A new molecular classification to drive precision treatment strategies in primary Sjögren’s syndrome

Autor: Perrine Soret, Christelle Le Dantec, Emiko Desvaux, Nathan Foulquier, Bastien Chassagnol, Sandra Hubert, Christophe Jamin, Guillermo Barturen, Guillaume Desachy, Valérie Devauchelle-Pensec, Cheïma Boudjeniba, Divi Cornec, Alain Saraux, Sandrine Jousse-Joulin, Nuria Barbarroja, Ignasi Rodríguez-Pintó, Ellen De Langhe, Lorenzo Beretta, Carlo Chizzolini, László Kovács, Torsten Witte, PRECISESADS Clinical Consortium, PRECISESADS Flow Cytometry Consortium, Eléonore Bettacchioli, Anne Buttgereit, Zuzanna Makowska, Ralf Lesche, Maria Orietta Borghi, Javier Martin, Sophie Courtade-Gaiani, Laura Xuereb, Mickaël Guedj, Philippe Moingeon, Marta E. Alarcón-Riquelme, Laurence Laigle, Jacques-Olivier Pers

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

Sjögren’s syndrome, a disease that primarily affects women, is poorly understood. Here, the authors combine data from a large cohort of patients and healthy controls to identify biomarkers that distinguish patient subgroups to improve our understa

Externí odkaz: https://doaj.org/article/fd749685034f43a3afc45a40aaefddd7

The differentiation of prehypertrophic into hypertrophic chondrocytes drives an OA-remodeling program and IL-34 expression

Autor: G. Rolland-Valognes, Xavier Houard, Francis Berenbaum, D. Valour, G. Nourissat, D. Citadelle, L. Grégoire, M.-H. Lafage-Proust, Alain Sautet, A. Pigenet, D. Cléret, Sophie Courtade-Gaiani, S. van Eegher, I. Toillon, C. Bourrier, P. Pastoureau, S. Malbos, F. De Ceuninck, M.-L. perez-Lozano

Publikováno v: Osteoarthritis and Cartilage
Osteoarthritis and Cartilage, Elsevier, 2021, 29 (2), pp.257-268. ⟨10.1016/j.joca.2020.10.013⟩
Osteoarthritis and Cartilage, 2021, 29 (2), pp.257-268. ⟨10.1016/j.joca.2020.10.013⟩

Summary Objectives We hypothesize that chondrocytes from the deepest articular cartilage layer are pivotal in maintaining cartilage integrity and that the modification of their prehypertrophic phenotype to a hypertrophic phenotype will drive cartilag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c76d265c9e97e0de548cc58357d909a
https://pubmed.ncbi.nlm.nih.gov/33301945

Antibody-mediated neutralization of galectin-3 as a strategy for the treatment of systemic sclerosis

Autor: Céline Ortega-Ferreira, Perrine Soret, Gautier Robin, Silvia Speca, Sandra Hubert, Marianne Le Gall, Emiko Desvaux, Manel Jendoubi, Julie Saint-Paul, Loubna Chadli, Agnès Chomel, Sylvie Berger, Emmanuel Nony, Béatrice Neau, Benjamin Fould, Anne Licznar, Franck Levasseur, Thomas Guerrier, Sahar Elouej, Sophie Courtade-Gaïani, Nicolas Provost, The Quyen Nguyen, Julien Verdier, David Launay, Frédéric De Ceuninck

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)

Abstract Systemic sclerosis (SSc) is an autoimmune, inflammatory and fibrotic disease with limited treatment options. Developing new therapies is therefore crucial to address patient needs. To this end, we focused on galectin-3 (Gal-3), a lectin know

Externí odkaz: https://doaj.org/article/b4ac4a8d08c9436badd6ef4d718b8e03

Coordinate Transcriptomic and Metabolomic Effects of the Insulin Sensitizer Rosiglitazone on Fundamental Metabolic Pathways in Liver, Soleus Muscle, and Adipose Tissue in Diabetic db/db Mice

Autor: Catherine Dacquet, Catherine de Montrion, Sabrina Le Bouter, Michel Lonchampt, Manuel Brun, Claire Boursier-Neyret, Nolwen Guigal-Stephan, Vincent Croixmarie, Brian-Paul Lockhart, Thierry Umbdenstock, Marianne Rodriguez, Sophie Courtade-Gaiani, Laura Xuereb, Jean-Pierre Galizzi, Alain Ktorza

Publikováno v: PPAR Research, Vol 2010 (2010)
PPAR Research

Rosiglitazone (RSG), developed for the treatment of type 2 diabetes mellitus, is known to have potent effects on carbohydrate and lipid metabolism leading to the improvement of insulin sensitivity in target tissues. To further assess the capacity of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02ea1b8a1b175f54305c4e09deb9c0ec
https://doi.org/10.1155/2010/679184

Coordinate Transcriptomic and Metabolomic Effects of the Insulin Sensitizer Rosiglitazone on Fundamental Metabolic Pathways in Liver, Soleus Muscle, and Adipose Tissue in Diabetic db/db Mice

Autor: Sabrina Le Bouter, Marianne Rodriguez, Nolwen Guigal-Stephan, Sophie Courtade-Gaïani, Laura Xuereb, Catherine de Montrion, Vincent Croixmarie, Thierry Umbdenstock, Claire Boursier-Neyret, Michel Lonchampt, Manuel Brun, Catherine Dacquet, Alain Ktorza, Brian-Paul Lockhart, Jean-Pierre Galizzi

Publikováno v: PPAR Research, Vol 2010 (2010)

Rosiglitazone (RSG), developed for the treatment of type 2 diabetes mellitus, is known to have potent effects on carbohydrate and lipid metabolism leading to the improvement of insulin sensitivity in target tissues. To further assess the capacity of

Externí odkaz: https://doaj.org/article/46df16f6182e4c53869defeac3035f9f