Dynamic microfluidic single-cell screening identifies pheno-tuning compounds to potentiate tuberculosis therapy

Autor: Maxime Mistretta, Mena Cimino, Pascal Campagne, Stevenn Volant, Etienne Kornobis, Olivier Hebert, Christophe Rochais, Patrick Dallemagne, Cédric Lecoutey, Camille Tisnerat, Alban Lepailleur, Yann Ayotte, Steven R. LaPlante, Nicolas Gangneux, Monika Záhorszká, Jana Korduláková, Sophie Vichier-Guerre, Frédéric Bonhomme, Laura Pokorny, Marvin Albert, Jean-Yves Tinevez, Giulia Manina

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)

Abstract Drug-recalcitrant infections are a leading global-health concern. Bacterial cells benefit from phenotypic variation, which can suggest effective antimicrobial strategies. However, probing phenotypic variation entails spatiotemporal analysis

Externí odkaz: https://doaj.org/article/fa9c75f3b4af4a52a3bae94cff9e5192

Dynamic microfluidic single-cell screening identifies pheno-tuning compounds to potentiate tuberculosis therapy

Autor: Maxime Mistretta, Mena Cimino, Pascal Campagne, Stevenn Volant, Etienne Kornobis, Olivier Hebert, Christophe Rochais, Patrick Dallemagne, Cédric Lecoutey, Camille Tisnerat, Alban Lepailleur, Yann Ayotte, Steven R. LaPlante, Nicolas Gangneux, Monika Záhorszká, Jana Korduláková, Sophie Vichier-Guerre, Frédéric Bonhomme, Laura Pokorny, Marvin Albert, Jean-Yves Tinevez, Giulia Manina

Drug-recalcitrant infections are a leading global-health concern. Bacterial cells benefit from phenotypic variation, which can suggest effective anti-microbial strategies. However, probing phenotypic variation entails spatiotemporal analysis of indiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::341d224a1ebe6ec3997b591329728341
https://doi.org/10.1101/2023.03.31.535085

Author response for 'Interaction network among de novo purine nucleotide biosynthesis enzymes in Escherichia coli'

Autor: null Antoine Gedeon, null Gouzel Karimova, null Nour Ayoub, null Julien Dairou, null Quentin Giai Gianetto, null Sophie Vichier‐Guerre, null Pierre‐Olivier Vidalain, null Daniel Ladant, null Hélène Munier‐Lehmann

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::956b68f9b7f19494ef3ad8c61219e0c8
https://doi.org/10.1111/febs.16746/v2/response1

Crystal structure of the Trypanosoma cruzi EIF4E5 translation factor homologue in complex with mRNA cap-4

Autor: Bruno Moisés de Matos, Sophie Vichier-Guerre, Tatiana Reichert da Silva Assunção, Laurence Dugué, Nilson Ivo Tonin Zanchin, Beatriz G. Guimarães, Sylvie Pochet, Lidia Watanabe Reolon

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, 2019, ⟨10.1093/nar/gkz339⟩
Nucleic Acids Research, Oxford University Press, 2019, ⟨10.1093/nar/gkz339⟩

International audience; Association of the initiation factor eIF4E with the mRNA cap structure is a key step for translation. Trypanosomatids present six eIF4E homologues, showing a low conservation and also differing significantly from the IF4Es of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2511672a1d44077cc5a88eb9566b508e
https://doi.org/10.1093/nar/gkz339

An expedient synthesis of flexible nucleosides via a regiocontrolled enzymatic glycosylation of functionalized imidazoles

Autor: Laurence Dugué, Sylvie Pochet, Frédéric J. Bonhomme, Sophie Vichier-Guerre

Publikováno v: Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2017, 15 (38), pp.8193-8203. ⟨10.1039/C7OB01850A⟩
Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry, 2017, 15 (38), pp.8193-8203. ⟨10.1039/C7OB01850A⟩

International audience; A versatile two-step synthesis of C4- and C5-arylated 2′-deoxyribosylimidazoles was elaborated using enzymatic N-transglycosylation followed by microwave-assisted Pd-catalysed arylation reactions. We report herein the reacti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81f008b7e6858c8b94797034d7a67779
https://doi.org/10.1039/c7ob01850a