Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sophie Caroline Williams"'
Autor:
William R. Pitt, Verity Margaret Sabin, Andrew J. Ratcliffe, Mack Stephen, Sophie Caroline Williams, Duncan R. Hannah, Francis C. Galvin, Joanne L. Fraser, Natasha Davies, Andrew Sharpe, Kerry Jenkins, George M. Buckley, Marianna D. Richard, Alan Findlay Haughan, Rebekah Beevers
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:2539-2542
The elaboration of previously reported indole fragments as inhibitors of inosine monophosphate dehydrogenase (IMPDH) is described. The synthesis, in vitro inhibitory values for IMPDH II, PBMC proliferation and physicochemical properties are discussed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9acd9b8b5a2c42d29d74244bcd988a41
https://doi.org/10.1016/j.bmcl.2006.01.090
https://doi.org/10.1016/j.bmcl.2006.01.090
Autor:
Justine M. Whitworth, Alicia J. Taylor, Sophie Caroline Williams, Alan Findlay Haughan, Philip J. Gilbert, Duncan R. Hannah, George M. Buckley, Natasha Davies, Rachael Profit, William R. Pitt, Hazel Joan Dyke, Caroline A. Hunt, Marianna D. Richard, Nicholas C. Ray, Andrew Sharpe
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:751-754
The development of a series of novel quinazolinethiones and quinazolinediones as inhibitors of inosine monophosphate dehydrogenase (IMPDH) is described. The synthesis, in vitro inhibitory values for IMPDH II and in vitro inhibitory value for PBMC pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::836874af7b31b9fc5782f3b758df37a8
https://doi.org/10.1016/j.bmcl.2004.11.015
https://doi.org/10.1016/j.bmcl.2004.11.015
Autor:
Simon A. Osborne, Sophie Caroline Williams, Nicola E.A. Chessum, Mark J. Field, Natasha Kinsella, Pauline Carnell, Jack K. Kinsora, David C. Blakemore, Justin Stephen Bryans
Publikováno v:
ChemInform. 41
A range of 3-alkylated five-membered ring derivatives of Gabapentin were synthesized and several were found to have good levels of potency against the α2δ calcium subunit of a voltage-gated calcium channel. Two compounds were profiled in in vivo mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed4af07717ef574cf5a76d408348a934
https://doi.org/10.1002/chin.201021062
https://doi.org/10.1002/chin.201021062
Autor:
Jack K. Kinsora, Lisa R. Thompson, Pauline Carnell, Mark J. Field, Natasha Kinsella, Justin Stephen Bryans, Sophie Caroline Williams, Simon A. Osborne, David C. Blakemore, Leonard T. Meltzer
Publikováno v:
ChemInform. 41
A range of 3,4-alkylated five-membered ring derivatives of gabapentin were synthesised. One compound (21) had an excellent level of potency against alpha(2)delta and was profiled in in vivo models of pain and anxiety.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c4faaf5604decc4e73dc9001e210902
https://doi.org/10.1002/chin.201021061
https://doi.org/10.1002/chin.201021061
Autor:
Justin Stephen Bryans, David C. Blakemore, Simon A. Osborne, Andrew N. Warren, Pauline Carnell, Natasha Kinsella, Sophie Caroline Williams, Nicola E.A. Chessum, Christopher L. Carr, Mark J. Field
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(2)
Synthesis of a number of bicyclic five-membered ring derivatives of gabapentin led to the identification of two compounds, (−)-(11A) and (20A) which both had an excellent level of potency against α2δ and were profiled in an in vivo model of neuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75b555ffed073e7ca0a441ec5e587197
https://pubmed.ncbi.nlm.nih.gov/20005103
https://pubmed.ncbi.nlm.nih.gov/20005103
Autor:
Pauline Carnell, David C. Blakemore, Natasha Kinsella, Mark J. Field, Jack K. Kinsora, Simon A. Osborne, Sophie Caroline Williams, Nicola E.A. Chessum, Justin Stephen Bryans
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(1)
A range of 3-alkylated five-membered ring derivatives of Gabapentin were synthesized and several were found to have good levels of potency against the alpha2delta calcium subunit of a voltage-gated calcium channel. Two compounds were profiled in in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac414b7b5f51c10c99d30887b303ce20
https://pubmed.ncbi.nlm.nih.gov/19897364
https://pubmed.ncbi.nlm.nih.gov/19897364
Autor:
Christopher James Lock, David Alan Owen, Robert John Watson, Daniel Rees Allen, Helen L. Birch, Louise A. Jopling, Roland L. Knight, Gilles Raphy, Sophie Caroline Williams, Frances C.A. Galvin, Johannes W.G. Meissner, Gayle A. Chapman
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(2)
The synthesis and biological evaluation of a novel series of 2-aminoquinoline substituted piperidines and tropanes incorporating a homotropene moiety is herein described. The series exhibits potent antagonism of the CXCR3 receptor and superior physic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e418a4a1be65f386c4fdf59bafda8a7
https://pubmed.ncbi.nlm.nih.gov/18068363
https://pubmed.ncbi.nlm.nih.gov/18068363
Autor:
Andrew J. Ratcliffe, Michael J. Madigan, William R. Pitt, Justine M. Whitworth, Duncan R. Hannah, Philip J. Gilbert, Marianna D. Richard, Alicia J. Taylor, Elizabeth J. Frost, Andrew Sharpe, George M. Buckley, Sophie Caroline Williams, Nicholas C. Ray, Trevor Morgan, Alan Findlay Haughan, Helen L. Birch, Hazel Joan Dyke, Natasha Davies
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(23)
The synthesis and biological activity of a novel series of 7-methoxy-6-oxazol-5-yl-2,3-dihydro-1H-quinazolin-4-ones are described. Some of these compounds were found to be potent inhibitors of inosine 5'-monophosphate dehydrogenase type II (IMPDH II)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ee7e970dddfb4b40069bfc750253f5
https://pubmed.ncbi.nlm.nih.gov/16202581
https://pubmed.ncbi.nlm.nih.gov/16202581