Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Sophie A Valkenburg"'
Publikováno v:
Clinical & Translational Immunology, Vol 10, Iss 6, Pp n/a-n/a (2021)
Abstract Objectives Current inactivated influenza vaccines provide suboptimal protection against antigenic drift, and repeated annual vaccinations shape antibody specificity but the effect on protection from infection is not well understood. Methods
Externí odkaz:
https://doaj.org/article/d46cb13abfd64259a8f9d4192437a9da
Autor:
Niloufar Kavian, Asmaa Hachim, Athena PY Li, Carolyn A Cohen, Alex WH Chin, Leo LM Poon, Vicky J Fang, Nancy HL Leung, Benjamin J Cowling, Sophie A Valkenburg
Publikováno v:
Clinical & Translational Immunology, Vol 9, Iss 2, Pp n/a-n/a (2020)
Abstract Objectives Enhanced inactivated influenza vaccines (eIIV) aim to increase immunogenicity and protection compared with the widely used standard IIV (S‐IIV). Methods We tested four vaccines in parallel, FluZone high dose, FluBlok and FluAd v
Externí odkaz:
https://doaj.org/article/cd1adf06bc73447db44b2c422cfff16f
Autor:
Sophie A Valkenburg, Vicky J Fang, Nancy HL Leung, Daniel KW Chu, Dennis KM Ip, Ranawaka APM Perera, Yizhuo Wang, Athena PY Li, JS Malik Peiris, Benjamin J Cowling, Leo LM Poon
Publikováno v:
Clinical & Translational Immunology, Vol 8, Iss 11, Pp n/a-n/a (2019)
Abstract Objectives Influenza causes a spectrum of disease from asymptomatic infection to fatal outcome, and pre‐existing immunity can alter susceptibility and disease severity. In a household transmission study, we recruited outpatients with confi
Externí odkaz:
https://doaj.org/article/aba3a9ea90e644c3946dd75cf36f07d4
Autor:
Carolyn A. Cohen, Nancy H. L. Leung, Prathanporn Kaewpreedee, Kelly W. K. Lee, Janice Zhirong Jia, Alan W. L. Cheung, Samuel M. S. Cheng, Masashi Mori, Dennis K. M. Ip, Leo L. M. Poon, J. S. Malik Peiris, Benjamin J. Cowling, Sophie A. Valkenburg
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Whole virion inactivated vaccine CoronaVac (C) and Spike (S) mRNA BNT162b2 (B) vaccines differ greatly in their ability to elicit neutralizing antibodies but have somewhat comparable effectiveness in protecting from severe COVID-19. We condu
Externí odkaz:
https://doaj.org/article/43c352f9d77447a8b416c96995ea3831
Autor:
Janice Z. Jia, Carolyn A. Cohen, Haogao Gu, Milla R. McLean, Raghavan Varadarajan, Nisha Bhandari, Malik Peiris, Gabriel M. Leung, Leo L. M. Poon, Tim Tsang, Amy W. Chung, Benjamin J. Cowling, Nancy H. L. Leung, Sophie A. Valkenburg
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Cross-reactive antibodies with Fc receptor (FcR) effector functions may mitigate pandemic virus impact in the absence of neutralizing antibodies. In this exploratory study, we use serum from a randomized placebo-controlled trial of seasonal
Externí odkaz:
https://doaj.org/article/c15b260c86f84dffa03009a6bb0b59de
Autor:
Janice Z. Jia, Carolyn A. Cohen, Haogao Gu, Milla R. McLean, Raghavan Varadarajan, Nisha Bhandari, Malik Peiris, Gabriel M. Leung, Leo L. M. Poon, Tim Tsang, Amy W. Chung, Benjamin J. Cowling, Nancy H. L. Leung, Sophie A. Valkenburg
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/dbcc812df33143d0a5c9724faf5629b8
Autor:
Sophie A Valkenburg, Vanessa Venturi, Thurston H Y Dang, Nicola L Bird, Peter C Doherty, Stephen J Turner, Miles P Davenport, Katherine Kedzierska
Publikováno v:
PLoS Pathogens, Vol 8, Iss 2, p e1002544 (2012)
The elderly are particularly susceptible to influenza A virus infections, with increased occurrence, disease severity and reduced vaccine efficacy attributed to declining immunity. Experimentally, the age-dependent decline in influenza-specific CD8(+
Externí odkaz:
https://doaj.org/article/6fa5a2ce4ae94b5194f76687d579ccd1
Autor:
Katherine Kedzierska, Joan M Curtis, Sophie A Valkenburg, Lauren A Hatton, Hiu Kiu, Peter C Doherty, Lukasz Kedzierski
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33161 (2012)
The available evidence suggests that protective immunity to Leishmania is achieved by priming the CD4(+) Th1 response. Therefore, we utilised a reverse genetics strategy to generate influenza A viruses to deliver an immunogenic Leishmania peptide. Th
Externí odkaz:
https://doaj.org/article/3cfebba333e14627a153dcdcbf8fc867
Autor:
Sophie A Valkenburg, Stephanie Gras, Carole Guillonneau, Nicole L La Gruta, Paul G Thomas, Anthony W Purcell, Jamie Rossjohn, Peter C Doherty, Stephen J Turner, Katherine Kedzierska
Publikováno v:
PLoS Pathogens, Vol 6, Iss 8, p e1001039 (2010)
Emergence of a new influenza strain leads to a rapid global spread of the virus due to minimal antibody immunity. Pre-existing CD8(+) T-cell immunity directed towards conserved internal viral regions can greatly ameliorate the disease. However, mutat
Externí odkaz:
https://doaj.org/article/7fe5fc283dff490dac8634d0cb6d116a
Autor:
Jennifer Cable, Siddharth Balachandran, Lisa P. Daley‐Bauer, Arjun Rustagi, Ferrin Antony, Justin J. Frere, Jamie Strampe, Katherine Kedzierska, Judy L. Cannon, Maureen A. McGargill, Daniela Weiskopf, Robert C. Mettelman, Julia Niessl, Paul G. Thomas, Bryan Briney, Sophie A. Valkenburg, Jesse D. Bloom, Pamela J. Bjorkman, Sho Iketani, C. Garrett Rappazzo, Chelsea M. Crooks, Kali F. Crofts, Stefan Pöhlmann, Florian Krammer, Andrea J. Sant, Gary J. Nabel, Stacey Schultz‐Cherry
Publikováno v:
Annals of the New York Academy of Sciences. 1521:32-45
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17ae512b46e8bbda4f04547ea661655b
https://doi.org/10.1111/nyas.14960
https://doi.org/10.1111/nyas.14960