Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sophie B. Sun"'
Publikováno v:
Journal of the American Chemical Society. 140(5)
The monoclonal antibody 48G7 differs from its germline precursor by ten somatic mutations, a number of which appear to be functionally silent. We analyzed the effects of individual somatic mutations and combinations thereof on both antibody binding a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c94eb2ae02045f583623f50629deca9
https://pubmed.ncbi.nlm.nih.gov/23795814
https://pubmed.ncbi.nlm.nih.gov/23795814
Publikováno v:
ChemBioChem. 15:1721-1729
To date, over 100 noncanonical amino acids (ncAAs) have been genetically encoded in living cells in order to expand the functional repertoire of the canonical 20 amino acids. More recently, this technology has been expanded to the field of protein th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18b31fb3cee732f5f98eac389ce6f52a
https://doi.org/10.1002/cbic.201402154
https://doi.org/10.1002/cbic.201402154
Autor:
Vaughn V. Smider, Erik D. Wold, Mingchao Kang, Sei-hyun Choi, Jennifer L. Furman, Peter G. Schultz, Chan Hyuk Kim, Sophie B. Sun, Yu Cao
Publikováno v:
Journal of the American Chemical Society
Selective covalent bond formation at a protein-protein interface potentially can be achieved by genetically introducing into a protein an appropriately "tuned" electrophilic unnatural amino acid that reacts with a native nucleophilic residue in its c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dff00d8d5d862b14b1d0b801354083d
https://doi.org/10.1021/ja502851h
https://doi.org/10.1021/ja502851h
Publikováno v:
Journal of the American Chemical Society. 135:9980-9983
The monoclonal antibody 48G7 differs from its germline precursor by 10 somatic mutations, a number of which appear to be functionally silent. We analyzed the effects of individual somatic mutations and combinations thereof on both antibody binding af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e38f276162ebf7316bc0ff37f9971b29
https://doi.org/10.1021/ja402927u
https://doi.org/10.1021/ja402927u
Autor:
Lorenzo de Lichtervelde, Sophie B. Sun, Vaughn V. Smider, Yong Zhang, Danling Wang, Feng Wang, Peter G. Schultz
Publikováno v:
Angewandte Chemie International Edition. 52:8295-8298
Most mammalian antibodies have complementarity determining region (CDR) loops of 8–16 residues, while some human antibodies have longer, protruding CDR loops that play a role in virus neutralization.[1] The bovine antibody repertoire features a sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d0c214adc0b15f9ce111cf08318f02d
https://doi.org/10.1002/anie.201303656
https://doi.org/10.1002/anie.201303656
Autor:
Yong Zhang, Danling Wang, Lorenzo de Lichtervelde, Sophie B. Sun, Vaughn V. Smider, Peter G. Schultz, Feng Wang
Publikováno v:
Angewandte Chemie. 125:8453-8456
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9e848e6beddb191cda3407849cc1c1e
https://doi.org/10.1002/ange.201303656
https://doi.org/10.1002/ange.201303656
Publikováno v:
Biochemistry. 52:1828-1837
To site-specifically incorporate an unnatural amino acid (UAA) into target proteins in Escherichia coli, we use a suppressor plasmid that provides an engineered suppressor tRNA and an aminoacyl-tRNA synthetase (aaRS) specific for the UAA of interest.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70e32386b3a883b350af70c085dae420
https://doi.org/10.1021/bi4000244
https://doi.org/10.1021/bi4000244
Autor:
Travis S. Young, Sophie B. Sun, Holly Pugh, Hwayoung Yun, Timothy M. Wright, Stephanie A. Kazane, Chan Hyuk Kim, Ji Young Kim, James N. Kochenderfer, Peter G. Schultz, Bryan R. Fonslow, Jennifer S. Y. Ma, Min Soo Kim, Sei-hyun Choi, Oded Singer, David T. Rodgers, Yu Cao
Publikováno v:
Proceedings of the National Academy of Sciences. 113
The adoptive transfer of autologous T cells engineered to express a chimeric antigen receptor (CAR) has emerged as a promising cancer therapy. Despite impressive clinical efficacy, the general application of current CAR-T--cell therapy is limited by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18b4f8dddb846c9d86054a48f6d4ab4d
https://doi.org/10.1073/pnas.1524193113
https://doi.org/10.1073/pnas.1524193113