Zobrazeno 1 - 10
of 211
pro vyhledávání: '"Sophie, Lotersztajn"'
Autor:
Morgane Mabire, Pushpa Hegde, Adel Hammoutene, Jinghong Wan, Charles Caër, Rola Al Sayegh, Mathilde Cadoux, Manon Allaire, Emmanuel Weiss, Tristan Thibault-Sogorb, Olivier Lantz, Michèle Goodhardt, Valérie Paradis, Pierre de la Grange, Hélène Gilgenkrantz, Sophie Lotersztajn
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Liver cirrhosis is characterised by extensive fibrosis of the liver, and understanding the underpinning immunological processes is important in designing intervention. Here authors show that Mucosal-Associated Invariant T cells are instrumental to co
Externí odkaz:
https://doaj.org/article/49d8dca78ad94f9fac7e66da26a40cc1
Autor:
Manon Allaire, Rola Al Sayegh, Morgane Mabire, Adel Hammoutene, Matthieu Siebert, Charles Caër, Mathilde Cadoux, JingHong Wan, Aida Habib, Maude Le Gall, Pierre de la Grange, Hervé Guillou, Catherine Postic, Valérie Paradis, Sophie Lotersztajn, Hélène Gilgenkrantz
Publikováno v:
JHEP Reports, Vol 5, Iss 8, Pp 100794- (2023)
Background & Aims: Liver regeneration is a repair process in which metabolic reprogramming of parenchymal and inflammatory cells plays a major role. Monoacylglycerol lipase (MAGL) is an ubiquitous enzyme at the crossroad between lipid metabolism and
Externí odkaz:
https://doaj.org/article/346571883a5f4eb1b52cd8a45a9591b1
Autor:
Irini Evnouchidou, Pascal Chappert, Samira Benadda, Andres Zucchetti, Mirjana Weimershaus, Marcelle Bens, Vivien Caillens, Despoina Koumantou, Sophie Lotersztajn, Peter van Endert, Jean Davoust, Pierre Guermonprez, Claire Hivroz, David A. Gross, Loredana Saveanu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
T cell receptors (TCR) are internalized when activated by their ligands. Here the authors show that the internalized TCRs are localized to endosomes expressing IRAP and Syntaxin 6 to maintain intracellular signalling capacity, whose importance is sho
Externí odkaz:
https://doaj.org/article/64b251bfea0c4668a8923bf82ed550e8
Autor:
Sophie Lotersztajn, Ariane Mallat
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 1 (2022)
Externí odkaz:
https://doaj.org/article/5776560aa19b4a81b87df2dc8d33f922
Autor:
Matteo Tardelli, Francesca V. Bruschi, Thierry Claudel, Claudia D. Fuchs, Nicole Auer, Victoria Kunczer, Tatjana Stojakovic, Hubert Scharnagl, Aida Habib, Gernot F. Grabner, Robert Zimmermann, Sophie Lotersztajn, Michael Trauner
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 7, Pp 1284-1292 (2019)
Monoacylglycerol lipase (MGL) is the rate-limiting enzyme in the degradation of monoacylglycerols. To examine the role of MGL in hepatic steatosis, WT and MGL KO (MGL−/−) mice were challenged with a Western diet (WD) over 12 weeks. Lipid metaboli
Externí odkaz:
https://doaj.org/article/02a72589b0a44e1baef87dba030ccf71
Autor:
Emmanuel Weiss, Pierre de la Grange, Mylène Defaye, Juan José Lozano, Ferrán Aguilar, Pushpa Hegde, Ariane Jolly, Lucile Moga, Sukriti Sukriti, Banwari Agarwal, Haqeeqat Gurm, Marion Tanguy, Johanne Poisson, Joan Clària, Paer-Selim Abback, Axel Périanin, Gautam Mehta, Rajiv Jalan, Claire Francoz, Pierre-Emmanuel Rautou, Sophie Lotersztajn, Vicente Arroyo, François Durand, Richard Moreau
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Background and AimsPatients with cirrhosis and acute-on-chronic liver failure (ACLF) have immunosuppression, indicated by an increase in circulating immune-deficient monocytes. The aim of this study was to investigate simultaneously the major blood-i
Externí odkaz:
https://doaj.org/article/08bb7077b5d446efbff237f3b2fd3c80
Autor:
Sophie Lotersztajn
Publikováno v:
JHEP Reports, Vol 3, Iss 1, Pp 100225- (2021)
Externí odkaz:
https://doaj.org/article/66c63cecff554d06881f84ba4130c1e6
Autor:
Sophie Lotersztajn
Publikováno v:
JHEP Reports, Vol 2, Iss 1, Pp - (2020)
Externí odkaz:
https://doaj.org/article/36f3e07d5c974df4895baebb0c2772a7
Autor:
Pushpa Hegde, Emmanuel Weiss, Valérie Paradis, Jinghong Wan, Morgane Mabire, Sukriti Sukriti, Pierre-Emmanuel Rautou, Miguel Albuquerque, Olivia Picq, Abhishak Chandra Gupta, Gladys Ferrere, Hélène Gilgenkrantz, Badr Kiaf, Amine Toubal, Lucie Beaudoin, Philippe Lettéron, Richard Moreau, Agnès Lehuen, Sophie Lotersztajn
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Hepatic fibrosis represents the liver response to chronic injury and can lead to cirrhosis. Here the authors show that mucosal-associated invariant T cells mediate chronic inflammation and fibrogenesis in the liver by inducing a proinflammatory pheno
Externí odkaz:
https://doaj.org/article/68dba654aed943aea66393450ba3bbd9
Publikováno v:
Hepatology.