Global genome decompaction leads to stochastic activation of gene expression as a first step toward fate commitment in human hematopoietic cells.

Autor: Romuald Parmentier, Laëtitia Racine, Alice Moussy, Sophie Chantalat, Ravi Sudharshan, Nan Papili Gao, Daniel Stockholm, Guillaume Corre, Geneviève Fourel, Jean-François Deleuze, Rudiyanto Gunawan, Andras Paldi

Publikováno v: PLoS Biology, Vol 20, Iss 10, p e3001849 (2022)

When human cord blood-derived CD34+ cells are induced to differentiate, they undergo rapid and dynamic morphological and molecular transformations that are critical for fate commitment. In particular, the cells pass through a transitory phase known a

Externí odkaz: https://doaj.org/article/1bf12cb102034345ac6078e5b899788a

Exome-Wide Association Study Identifies FN3KRP and PGP as New Candidate Longevity Genes

Autor: Martina Müller-Nurasyid, Markus M. Nöthen, Friederike Flachsbart, Annette Peters, Kaare Christensen, Sophie Chantalat, Stefan Schreiber, David Ellinghaus, Pilar Galan, Per Hoffmann, Almut Nebel, Lene Christiansen, Amke Caliebe, Hélène Blanché, Andre Franke, Konstantin Strauch, Marianne Nygaard, Wolfgang Lieb, Janina Dose, Guillermo G. Torres, Jean-François Deleuze

Publikováno v: Torres, G G, Nygaard, M, Caliebe, A, Blanché, H, Chantalat, S, Galan, P, Lieb, W, Christiansen, L, Deleuze, J-F, Christensen, K, Strauch, K, Müller-Nurasyid, M, Peters, A, Nöthen, M M, Hoffmann, P, Flachsbart, F, Schreiber, S, Ellinghaus, D, Franke, A, Dose, J & Nebel, A 2021, ' Exome-wide association study identifies FN3KRP and PGP as new candidate longevity genes ', The journals of gerontology. Series A, Biological sciences and medical sciences, vol. 76, no. 5, pp. 786-795 . https://doi.org/10.1093/gerona/glab023
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
J. Gerontol. A Biol. Sci. Med. Sci. 76, 786–795 (2021)

Despite enormous research efforts, the genetic component of longevity has remained largely elusive. The investigation of common variants, mainly located in intronic or regulatory regions, has yielded only little new information on the heritability of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c5a3bc1e877f0288d7b9ee198e90b2f
https://doi.org/10.1093/gerona/glab023

Comparative methylome analysis of ICF patients identifies heterochromatin loci that require ZBTB24, CDCA7 and HELLS for their methylated state

Autor: Laure Ferry, Ivana Ivkovic, Florence Ribierre, Jean-François Deleuze, Giacomo Grillo, Sophie Chantalat, Capucine Picard, Guillaume Velasco, Claire Francastel, Nizar Touleimat

Publikováno v: Human Molecular Genetics
Human Molecular Genetics, Oxford University Press (OUP), 2018, 27 (14), pp.2409-2424. ⟨10.1093/hmg/ddy130⟩
Human Molecular Genetics, 2018, 27 (14), pp.2409-2424. ⟨10.1093/hmg/ddy130⟩

Alterations of DNA methylation landscapes and machinery are a hallmark of many human diseases. A prominent case is the ICF syndrome, a rare autosomal recessive immunological/neurological disorder diagnosed by the loss of DNA methylation at (peri)cent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7891259e8e3c27045fd0e3603b60dbbb
https://hal-cea.archives-ouvertes.fr/cea-01833124

Ftx is a non-coding RNA which affects Xist expression and chromatin structure within the X-inactivation center region

Autor: Angélique Galvani, Laurent Duret, Claire Rougeulle, Antonio Romito, Sophie Chantalat, Philip Avner, Corinne Chureau

Publikováno v: Human Molecular Genetics
Human Molecular Genetics, 2011, 20, pp.705-718. ⟨10.1093/hmg/ddq516⟩
Human Molecular Genetics, Oxford University Press (OUP), 2011, 20 (4), pp.705-718. ⟨10.1093/hmg/ddq516⟩
HUMAN MOLECULAR GENETICS
HUMAN MOLECULAR GENETICS, 2011, 20, pp.705-718. ⟨10.1093/hmg/ddq516⟩

X chromosome inactivation (XCI) is an essential epigenetic process which involves several non-coding RNAs (ncRNAs), including Xist, the master regulator of X-inactivation initiation. Xist is flanked in its 5' region by a large heterochromatic hotspot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f348963dc15078e93cac57518743abf
https://univ-lyon1.hal.science/hal-02299263

Interactions between conserved domains within homodimers in the BIG1, BIG2, and GBF1 Arf guanine nucleotide exchange factors

Autor: Marie-Pierre Golinelli-Cohen, Naïma Belgareh-Touzé, Valérie Biou, Alexandra Joubert, Philip C. Simister, Jacqueline Cherfils, Odile Ramaen, Maria Conception Olivares-Sanchez, Catherine L. Jackson, Sophie Chantalat, Jean-Christophe Zeeh

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2007, 282 (39), pp.28834-42. ⟨10.1074/jbc.M705525200⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2007, ⟨10.1074/jbc.M705525200⟩
Journal of Biological Chemistry, 2007, ⟨10.1074/jbc.M705525200⟩

International audience; Guanine nucleotide exchange factors carrying a Sec7 domain (ArfGEFs) activate the small GTP-binding protein Arf, a major regulator of membrane remodeling and protein trafficking in eukaryotic cells. Only two of the seven subfa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a826485042934ec26c69650c4531868d
https://hal.archives-ouvertes.fr/hal-00200087