Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Sophie Braga Lagache"'
Autor:
Joanna Cyrta, Anke Augspach, Maria Rosaria De Filippo, Davide Prandi, Phillip Thienger, Matteo Benelli, Victoria Cooley, Rohan Bareja, David Wilkes, Sung-Suk Chae, Paola Cavaliere, Noah Dephoure, Anne-Christine Uldry, Sophie Braga Lagache, Luca Roma, Sandra Cohen, Muriel Jaquet, Laura P. Brandt, Mohammed Alshalalfa, Loredana Puca, Andrea Sboner, Felix Feng, Shangqian Wang, Himisha Beltran, Tamara Lotan, Martin Spahn, Marianna Kruithof-de Julio, Yu Chen, Karla V. Ballman, Francesca Demichelis, Salvatore Piscuoglio, Mark A. Rubin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The differentiation of prostate adenocarcinoma to neuroendocrine prostate cancer (CRPC-NE) is a mechanism of resistance to androgen deprivation therapy. Here the authors show that SWI/SNF chromatin-remodeling complex is deregulated in CRPC-NE and tha
Externí odkaz:
https://doaj.org/article/b36e0ab4d6324855a87fa9ba1ed5cc3e
Autor:
Philip V'kovski, Markus Gerber, Jenna Kelly, Stephanie Pfaender, Nadine Ebert, Sophie Braga Lagache, Cedric Simillion, Jasmine Portmann, Hanspeter Stalder, Véronique Gaschen, Rémy Bruggmann, Michael H Stoffel, Manfred Heller, Ronald Dijkman, Volker Thiel
Publikováno v:
eLife, Vol 8 (2019)
Positive-sense RNA viruses hijack intracellular membranes that provide niches for viral RNA synthesis and a platform for interactions with host proteins. However, little is known about host factors at the interface between replicase complexes and the
Externí odkaz:
https://doaj.org/article/7bc36cf2cef34b898f15cc0116f17a65
Autor:
Joachim Müller, Ghalia Boubaker, Norbert Müller, Anne-Christine Uldry, Sophie Braga-Lagache, Manfred Heller, Andrew Hemphill
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 6903 (2024)
Identification of drug targets and biochemical investigations on mechanisms of action are major issues in modern drug development. The present article is a critical review of the classical “one drug”—“one target” paradigm. In fact, novel me
Externí odkaz:
https://doaj.org/article/41f5aa8b01e94ed9b1d47e8e3532f780
Autor:
Joachim Müller, Carling Schlange, Manfred Heller, Anne-Christine Uldry, Sophie Braga-Lagache, Richard K. Haynes, Andrew Hemphill
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 21, Iss , Pp 1-12 (2023)
The sesquiterpene lactone artemisinin and its amino-artemisinin derivatives artemiside (GC008) and artemisone (GC003) are potent antimalarials. The mode of action of artemisinins against Plasmodium sp is popularly ascribed to 'activation' of the pero
Externí odkaz:
https://doaj.org/article/ab6fe9874f28493880edaf6ef7fc235c
Autor:
Kai Pascal Alexander Hänggeli, Andrew Hemphill, Norbert Müller, Manfred Heller, Anne-Christine Uldry, Sophie Braga-Lagache, Joachim Müller, Ghalia Boubaker
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 10454 (2023)
In T. gondii, as well as in other model organisms, gene knock-out using CRISPR-Cas9 is a suitable tool to identify the role of specific genes. The general consensus implies that only the gene of interest is affected by the knock-out. Is this really t
Externí odkaz:
https://doaj.org/article/ba16f7ca331549b4b4fc3de477bc1ccb
Autor:
Joachim Müller, Ghalia Boubaker, Dennis Imhof, Kai Hänggeli, Noé Haudenschild, Anne-Christine Uldry, Sophie Braga-Lagache, Manfred Heller, Luis-Miguel Ortega-Mora, Andrew Hemphill
Publikováno v:
Biomedicines, Vol 10, Iss 11, p 2675 (2022)
Leucinostatins are antimicrobial peptides with a broad range of activities against infectious agents as well as mammalian cells. The leucinostatin-derivative peptide ZHAWOC_6027 (peptide 6027) was tested in vitro and in vivo for activity against the
Externí odkaz:
https://doaj.org/article/2ba88df426664e6781b75855c7acd0f4
Autor:
Boubaker, Kai Pascal Alexander Hänggeli, Andrew Hemphill, Norbert Müller, Manfred Heller, Anne-Christine Uldry, Sophie Braga-Lagache, Joachim Müller, Ghalia
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 13; Pages: 10454
In T. gondii, as well as in other model organisms, gene knock-out using CRISPR-Cas9 is a suitable tool to identify the role of specific genes. The general consensus implies that only the gene of interest is affected by the knock-out. Is this really t
Autor:
Jovana Jankovic, Sophie Braga-Lagache, Cedric Simillion, Nicolas Bonadies, Manfred Heller, Rémy Bruggmann, Ramanjaneyulu Allam, Anne-Christine Uldry, Mahmoud Hallal
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-15 (2021)
Hallal, Mahmoud; Braga-Lagache, Sophie; Jankovic, Jovana; Simillion, Cedric; Bruggmann, Rémy; Uldry, Anne-Christine; Allam, Ramanjaneyulu; Heller, Manfred; Bonadies, Nicolas (2021). Inference of kinase-signaling networks in human myeloid cell line models by Phosphoproteomics using kinase activity enrichment analysis (KAEA). BMC cancer, 21(1), p. 789. BioMed Central 10.1186/s12885-021-08479-z
BMC Cancer
Hallal, Mahmoud; Braga-Lagache, Sophie; Jankovic, Jovana; Simillion, Cedric; Bruggmann, Rémy; Uldry, Anne-Christine; Allam, Ramanjaneyulu; Heller, Manfred; Bonadies, Nicolas (2021). Inference of kinase-signaling networks in human myeloid cell line models by Phosphoproteomics using kinase activity enrichment analysis (KAEA). BMC cancer, 21(1), p. 789. BioMed Central 10.1186/s12885-021-08479-z
BMC Cancer
Background Despite the introduction of targeted therapies, most patients with myeloid malignancies will not be cured and progress. Genomics is useful to elucidate the mutational landscape but remains limited in the prediction of therapeutic outcome a
Autor:
Heller, Anne-Christine Uldry, Anabel Maciel-Dominguez, Maïwenn Jornod, Natasha Buchs, Sophie Braga-Lagache, Justine Brodard, Jovana Jankovic, Nicolas Bonadies, Manfred
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 9; Pages: 4515
Circulating extracellular vesicles (cEV) are released by many kinds of cells and play an important role in cellular communication, signaling, inflammation modulation, coagulation, and tumor growth. cEV are of growing interest, not only as biomarkers,
Autor:
Anne-Christine, Uldry, Anabel, Maciel-Dominguez, Maïwenn, Jornod, Natasha, Buchs, Sophie, Braga-Lagache, Justine, Brodard, Jovana, Jankovic, Nicolas, Bonadies, Manfred, Heller
Publikováno v:
International journal of molecular sciences. 23(9)
Circulating extracellular vesicles (cEV) are released by many kinds of cells and play an important role in cellular communication, signaling, inflammation modulation, coagulation, and tumor growth. cEV are of growing interest, not only as biomarkers,