Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Sophie Botta Gordon-Smith"'
Autor:
Jane Harper, Katherine J Adams, Giovanna Bossi, Debbie E Wright, Andrea R Stacey, Nicole Bedke, Ruth Martinez-Hague, Dan Blat, Laure Humbert, Hazel Buchanan, Gabrielle S Le Provost, Zoe Donnellan, Ricardo J Carreira, Samantha J Paston, Luise U Weigand, Martina Canestraro, Joseph P Sanderson, Sophie Botta Gordon-Smith, Kate L Lowe, Karolina A Rygiel, Alex S Powlesland, Annelise Vuidepot, Namir J Hassan, Brian J Cameron, Bent K Jakobsen, Joseph Dukes
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205491 (2018)
Robust preclinical testing is essential to predict clinical safety and efficacy and provide data to determine safe dose for first-in-man studies. There are a growing number of examples where the preclinical development of drugs failed to adequately p
Externí odkaz:
https://doaj.org/article/c3d7165394b5442098ed39f7073a5fbd
Autor:
Debbie E. Wright, Bent K. Jakobsen, Tomasz Dobrzycki, Ruth Martinez-Hague, Luise U. Weigand, Ana Ribeiro, Nicole Bedke, Jane Harper, Sophie Botta Gordon-Smith, Samantha Paston, Laure Humbert, Dan Blat, Joseph Dukes, Andrea Stacey, Giovanna Bossi, Zoe Donellan, Martina Canestraro
Publikováno v:
Cancer Immunology Research. 7:A214-A214
Immune Mobilising Monoclonal TCRs Against Cancer (ImmTAC) molecules are a new class of bi-specific biologic specifically designed to recognize and eradicate cancer cells. ImmTAC molecules are composed of an affinity-enhanced T-cell receptor (TCR) fus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81fc78f248c4e5df91924dae9529c039
https://doi.org/10.1158/2326-6074.cricimteatiaacr18-a214
https://doi.org/10.1158/2326-6074.cricimteatiaacr18-a214
Publikováno v:
Pediatric Rheumatology Online Journal
The nucleoside adenosine exerts regulatory functions prompting T cell anergy and preventing release of inflammatory cytokines. The main source of extracellular adenosine is AMP dephosphorylated by CD73. The resulting product can be taken up by the ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb6701ff790fe83771d386c0e7463e2
http://europepmc.org/articles/PMC4191740
http://europepmc.org/articles/PMC4191740