Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Sophie, Trefely"'
Autor:
Mary T. Doan, Michael D. Neinast, Erika L. Varner, Kenneth C. Bedi, Jr., David Bartee, Helen Jiang, Sophie Trefely, Peining Xu, Jay P. Singh, Cholsoon Jang, J. Eduardo Rame, Donita C. Brady, Jordan L. Meier, Kenneth B. Marguiles, Zoltan Arany, Nathaniel W. Snyder
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 6, Pp 100224- (2022)
Anabolic metabolism of carbon in mammals is mediated via the one- and two-carbon carriers S-adenosyl methionine and acetyl-coenzyme A. In contrast, anabolic metabolism of three-carbon units via propionate has not been shown to extensively occur. Mamm
Externí odkaz:
https://doaj.org/article/37582cdc3e554e4a95aee9b775a2c9c9
Autor:
Sydney Campbell, Clementina Mesaros, Luke Izzo, Hayley Affronti, Michael Noji, Bethany E Schaffer, Tiffany Tsang, Kathryn Sun, Sophie Trefely, Salisa Kruijning, John Blenis, Ian A Blair, Kathryn E Wellen
Publikováno v:
eLife, Vol 10 (2021)
Tumors frequently exhibit aberrant glycosylation, which can impact cancer progression and therapeutic responses. The hexosamine biosynthesis pathway (HBP) produces uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), a major substrate for glycosylat
Externí odkaz:
https://doaj.org/article/5ce0bca35ac845fba57a2e6f6f790030
Autor:
Sophie Trefely, Joyce Liu, Katharina Huber, Mary T. Doan, Helen Jiang, Jay Singh, Eliana von Krusenstiern, Anna Bostwick, Peining Xu, Juliane G. Bogner-Strauss, Kathryn E. Wellen, Nathaniel W. Snyder
Publikováno v:
Molecular Metabolism, Vol 30, Iss , Pp 61-71 (2019)
Objective: The dynamic regulation of metabolic pathways can be monitored by stable isotope tracing. Yet, many metabolites are part of distinct processes within different subcellular compartments. Standard isotope tracing experiments relying on analys
Externí odkaz:
https://doaj.org/article/3125540e52be4f41a634e1f00b23f7b5
Autor:
Erika L. Varner, Sophie Trefely, David Bartee, Eliana von Krusenstiern, Luke Izzo, Carmen Bekeova, Roddy S. O'Connor, Erin L. Seifert, Kathryn E. Wellen, Jordan L. Meier, Nathaniel W. Snyder
Publikováno v:
Open Biology, Vol 10, Iss 9 (2020)
Lysine lactoylation is a recently described protein post-translational modification (PTM). However, the biochemical pathways responsible for this acylation remain unclear. Two metabolite-dependent mechanisms have been proposed: enzymatic histone lysi
Externí odkaz:
https://doaj.org/article/adfcecc3a8e9419db3b33858cefd038c
Publikováno v:
Molecular Metabolism, Vol 38, Iss , Pp 100941- (2020)
Background: Many metabolites serve as important signalling molecules to adjust cellular activities and functions based on nutrient availability. Links between acetyl-CoA metabolism, histone lysine acetylation, and gene expression have been documented
Externí odkaz:
https://doaj.org/article/55eb0fe499d346a29a70e058da3713d4
Autor:
Juan C. Garcia-Canaveras, David Heo, Sophie Trefely, John Leferovich, Chong Xu, Benjamin I. Philipson, Saba Ghassemi, Michael C. Milone, Edmund K. Moon, Nathaniel W. Snyder, Carl H. June, Joshua D. Rabinowitz, Roddy S. O’Connor
Publikováno v:
Cells, Vol 10, Iss 9, p 2334 (2021)
The metabolic milieu of solid tumors provides a barrier to chimeric antigen receptor (CAR) T-cell therapies. Excessive lactate or hypoxia suppresses T-cell growth, through mechanisms including NADH buildup and the depletion of oxidized metabolites. N
Externí odkaz:
https://doaj.org/article/50d53015c0884756be813e46c6a7e1ed
Autor:
Sully Fernandez, John M. Viola, AnnMarie Torres, Martina Wallace, Sophie Trefely, Steven Zhao, Hayley C. Affronti, Jivani M. Gengatharan, David A. Guertin, Nathaniel W. Snyder, Christian M. Metallo, Kathryn E. Wellen
Publikováno v:
Cell Reports, Vol 27, Iss 9, Pp 2772-2784.e6 (2019)
Summary: Sugars and refined carbohydrates are major components of the modern diet. ATP-citrate lyase (ACLY) is upregulated in adipocytes in response to carbohydrate consumption and generates acetyl-coenzyme A (CoA) for both lipid synthesis and acetyl
Externí odkaz:
https://doaj.org/article/b1e97b77b6bb47a5b16ec6174ac70f5c
Autor:
Luke T. Izzo, Sophie Trefely, Christina Demetriadou, Jack M. Drummond, Takuya Mizukami, Nina Kuprasertkul, Aimee T. Farria, Phuong T. T. Nguyen, Nivitha Murali, Lauren Reich, Daniel S. Kantner, Joshua Shaffer, Hayley Affronti, Alessandro Carrer, Andrew Andrews, Brian C. Capell, Nathaniel W. Snyder, Kathryn E. Wellen
Publikováno v:
Science Advances. 9
The metabolite acetyl-CoA is necessary for both lipid synthesis in the cytosol and histone acetylation in the nucleus. The two canonical precursors to acetyl-CoA in the nuclear-cytoplasmic compartment are citrate and acetate, which are processed to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7356994fc12704f2e3379bbefe59fadb
https://doi.org/10.1126/sciadv.adf0115
https://doi.org/10.1126/sciadv.adf0115
Autor:
Kathryn E. Wellen, Ben Z. Stanger, Nathaniel W. Snyder, Benjamin A. Garcia, Alessandro Gardini, Marco Trizzino, Yogev Sela, Shaun Egolf, Sharanya Sivanand, Hayley C. Affronti, Joshua L.D. Parris, Simone Sidoli, Kollin C. Schultz, Robert J. Norgard, Sydney L. Campbell, Steven Zhao, Sophie Trefely, Alessandro Carrer
Figures S1-S7 and Table S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::224b8fe602dcdfae5be3cb3ac813063a
https://doi.org/10.1158/2159-8290.22532489.v1
https://doi.org/10.1158/2159-8290.22532489.v1
Autor:
Steven Zhao, AnnMarie Torres, Ryan A. Henry, Sophie Trefely, Martina Wallace, Joyce V. Lee, Alessandro Carrer, Arjun Sengupta, Sydney L. Campbell, Yin-Ming Kuo, Alexander J. Frey, Noah Meurs, John M. Viola, Ian A. Blair, Aalim M. Weljie, Christian M. Metallo, Nathaniel W. Snyder, Andrew J. Andrews, Kathryn E. Wellen
Publikováno v:
Cell Reports, Vol 17, Iss 4, Pp 1037-1052 (2016)
Mechanisms of metabolic flexibility enable cells to survive under stressful conditions and can thwart therapeutic responses. Acetyl-coenzyme A (CoA) plays central roles in energy production, lipid metabolism, and epigenomic modifications. Here, we sh
Externí odkaz:
https://doaj.org/article/1368c98dfbae4b1085e1112de5ae4ed8