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Chelatable cellular copper modulates differentiation and self-renewal of cord blood-derived hematopoietic progenitor cells

Autor: Eitan Fibach, Sophie Adi, Harel Assor, Toni Peled, Elina Glukhman, Julie Mandel, Arnon Nagler, Efrat Landau, Nira Hasson, Chana Landor, Eugenia Prus, Dima Yudin

Publikováno v: Experimental hematology. 33(10)

Objectives We have demonstrated epigenetic modulation of CD34 + cell differentiation by the high-affinity copper (Cu) chelator tetraethylenepentamine (TEPA). TEPA slowed down the rate of CD34 + cell differentiation and increased their engraftability

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6850626bd662d5fa4fe7c2c4a96d4bc
https://pubmed.ncbi.nlm.nih.gov/16219531

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123: Increased Expansion, Homing and Engraftment of Cytokine-Cultured Cord Blood-Derived CD34+ Cells by Treatment with Nicotinamide, a form of Vitamin B3

Autor: Sophie Adi, Tony Peled, Ninette Amariglio, Amnon Peled, G. Rechavi, Eitan Fibach, Yaron Daniely, Hadas Shoham, J.J. Hirsch, Arnon Nagler, N.G. Rosenheimer

Publikováno v: Biology of Blood and Marrow Transplantation. 14:47

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c4e7034af354e2b4a5c01ec4190a1b4
https://doi.org/10.1016/j.bbmt.2007.12.132

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Nicotinamide Modulates Ex-Vivo Expansion of Cord Blood Derived CD34+ Cells Cultured with Cytokines and Promotes Their Homing and Engraftment in SCID Mice

Autor: Sophie Adi, N.G. Rosenheimer, Iddo Peleg, Eitan Fibach, Arnon Nagler, Yaron Daniely, Tony Peled, Amnon Peled

Publikováno v: Blood. 108:725-725

Nicotinamide (NA) is a non-competitive inhibitor of NAD(+)-dependent ADP-ribosyl transferases, of CD38 NADase (a major regulator of cellular NAD levels) and of Sir2 histone-deacetylase. These enzymes are playing a pivotal role in regulation of signal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::16137791e1994e73464bc4f6532aef0e
https://doi.org/10.1182/blood.v108.11.725.725

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Antagonists to Retinoid Receptors Down-Regulate CD38 Expression and Inhibit In Vitro Differentiation of Cord Blood Derived CD34+ Cells

Autor: Tony Peled, Sophie Adi, Efrat Landau, Chana Lador, Eitan Fibach, Julie Mandel, Nira Hasson, Ela Glukhman

Publikováno v: Blood. 108:3652-3652

CD38, originally described as a differentiation marker, has emerged as an important multifunctional protein. Its most well-characterized function is the ability to catalyze the synthesis of cyclic ADP-ribose (cADPR) from NAD. However, its major enzym

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a68904d3e91cb590752514eb438c848
https://doi.org/10.1182/blood.v108.11.3652.3652

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Cord Blood Derived CD34+ and AC133+ Progenitor Cells Ex-Vivo Expanded in the Presence of Tetraethylenepentamine: Reproducibility among Cord Blood Units

Autor: Nira Hasson, A. Hasson, Sophie Adi, Arnon Nagler, Elina Glukhman, Yaron Daniely, Dorit Harati, A. Harel, Tony Peled, N. Rosenheimer-Goudsmid, Esti Olesinski, Frida Grynspan, Efrat Landau, Julie Mandel, D. Yudin, Elizabeth J. Shpall, Eitan Fibach, L. Hana

Publikováno v: Blood. 104:405-405

Ex-vivo expansion strategies of cord blood (CB) derived human progenitor cells (HPC) have been developed to provide an answer to the delayed time to engraftment and to the extended periods of neutropenia and thrombocytopenia encountered. These proble

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c43c9ea385fc5a74d213e97e354ed335
https://doi.org/10.1182/blood.v104.11.405.405

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Cell Cycle Progression and Self-Renewal Divisions of Cord Blood Derived CD34+ Cells Treated with the Polyamine Copper-Chelator Tetraethylenepentamine

Autor: Sophie Adi, Toni Peled, Noga R. Goudsmid, Arnon Nagler, Frida Grynspan, Efrat Landau, Eitan Fibach, Yaron Daniely

Publikováno v: Blood. 104:4237-4237

In vitro cell expansion is constrained by default pathways of commitment and differentiation resulting in limited expansion of hematopoietic stem-progenitor cells (HSPCs). Still, several ex vivo manipulations have been reported to achieve expansion o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::acbe7de795f26340025bcb086fa6eedf
https://doi.org/10.1182/blood.v104.11.4237.4237

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Nicotinamide, a Potent SIRT2 Inhibitor, Delays Differentiation of Hematopoietic Progenitor Cells

Autor: Sophie Adi, Eitan Fibach, Frida Grynspan, Yaron Daniely, Elina Glukhman, Toni Peled, Arnon Nagler

Publikováno v: Blood. 104:4142-4142

CD38, originally described as a differentiation marker, has emerged as an important multifunctional transmembrane protein. Its most intriguing and well-characterized function is its ability to catalyze the synthesis of cyclic ADP-ribose (cADPR) from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b2901fe29462d327c579f48eec91160
https://doi.org/10.1182/blood.v104.11.4142.4142

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