Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Sophie C. Joosten"'
Autor:
Manon van Engeland, Wim Van Criekinge, Fred T. Bosman, Maureen J. Aarts, James G. Herman, Nita Ahuja, Kornel E. Schuebel, Joo Mi Yi, Jana Jeschke, Piet A. van den Brandt, Leo J. Schouten, Marcella M.L.L. Baldewijns, Veerle Melotte, Leander Van Neste, Kim M. Smits, Tim De Meyer, Sophie C. Joosten, Iris J.H. van Vlodrop
File containing Supplementary Tables S1-S7 and Legends to Supplementary Figures S1-S4. Supplementary Table S1. Primers for promoter methylation analysis by MSP of the 43 candidate genes. Supplementary Table S2. Primers for mRNA expression analysis by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88997b95ae7fcd8f0ac348962fa8ee51
https://doi.org/10.1158/1078-0432.22467273.v1
https://doi.org/10.1158/1078-0432.22467273.v1
Autor:
Manon van Engeland, Wim Van Criekinge, Fred T. Bosman, Maureen J. Aarts, James G. Herman, Nita Ahuja, Kornel E. Schuebel, Joo Mi Yi, Jana Jeschke, Piet A. van den Brandt, Leo J. Schouten, Marcella M.L.L. Baldewijns, Veerle Melotte, Leander Van Neste, Kim M. Smits, Tim De Meyer, Sophie C. Joosten, Iris J.H. van Vlodrop
Supplementary Figure S2. Validation of up-regulation of gene expression after demethylation with DAC by qRT-PCR for 22 genes. Relative mRNA expression of 22 genes analyzed by qRT-PCR in ccRCC cell lines SKRC1, SKRC52 and SKRC59 treated with either mo
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https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a0576560c47e633d1b2cb7d97d0ea64
https://doi.org/10.1158/1078-0432.22467267
https://doi.org/10.1158/1078-0432.22467267
Autor:
Manon van Engeland, Wim Van Criekinge, Fred T. Bosman, Maureen J. Aarts, James G. Herman, Nita Ahuja, Kornel E. Schuebel, Joo Mi Yi, Jana Jeschke, Piet A. van den Brandt, Leo J. Schouten, Marcella M.L.L. Baldewijns, Veerle Melotte, Leander Van Neste, Kim M. Smits, Tim De Meyer, Sophie C. Joosten, Iris J.H. van Vlodrop
Supplementary Figure S3. Cause-specific overall survival curves for candidate genes in hospital-based ccRCC series (related to Supplementary Table S5). Kaplan-Meier curves of CSPG4 (A), KRT7 (B), QPCT (C), RGMA (D), and SORL1 (E) analyzed for overall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::692055e6ee85aeda0037cd74e8a5f433
https://doi.org/10.1158/1078-0432.22467264
https://doi.org/10.1158/1078-0432.22467264
Autor:
Manon van Engeland, Wim Van Criekinge, Fred T. Bosman, Maureen J. Aarts, James G. Herman, Nita Ahuja, Kornel E. Schuebel, Joo Mi Yi, Jana Jeschke, Piet A. van den Brandt, Leo J. Schouten, Marcella M.L.L. Baldewijns, Veerle Melotte, Leander Van Neste, Kim M. Smits, Tim De Meyer, Sophie C. Joosten, Iris J.H. van Vlodrop
Purpose: The currently used prognostic models for patients with nonmetastatic clear cell renal cell carcinoma (ccRCC) are based on clinicopathologic features and might be improved by adding molecular markers. Epigenetic alterations occur frequently i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::088603be11d6b08e179b3c5e31137c16
https://doi.org/10.1158/1078-0432.c.6526593.v1
https://doi.org/10.1158/1078-0432.c.6526593.v1
Autor:
Manon van Engeland, Wim Van Criekinge, Fred T. Bosman, Maureen J. Aarts, James G. Herman, Nita Ahuja, Kornel E. Schuebel, Joo Mi Yi, Jana Jeschke, Piet A. van den Brandt, Leo J. Schouten, Marcella M.L.L. Baldewijns, Veerle Melotte, Leander Van Neste, Kim M. Smits, Tim De Meyer, Sophie C. Joosten, Iris J.H. van Vlodrop
Supplementary Figure S1. Methylation analysis of GREM1, LAD1, NEFH and NEURL by methylation-specific PCR (MSP) in the hospital- and population-based series and in the TCGA series. A. Schematic representation of the CpG island promoter region of the f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c2d2f980dc271fec6182d6a7033bc7
https://doi.org/10.1158/1078-0432.22467270
https://doi.org/10.1158/1078-0432.22467270
Autor:
M. van Engeland, Leo J. Schouten, N. Buekers, Sophie C. Joosten, Alexander Koch, Maureen J.B. Aarts, S. M. J. van Kuijk, Vivianne C. G. Tjan-Heijnen, P.A. van den Brandt, L. Van Neste, Marcella Baldewijns, Selena Odeh, Kim M. Smits
Publikováno v:
Clinical epigenetics, 13(1):103. BioMed Central Ltd
Clinical Epigenetics
Clinical Epigenetics
Background Current risk models for renal cell carcinoma (RCC) based on clinicopathological factors are sub-optimal in accurately identifying high-risk patients. Here, we perform a head-to-head comparison of previously published DNA methylation marker
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e42924360c9be296eccd8a28149f4a3
https://lirias.kuleuven.be/handle/123456789/684974
https://lirias.kuleuven.be/handle/123456789/684974
Autor:
Sophie C. Joosten, Joep G. H. van Roermund, Ivette A. G. Deckers, Manon van Engeland, Kim M. Smits, Veerle Melotte, Maureen J.B. Aarts, Vivianne C. G. Tjan-Heijnen, Ann Hoeben
Publikováno v:
Epigenomics. 9:1243-1257
Aim: Despite numerous published prognostic methylation markers for renal cell carcinoma (RCC), none of these have yet changed patient management. Our aim is to systematically review and evaluate the literature on prognostic DNA methylation markers fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a05049941a50dbb6b586c99f32b7fa7
https://doi.org/10.2217/epi-2017-0040
https://doi.org/10.2217/epi-2017-0040
Autor:
Kim M. Smits, Vivianne C. G. Tjan-Heijnen, Maureen J.B. Aarts, Alexander Koch, Veerle Melotte, Manon van Engeland, Sophie C. Joosten
Publikováno v:
Nature reviews. Urology. 15(7)
Renal cell carcinoma (RCC) is characterized by an infrequent number of somatic mutations. By contrast, epigenetic aberrations are commonly found in RCC, indicating that epigenetic reprogramming is an important event in RCC development. Epigenetic alt
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https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77680988d8c280e90c9bb4f41a5a7bf9
https://pubmed.ncbi.nlm.nih.gov/29867106
https://pubmed.ncbi.nlm.nih.gov/29867106
Autor:
Tim De Meyer, Muriel X. G. Draht, James G. Herman, Tim C. de Ruijter, Sophie C. Joosten, Alexander Koch, Manon van Engeland, Wim Van Criekinge, Veerle Melotte, Zheng Feng, Leander Van Neste, Jürgen Veeck, Kim M. Smits
Publikováno v:
Nature Reviews Clinical Oncology, 15(7), 459-466. Nature Publishing Group
Changes in DNA methylation in cancer have been heralded as promising targets for the development of powerful diagnostic, prognostic, and predictive biomarkers. Despite the existence of more than 14,000 scientific publications describing DNA methylati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d13b0c345abb159b5552cae0a720a9d
https://pubmed.ncbi.nlm.nih.gov/29713045
https://pubmed.ncbi.nlm.nih.gov/29713045
Autor:
Kornel E. Schuebel, Sophie C. Joosten, Tim De Meyer, Jana Jeschke, Nita Ahuja, Leander Van Neste, Leo J. Schouten, Fred T. Bosman, Veerle Melotte, Kim M. Smits, Piet A. van den Brandt, Wim Van Criekinge, Marcella M. Baldewijns, Manon van Engeland, Maureen J.B. Aarts, Iris J. H van Vlodrop, James G Herman, Joo Mi Yi
Publikováno v:
Clinical Cancer Research, 23(8), 2006-2018. American Association for Cancer Research Inc.
Purpose: The currently used prognostic models for patients with nonmetastatic clear cell renal cell carcinoma (ccRCC) are based on clinicopathologic features and might be improved by adding molecular markers. Epigenetic alterations occur frequently i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffc9b9659c1d428f5e1afd61d1c703e7
https://cris.maastrichtuniversity.nl/en/publications/ec3010df-9742-417a-8d50-70dfff3e40e4
https://cris.maastrichtuniversity.nl/en/publications/ec3010df-9742-417a-8d50-70dfff3e40e4