Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Sophie Basler"'
Publikováno v:
Journal of the American Chemical Society. 143:2736-2740
Nonribosomal peptides (NRPs) are a therapeutically important class of secondary metabolites that are produced by modular synthetases in assembly-line fashion. We previously showed that a single Trp-to-Ser mutation in the initial Phe-loading adenylati
Autor:
Anna Camus, Donald Hilvert, Takahiro Mori, Yike Zou, Roger C. Helgeson, H. Adrian Bunzel, Gonzalo Jiménez-Osés, Sophie Basler, Sabine Studer, Yusuke Ota, K. N. Houk
Publikováno v:
Nature Chemistry. 13:231-235
New enzyme catalysts are usually engineered by repurposing the active sites of natural proteins. Here we show that design and directed evolution can be used to transform a non-natural, functionally naive zinc-binding protein into a highly active cata
Autor:
Sarah L. Lovelock, Rebecca Crawshaw, Sophie Basler, Colin Levy, David Baker, Donald Hilvert, Anthony P. Green
Publikováno v:
Nature. 606(7912)
The ability to design efficient enzymes from scratch would have a profound effect on chemistry, biotechnology and medicine. Rapid progress in protein engineering over the past decade makes us optimistic that this ambition is within reach. The develop
Autor:
Marc A. Gauthier, Hajo Kries, Jean-Christophe Leroux, Donald Hilvert, Jessica D. Schulz, Sophie Basler, Melanie Patt
Publikováno v:
ADVANCED MATERIALS
The site-specific conjugation of polymers to multiple engineered cysteine residues of a prolyl endopeptidase leads to its stabilization in the gastrointestinal tract of rats, without compromising the activity relative to the native enzyme. The import