Dual-Hit: Glyphosate exposure at NOAEL level negatively impacts birth and glia-behavioural measures in heterozygous shank3 mutants

Autor: Sophie Sakkaki, Noemie Cresto, Raphaël Chancel, Maé Jaulmes, Emma Zub, Marine Blaquière, Pierre Sicard, Tangui Maurice, Sandrine Ellero-Simatos, Laurence Gamet-Payrastre, Nicola Marchi, Julie Perroy

Publikováno v: Environment International, Vol 180, Iss , Pp 108201- (2023)

The omnipresence of environmental contaminants represents a health danger with ramifications for adverse neurological trajectories. Here, we tested the dual-hit hypothesis that continuous exposure to non-observable adverse effect level (NOAEL) glypho

Externí odkaz: https://doaj.org/article/ec621fdd13bc4c01a42a4701c968b3eb

The mGlu7 receptor provides protective effects against epileptogenesis and epileptic seizures

Autor: Benoit Girard, Pola Tuduri, Maria Paula Moreno, Sophie Sakkaki, Cedric Barboux, Tristan Bouschet, Annie Varrault, Jihane Vitre, Isabelle McCort-Tranchepain, Julien Dairou, Francine Acher, Laurent Fagni, Nicola Marchi, Julie Perroy, Federica Bertaso

Publikováno v: Neurobiology of Disease, Vol 129, Iss , Pp 13-28 (2019)

Finding new targets to control or reduce seizure activity is essential to improve the management of epileptic patients. We hypothesized that activation of the pre-synaptic and inhibitory metabotropic glutamate receptor type 7 (mGlu7) reduces spontane

Externí odkaz: https://doaj.org/article/989e0dcdf7ed41f0ab1a3772c10dfdc1

The Shank3

Autor: Nathalie, Bouquier, Sophie, Sakkaki, Fabrice, Raynaud, Anne-Laure, Hemonnot-Girard, Vincent, Seube, Vincent, Compan, Federica, Bertaso, Julie, Perroy, Enora, Moutin

Publikováno v: Frontiers in neuroscience. 16

Shank3 is a scaffolding protein essential for the organization and function of the glutamatergic postsynapse. Monogenic mutations inIn this study, we created a novel transgenic mouse line, the Shank3We show that the endogenous Venus-Shank3a protein i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0980de50c11e75fb5e13763569c8102e
https://pubmed.ncbi.nlm.nih.gov/36570823

Focal Dorsal Hippocampal Nav1.1 Knock Down Alters Place Cell Temporal Coordination and Spatial Behavior

Autor: Sophie Sakkaki, Sylvain J. Barriere, Pierre-Pascal Lenck-Santini, Rod C. Scott, Alex C. Bender

Publikováno v: Cerebral Cortex
Cerebral Cortex, Oxford University Press (OUP), 2020, 30, pp.5049-5066. ⟨10.1093/cercor/bhaa101⟩
Cerebral Cortex, 2020, 30, pp.5049-5066. ⟨10.1093/cercor/bhaa101⟩
Cerebral Cortex (New York, NY)
Cerebral Cortex, Oxford University Press (OUP), 2020, ⟨10.1093/cercor/bhaa101⟩

Alterations in the voltage-gated sodium channel Nav.1.1 are implicated in various neurological disorders, including epilepsy, Alzheimer’s disease, and autism spectrum disorders. Previous studies suggest that the reduction of Nav1.1 expression leads

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::150a3bff9ef44e6e19653f9c66c28216
https://hal.archives-ouvertes.fr/hal-02863810

Temporal Coordination of Hippocampal Neurons Reflects Cognitive Outcome Post-febrile Status Epilepticus

Autor: Katelin P. Patterson, Rod C. Scott, Tallie Z. Baram, Gregory L. Holmes, Sylvain J. Barriere, Jeremy M. Barry, Pierre-Pascal Lenck-Santini, Sophie Sakkaki

Publikováno v: EBioMedicine
EBioMedicine, Vol 7, Iss C, Pp 175-190 (2016)

The coordination of dynamic neural activity within and between neural networks is believed to underlie normal cognitive processes. Conversely, cognitive deficits that occur following neurological insults may result from network discoordination. We hy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::172e8f713658a403389a0edc2a3e2d2f
https://doi.org/10.1016/j.ebiom.2016.03.039