Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Sophie A. Millar"'
Autor:
Sophie A. Millar, Stephen G. John, Christopher W. McIntyre, Vera Ralevic, Susan I. Anderson, Saoirse E. O'Sullivan
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Osteocalcin (OCN) is a bone-derived protein that is detected within human calcified vascular tissue. Calcification is particularly prevalent in chronic kidney disease (CKD) patients but the role of OCN in calcification, whether active or passive, has
Externí odkaz:
https://doaj.org/article/1ab0a2ed279943f686423a5b61e5da5b
Publikováno v:
PeerJ, Vol 7, p e7139 (2019)
Bone-derived factors that demonstrate extra-skeletal functions, also termed osteokines, are fast becoming a highly interesting and focused area of cross-disciplinary endocrine research. Osteocalcin (OCN), fibroblast growth factor-23 (FGF23) and lipoc
Externí odkaz:
https://doaj.org/article/03f0d941af2b4bb983e8d4527e448d54
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Background: Cannabidiol is being pursued as a therapeutic treatment for multiple conditions, usually by oral delivery. Animal studies suggest oral bioavailability is low, but literature in humans is not sufficient. The aim of this review was to colla
Externí odkaz:
https://doaj.org/article/f29394b0b4e94723b66fa1cdad6d10f8
Autor:
Nicole L. Stone, Sophie A. Millar, Philip J. J. Herrod, David A. Barrett, Catharine A. Ortori, Valerie A. Mellon, Saoirse E. O’Sullivan
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 12 (2018)
The euphoric feeling described after running is, at least in part, due to increased circulating endocannabinoids (eCBs). eCBs are lipid signaling molecules involved in reward, appetite, mood, memory and neuroprotection. The aim of this study was to i
Externí odkaz:
https://doaj.org/article/965aad594dec4f6fbe79b4f533d9df4b
Publikováno v:
Frontiers in Endocrinology, Vol 8 (2017)
BackgroundOsteocalcin (OC) is an intriguing hormone, concomitantly being the most abundant non-collagenous peptide found in the mineralized matrix of bone, and expanding the endocrine function of the skeleton with far-reaching extra-osseous effects.
Externí odkaz:
https://doaj.org/article/08a699d02dd84154a180b035ab331b9b
A Systematic Review and Meta-Analysis of the In Vivo Haemodynamic Effects of Δ9-Tetrahydrocannabinol
Publikováno v:
Pharmaceuticals, Vol 11, Iss 1, p 13 (2018)
∆9-Tetrahydrocannabinol (THC) has complex effects on the cardiovascular system. We aimed to systematically review studies of THC and haemodynamic alterations. PubMed, Medline, and EMBASE were searched for relevant studies. Changes in blood pressure
Externí odkaz:
https://doaj.org/article/90a658581a85486e90fbf088234c4896
Autor:
Saoirse E. O'Sullivan, Cassandra Smith, Anthony Zulli, Sophie A. Millar, Alan Hayes, Susan I. Anderson, Alexander Tacey, Itamar Levinger, Tawar Qaradakhi
Publikováno v:
Journal of Cellular Physiology
Undercarboxylated osteocalcin (ucOC) improves glucose metabolism; however, its effects on endothelial cell function are unclear. We examined the biological effect of ucOC on endothelial function in animal models ex vivo and human cells in vitro. Isom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e27e10287eb645c2aa86459a599a0b8
https://doi.org/10.1002/jcp.30048
https://doi.org/10.1002/jcp.30048
Publikováno v:
Diabetes Therapy
Introduction While the beneficial effects of sodium-glucose cotransporter-2 (SGLT-2) inhibitors on cardiovascular and renal outcomes are recognized, their direct effects on endothelial function remain unclear. We, therefore, undertook a systematic re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eaa1b841df27ce1da6a34169a69b840
https://doi.org/10.1007/s13300-020-00885-z
https://doi.org/10.1007/s13300-020-00885-z
Autor:
Timothy J. England, Z.D. Bellman, Sophie A. Millar, Andrew Stephen Yates, Nicole L. Stone, Saoirse E. O'Sullivan
Publikováno v:
British Journal of Clinical Pharmacology
Aims Cannabidiol (CBD) is a cannabis‐derived medicinal product with potential application in a wide‐variety of contexts; however, its effective dose in different disease states remains unclear. This review aimed to investigate what doses have bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3bc7befe57d56f2da6d33272b809ca2
https://doi.org/10.1111/bcp.14038
https://doi.org/10.1111/bcp.14038
Publikováno v:
Pharmaceuticals
Pharmaceuticals, Vol 13, Iss 219, p 219 (2020)
Pharmaceuticals, Vol 13, Iss 219, p 219 (2020)
Cannabidiol (CBD) has substantial therapeutic potential, but its development as an effective drug by the pharmaceutical industry is hindered by intrinsic characteristics such as low bioavailability, low water solubility, and variable pharmacokinetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f372be15349da6856233ff91f90e32ae
https://pubmed.ncbi.nlm.nih.gov/32872355
https://pubmed.ncbi.nlm.nih.gov/32872355