Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Sophie, Stukas"'
Autor:
Melina Messing, Mypinder S. Sekhon, Michael R. Hughes, Sophie Stukas, Ryan L. Hoiland, Jennifer Cooper, Nyra Ahmed, Mark S. Hamer, Yicong Li, Samuel B. Shin, Lin Wei Tung, Cheryl L. Wellington, Don D. Sin, Kevin B. Leslie, Kelly M. McNagny
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The COVID-19 pandemic continues to challenge the capacities of hospital ICUs which currently lack the ability to identify prospectively those patients who may require extended management. In this study of 90 ICU COVID-19 patients, we evaluated serum
Externí odkaz:
https://doaj.org/article/e664c34af33143408e6843b6957ebf8c
Autor:
Sophie Stukas, George Goshua, Angus Kinkade, Rebecca Grey, Gregory Mah, Catherine M. Biggs, Shahin Jamal, Sonny Thiara, Tim T.Y. Lau, Jolanta Piszczek, Nilu Partovi, David D Sweet, Agnes Y.Y. Lee, Cheryl L. Wellington, Mypinder S. Sekhon, Luke Y.C. Chen
Publikováno v:
The Lancet Regional Health. Americas, Vol 11, Iss , Pp 100228- (2022)
Summary: Background: Interleukin-6 inhibitors reduce mortality in severe COVID-19. British Columbia began using tocilizumab 8 mg/kg (maximum 800 mg) in January 2021 in critically ill patients with COVID-19, but due to drug shortages, decreased dosing
Externí odkaz:
https://doaj.org/article/5fe720dec2324ee885ff324e824e3cb4
Autor:
Emily B. Button, Wai Hang Cheng, Carlos Barron, Honor Cheung, Asma Bashir, Jennifer Cooper, Jasmine Gill, Sophie Stukas, David C. Baron, Jerome Robert, Elyn M. Rowe, Peter A. Cripton, Cheryl L. Wellington
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-27 (2021)
Abstract Background Glial fibrillary acidic protein (GFAP) has emerged as a promising fluid biomarker for several neurological indications including traumatic brain injury (TBI), a leading cause of death and disability worldwide. In humans, serum or
Externí odkaz:
https://doaj.org/article/f34d341eb55745efa6c3823f103e6a93
Autor:
Jerome Robert, Nicholas L. Weilinger, Li-Ping Cao, Stefano Cataldi, Emily B. Button, Sophie Stukas, Emma M. Martin, Philip Seibler, Megan Gilmour, Tara M. Caffrey, Elyn M. Rowe, Jianjia Fan, Brian MacVicar, Matthew J. Farrer, Cheryl L. Wellington
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-18 (2020)
Abstract Introduction The neurovascular unit (NVU) – the interaction between the neurons and the cerebrovasculature – is increasingly important to interrogate through human-based experimental models. Although advanced models of cerebral capillari
Externí odkaz:
https://doaj.org/article/bf6b04e51e7642eaa8ed05bcd04de018
Autor:
Emily B. Button, Guilaine K. Boyce, Anna Wilkinson, Sophie Stukas, Arooj Hayat, Jianjia Fan, Brennan J. Wadsworth, Jerome Robert, Kris M. Martens, Cheryl L. Wellington
Publikováno v:
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-18 (2019)
Abstract Background Alzheimer’s disease (AD) is defined by amyloid beta (Aβ) plaques and neurofibrillary tangles and characterized by neurodegeneration and memory loss. The majority of AD patients also have Aβ deposition in cerebral vessels known
Externí odkaz:
https://doaj.org/article/fb2a691f58d94abb8998aa69e3f67f4a
Autor:
Wai Hang Cheng, Kris M. Martens, Asma Bashir, Honor Cheung, Sophie Stukas, Ebrima Gibbs, Dhananjay R. Namjoshi, Emily B. Button, Anna Wilkinson, Carlos J. Barron, Neil R. Cashman, Peter A. Cripton, Cheryl L. Wellington
Publikováno v:
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-21 (2019)
Abstract Background The annual incidence of traumatic brain injury (TBI) in the United States is over 2.5 million, with approximately 3–5 million people living with chronic sequelae. Compared with moderate-severe TBI, the long-term effects of mild
Externí odkaz:
https://doaj.org/article/52e1bef695e242df8ce41ed0e694e86f
Autor:
Luke Y.C. Chen, Catherine M. Biggs, Shahin Jamal, Sophie Stukas, Cheryl L. Wellington, Mypinder S. Sekhon
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 5, Pp 100269- (2021)
Summary: Data suggest that interleukin (IL)-6 blockade could reduce mortality in severe COVID-19, yet IL-6 is only modestly elevated in most patients. Chen et al. describe the role of soluble interleukin-6 receptor (sIL-6R) in IL-6 trans-signaling an
Externí odkaz:
https://doaj.org/article/a24a15f5b1734782bc15e9145aadade4
Autor:
Alexander Leatherdale, Sophie Stukas, Victor Lei, Henry E. West, Christopher J. Campbell, Ryan L. Hoiland, Jennifer Cooper, Cheryl L. Wellington, Mypinder S. Sekhon, Edward L. G. Pryzdial, Edward M. Conway
Publikováno v:
Medical Microbiology and Immunology
Mechanisms underlying the SARS-CoV-2-triggered hyperacute thrombo-inflammatory response that causes multi-organ damage in coronavirus disease 2019 (COVID-19) are poorly understood. Several lines of evidence implicate overactivation of complement. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6283286b89ac58f9e3d407d54ecf4910
http://europepmc.org/articles/PMC8761108
http://europepmc.org/articles/PMC8761108
Autor:
Sophie Stukas, Jennifer Cooper, David K. Menon, Donald E. G. Griesdale, Mypinder S. Sekhon, Cheryl L. Wellington, Veronica Hirsch-Reinshagen, Sonny Thiara, Nicholas A Fergusson, Philip N. Ainslie, Denise Foster, Edward M. Conway, Peter Gooderham, Ryan L. Hoiland
Publikováno v:
Circulation Research
Supplemental Digital Content is available in the text.
Rationale: Secondary brain hypoxia portends significant mortality in ischemic brain diseases; yet, our understanding of hypoxic ischemic brain injury (HIBI) pathophysiology in humans remains
Rationale: Secondary brain hypoxia portends significant mortality in ischemic brain diseases; yet, our understanding of hypoxic ischemic brain injury (HIBI) pathophysiology in humans remains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c20e90dd2ecb5b6d10d5da6d6d9e9fd7
http://europepmc.org/articles/PMC8376277
http://europepmc.org/articles/PMC8376277