Výsledky vyhledávání - "Sophie Coupa"

Crystal Structures for HIV-1 Reverse Transcriptase in Complexes with Three Pyridinone Derivatives: A New Class of Non-Nucleoside Inhibitors Effective against a Broad Range of Drug-Resistant Strains

Autor: Chi Hung Nguyen, Edward Arnold, Alain Philippe Poncelet, David Grierson, Stephen H. Hughes, Daniel M. Himmel, Said Oumouch, Christophe Meyer, Sophie Coupa, Jerome Guillemont, Abdellah Benjahad, Koen Andries, Kalyan Das, Arthur D. Clark, Csoka Imre Christian Francis

Publikováno v: Journal of medicinal chemistry

In the treatment of AIDS, the efficacy of all drugs, including non-nucleoside inhibitors (NNRTIs) of HIV-1 reverse transcriptase (RT), has been limited by the rapid appearance of drug-resistant viruses. Lys103Asn, Tyr181Cys, and Tyr188Leu are some of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83adb8b43e47995658d1595b261bb411
https://doi.org/10.1021/jm0500323

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Synthesis, Structure−Activity Relationship, and Receptor Pharmacology of a New Series of Quinoline Derivatives Acting as Selective, Noncompetitive mGlu1 Antagonists

Autor: Dominique Jean-Pierre Mabire, Alain Philippe Poncelet, Anne Simone Josephine Lesage, Ludy van Beijsterveldt, François Paul Bischoff, Ria Wouters, Christophe Adelinet, Yvan Rene Simonnet, Sophie Coupa, Marc Venet

Publikováno v: Journal of Medicinal Chemistry. 48:2134-2153

We describe the discovery and the structure-activity relationship of a new series of quinoline derivatives acting as selective and highly potent noncompetitive mGlu1 antagonists. We first identified cis-10 as a fairly potent mGlu1 antagonist (IC(50)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f7727d62ed8ca5b6fa5eb08621ef93b
https://doi.org/10.1021/jm049499o

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4-Benzyl- and 4-Benzoyl-3-dimethylaminopyridin-2(1H)-ones, a New Family of Potent Anti-HIV Agents: Optimization and in Vitro Evaluation against Clinically Important HIV Mutant Strains

Autor: Karine Courte, Marie-Pierre De Bethune, Rudi Pauwels, Jérome Guillemont, Csoka Imre Christian Francis, Chi Hung Nguyen, Alain Poncelet, Emile Bisagni, Sophie Coupa, David S. Grierson, Dominique Mabire, Abdellah Benjahad, Koen Andries, Claude Monneret

Publikováno v: Journal of medicinal chemistry

The 4-benzyl and 4-benzoyl-3-dimethylaminopyridinones 13 and 14 are representatives of a new class of highly potent non nucleoside type inhibitors of HIV-1 reverse transcriptase. To conduct SAR studies on these two lead compounds, 102 new analogues w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26af9a522cccb06a81c98206ba082c3b
https://doi.org/10.1021/jm0407658

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Synthesis and reduction of 2,2-diaryl-1-nitroethylenes by using a chiral and a non chiral NADH model in the pyrrolopyridine series

Autor: Sophie Coupa, Claude Valque, Vincent Levacher, Guy Quéguiner, Georges Dupas, Jean Bourguignon

Publikováno v: Journal of Heterocyclic Chemistry. 33:1211-1215

Reduction of 2,2-diphenyl-1-nitroethylene (1) and 2-(2-pyridyl)-2-phenyl-1-nitroethylene (5) is achieved by using the NADH model in the pyrrolopyridine series 2a to give 2,2-diphenyl-1-nitroethane (3) and 2-(2-pyridyl)-2-phenyl-1-nitroethane (7) resp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b3381c6af47424a1b5e5d15113e36889
https://doi.org/10.1002/jhet.5570330435

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ChemInform Abstract: Synthesis and Reduction of 2,2-Diaryl-1-nitroethylenes by Using a Chiral and a non Chiral NADH Model in the Pyrrolopyridine Series

Autor: Claude Valque, Guy Quéguiner, Vincent Levacher, Georges Dupas, Sophie Coupa, Jean Bourguignon

Publikováno v: ChemInform. 28

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e68decb640cf29ba250a15ee587b75c3
https://doi.org/10.1002/chin.199701177

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4-Benzyl and 4-benzoyl-3-dimethylaminopyridin-2(1H)-ones: in vitro evaluation of new C-3-amino-substituted and C-5,6-alkyl-substituted analogues against clinically important HIV mutant strains

Autor: Dominique Jean-Pierre Mabire, Koen Andries, Chi Hung Nguyen, Alain Philippe Poncelet, Martine Croisy, Daniel M. Himmel, Christophe Meyer, Claude Monneret, Eddy Arnold, R Pauwels, Marie-Pierre de Béthune, Sophie Coupa, Kalyan Das, David Grierson, Jerome Emile Georges Guillemont, Abdellah Benjahad, Csoka Imre Christian Francis, Emile Bisagni

Publikováno v: Journal of medicinal chemistry

In a program to optimize the anti-HIV activity of the 4-benzyl and 4-benzoyl-3-dimethylaminopyridinones 9 and 10, lead compounds in a new class of highly potent non-nucleoside type inhibitors of HIV-1 reverse transcriptase, modification of the alkyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::267886123a41e6a1498b86721308c0e8
https://pubmed.ncbi.nlm.nih.gov/15771439

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