with the combined mutations. Table S2: VHL mutations associated with polycythemia are different from the VHL mutations invo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12195e1a1eadc82a060397742b583b8e
https://doi.org/10.1158/0008-5472.22403115.v1
https://doi.org/10.1158/0008-5472.22403115.v1
Autor:
Betty Gardie, Stéphane Richard, Peter Ratcliffe, William Kaelin, David R. Mole, Luba Tchertanov, Philippe Dessen, Nathalie M. Mazure, Anne-Paule Gimenez-Roqueplo, Vladimir Lazar, Jean Feunteun, Brigitte Bressac-de Paillerets, Patrick R. Benusiglio, Françoise Lasne, Christine Collin, Jean-Christophe Pagès, Bernard Lecomte, William Y. Kim, Gregory Nuel, Marion Le Gentil, Hélène Le Jeune, Sophie Gad, Justine Guégan, Karène Mahtouk, Elodie Laine, Charline Ladroue, Sophie Couvé
Supplementary Material and Methods and Legend of Supplementary Tables and Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90041a881bdb670ed79fc0acd2c2f01a
https://doi.org/10.1158/0008-5472.22403121
https://doi.org/10.1158/0008-5472.22403121
Autor:
Virginie Verkarre, Sophie Couvé, Guillaume Meurice, Betty Gardie, Bin Tean Teh, Baptiste Nguyen, Flore Renaud, Stéphane Richard, Sophie Ferlicot, Bastien Job, Melanie Da Costa, Benjamin Grandon, Véronique Duchatelle, Nathalie Droin, Sophie Gad, Vincent Molinié, Katia Posseme, Gwénaël Le Teuff, Arnaud Mejean
Publikováno v:
Oncology Letters
Von Hippel-Lindau (VHL) disease is the main cause of inherited clear-cell renal cell carcinoma (ccRCC) and is caused by germline mutations in the VHL tumor suppressor gene. Bi-allelic VHL alterations lead to inactivation of pVHL, which plays a major
Autor:
Katia Posseme, Sophie Giraud, Pauline Garnier, Bastien Job, Sophie Gad, Betty Gardie, Brigitte Bressac-de Paillerets, Stéphane Richard, Flore Renaud, Nathalie Droin, Virginie Verkarre, Florine Adolphe, Sophie Ferlicot, Marc Deloger, Sophie Couvé
Publikováno v:
Cancer genetics.
Hereditary Renal Cell Carcinomas (RCC) are caused by mutations in predisposing genes, the major ones including VHL, FLCN, FH and MET. However, many families with inherited RCC have no germline mutation in these genes. Using Whole Exome Sequencing on
Autor:
Umit Aliyaskarova, Yeldar Baiken, Flore Renaud, Sophie Couve, Alexei F. Kisselev, Murat Saparbaev, Regina Groisman
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Anti-neoplastic effect of DNA cross-linking agents such as cisplatin, mitomycin C, and psoralen is attributed to their ability to induce DNA interstrand cross-links (ICLs), which block replication, transcription, and linear repair pathways b
Externí odkaz:
https://doaj.org/article/4fd03b26b5f242ecac1d2e9a6189596e
Autor:
Mathias Vilaine, Céline Garrec, Pierre Lindenbaum, Sophie Couvé, Mathilde Pacault, Laurence Heidet, Stéphane Bézieau, Celeste Bento, David Hoogewijs, Helene Dreau, Yannick Arlot-Bonnemains, Nelly Burnichon, Marion Lenglet, Richard van Wijk, Maria-Luigia Randi, Alexandre Buffet, Florence Robriquet, Fabrice Airaud, Holger Cario, Nicolas Janin, Melissa M. Pentony, Erika Kvikstad, Stéphane Richard, Karim Bouchireb, Antonis Kattamis, Jean-Michaël Mazzella, Carme Camps, Sylvie Job, Sophie Ferlicot, Anne Couturier, Richard Redon, Maria Caterina Putti, Thomas Besnard, Joachim R. Göthert, Klaus-Michael Debatin, Betty Gardie, Sophie Deveaux, Franck Chesnel, Solenne Dumont, Jenny C. Taylor, Marine Cornec, Bin Tean Teh, François Girodon, Vincent Bours, Sophie Gad, Anne-Paule Gimenez-Roqueplo, Sabine Irtan, Klaus Schwarz, Elpis Mantadakis, Samantha J. L. Knight, Brigitte Bressac-de Paillerets
Publikováno v:
Blood
Blood, 2018, 132 (5), pp.469-483. ⟨10.1182/blood-2018-03-838235⟩
Blood, American Society of Hematology, 2018, 132 (5), pp.469-483. ⟨10.1182/blood-2018-03-838235⟩
Blood, Vol. 132, no.5, p. 469-483 (2018)
Blood, 2018, 132 (5), pp.469-483. ⟨10.1182/blood-2018-03-838235⟩
Blood, American Society of Hematology, 2018, 132 (5), pp.469-483. ⟨10.1182/blood-2018-03-838235⟩
Blood, Vol. 132, no.5, p. 469-483 (2018)
International audience; Chuvash polycythemia is an autosomal recessive form of erythrocytosis associated with a homozygous p.Arg200Trp mutation in the von Hippel-Lindau (VHL) gene. Since this discovery, additional VHL mutations have been identified i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0880746e10359614471af0a533de25b
https://hal.science/hal-01833917
https://hal.science/hal-01833917