Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Sophie, Van Linthout"'
Autor:
Kathleen Pappritz, Sarah-Lena Puhl, Isabel Matz, Erik Brauer, Yi Xuan Shia, Muhammad El-Shafeey, Suzanne E. Koch, Kapka Miteva, Christin Mucha, Georg N. Duda, Ansgar Petersen, Sabine Steffens, Carsten Tschöpe, Sophie Van Linthout
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
BackgroundAge and sex are prominent risk factors for heart failure and determinants of structural and functional changes of the heart. Cardiac fibroblasts (cFB) are beyond their task as extracellular matrix-producing cells further recognized as infla
Externí odkaz:
https://doaj.org/article/431c58d3a3d04068a86c2900a66337bc
Autor:
Kathleen Pappritz, Jie Lin, Muhammad El‐Shafeey, Henry Fechner, Uwe Kühl, Alessio Alogna, Frank Spillmann, Ahmed Elsanhoury, Rainer Schulz, Carsten Tschöpe, Sophie Van Linthout
Publikováno v:
ESC Heart Failure, Vol 9, Iss 2, Pp 925-941 (2022)
Abstract Aim The acute phase of a coxsackievirus 3 (CVB3)‐induced myocarditis involves direct toxic cardiac effects and the systemic activation of the immune system, including the cardiosplenic axis. Consequently, the nucleotide‐binding oligomeri
Externí odkaz:
https://doaj.org/article/a2758d127c774136b0ea4616cf588917
Autor:
Danielle J. Beetler, Katelyn A. Bruno, Damian N. Di Florio, Erika J. Douglass, Swikriti Shrestha, Carsten Tschöpe, Madeleine W. Cunningham, Jan Krejčí, Julie Bienertová-Vašků, Sabine Pankuweit, Dennis M. McNamara, Eun-Seok Jeon, Sophie van Linthout, Lori A. Blauwet, Leslie T. Cooper, DeLisa Fairweather
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2023)
AimsThe goal of this study was to determine whether sex and age differences exist for soluble ST2 (sST2) for several cardiovascular diseases (CVDs).MethodsWe examined sST2 levels using an ELISA kit for myocarditis (n = 303), cardiomyopathy (n = 293),
Externí odkaz:
https://doaj.org/article/9a56d2d871404713929824059dc4a863
Autor:
Sophie Van Linthout, Hans-Dieter Volk
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Inflammation and a dysregulated immune system are common denominators of cancer and cardiovascular disease (CVD). Immuno-cardio-oncology addresses the interconnected immunological aspect in both cancer and CVD and the integration of immunotherapies a
Externí odkaz:
https://doaj.org/article/d4b65d8d276442dbadc4e5e97fb3cc5e
Autor:
Margo Daems, Laurens Liesenborghs, Robbert Boudewijns, Steven J. Simmonds, Sirima Kraisin, Jore Van Wauwe, Ilona Cuijpers, Jana Raman, Nadèche Geuens, Tina Van Buyten, Marleen Lox, Peter Verhamme, Sophie Van Linthout, Kimberly Martinod, Stephane Heymans, Carsten Tschöpe, Johan Neyts, Elizabeth A. V. Jones
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Recovered COVID-19 patients often display cardiac dysfunction, even after a mild infection. Most current histological results come from patients that are hospitalized and therefore represent more severe outcomes than most COVID-19 patients face. To o
Externí odkaz:
https://doaj.org/article/ee7cb0ca8bc346af8a2a1e3630d009d1
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Interleukin-6 (IL-6) is an important player in chronic inflammation associated with heart failure and tumor-induced cachexia. Fibroblasts are salient mediators of both inflammation and fibrosis. Whereas the general outcome of IL-6 on the heart’s fu
Externí odkaz:
https://doaj.org/article/0da0741da2a3469691c955b2ff100ab5
Autor:
Carsten Tschöpe, Sophie Van Linthout, Sebastian Jäger, Robert Arndt, Tobias Trippel, Irene Müller, Ahmed Elsanhoury, Susanne Rutschow, Stefan D. Anker, Heinz‐Peter Schultheiss, Matthias Pauschinger, Frank Spillmann, Kathleen Pappritz
Publikováno v:
ESC Heart Failure, Vol 7, Iss 5, Pp 2838-2852 (2020)
Abstract Aims Left ventricular (LV) dysfunction in viral myocarditis is attributed to myocardial inflammation and fibrosis, inducing acute and long‐time cardiac damage. Interventions are not established. On the basis of the link between inflammatio
Externí odkaz:
https://doaj.org/article/5b4026b304bf43fc927b76c3a2d15825
Autor:
Christiane Ott, Kathleen Pappritz, Niklas Hegemann, Cathleen John, Sarah Jeuthe, Cameron S. McAlpine, Yoshiko Iwamoto, Jonathan H. Lauryn, Jan Klages, Robert Klopfleisch, Sophie Van Linthout, Fil Swirski, Matthias Nahrendorf, Ulrich Kintscher, Tilman Grune, Wolfgang M. Kuebler, Jana Grune
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 23 (2021)
Background Degenerative aortic valve (AoV) disease and resulting aortic stenosis are major clinical health problems. Murine models of valve disease are rare, resulting in a translational knowledge gap on underlying mechanisms, functional consequences
Externí odkaz:
https://doaj.org/article/4f8163deacc849779f7e6d02eabd3389
Autor:
Radu Tanacli, Patrick Doeblin, Collin Götze, Victoria Zieschang, Alessandro Faragli, Christian Stehning, Grigorios Korosoglou, Jennifer Erley, Jakob Weiss, Alexander Berger, Felix Pröpper, Fridolin Steinbeis, Titus Kühne, Franziska Seidel, Dominik Geisel, Thula Cannon Walter-Rittel, Philipp Stawowy, Martin Witzenrath, Karin Klingel, Sophie Van Linthout, Burkert Pieske, Carsten Tschöpe, Sebastian Kelle
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Background: Despite the ongoing global pandemic, the impact of COVID-19 on cardiac structure and function is still not completely understood. Myocarditis is a rare but potentially serious complication of other viral infections with variable recovery,
Externí odkaz:
https://doaj.org/article/b3f5360e0e7f4665aeb9f9f0ebd50958
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome with diverse etiologies and pathophysiological factors. Obesity and type 2 diabetes mellitus (T2DM), conditions that coexist frequently, induce a cluster of metabolic
Externí odkaz:
https://doaj.org/article/ce6b2bba632c42a9851fea98d74ceddb