Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Sophie, Lev"'
Autor:
Bethany Grace Bowring, Pooja Sethiya, Desmarini Desmarini, Sophie Lev, Lisa Tran Le, Yong-Sun Bahn, Seung-Heon Lee, Akio Toh-e, Nicholas Proschogo, Tom Savage, Julianne Teresa Djordjevic
Publikováno v:
mBio, Vol 14, Iss 2 (2023)
ABSTRACT Fungal pathogens uniquely regulate phosphate homeostasis via the cyclin-dependent kinase (CDK) signaling machinery of the phosphate acquisition (PHO) pathway (Pho85 kinase-Pho80 cyclin-CDK inhibitor Pho81), providing drug-targeting opportuni
Externí odkaz:
https://doaj.org/article/d5ca8be315354e79bcf60f2bea130499
Autor:
Desmarini Desmarini, Daniel Truong, Lorna Wilkinson-White, Chandrika Desphande, Mario Torrado, Joel P. Mackay, Jacqueline M. Matthews, Tania C. Sorrell, Sophie Lev, Philip E. Thompson, Julianne Teresa Djordjevic
Publikováno v:
Biomolecules, Vol 12, Iss 10, p 1526 (2022)
New antifungals with unique modes of action are urgently needed to treat the increasing global burden of invasive fungal infections. The fungal inositol polyphosphate kinase (IPK) pathway, comprised of IPKs that convert IP3 to IP8, provides a promisi
Externí odkaz:
https://doaj.org/article/fe7ab847de6948a7add6e26a15a3fb16
Autor:
Eamim Daidrê Squizani, Júlia Catarina Vieira Reuwsaat, Sophie Lev, Heryk Motta, Julia Sperotto, Keren Kaufman-Francis, Desmarini Desmarini, Marilene Henning Vainstein, Charley Christian Staats, Julianne T. Djordjevic, Lívia Kmetzsch
Publikováno v:
mSphere, Vol 5, Iss 5 (2020)
ABSTRACT Intracellular calcium (Ca2+) is crucial for signal transduction in Cryptococcus neoformans, the major cause of fatal fungal meningitis. The calcineurin pathway is the only Ca2+-requiring signaling cascade implicated in cryptococcal stress ad
Externí odkaz:
https://doaj.org/article/af512a2c632e48f29809129f84c64afb
Autor:
Desmarini Desmarini, Sophie Lev, David Furkert, Ben Crossett, Adolfo Saiardi, Keren Kaufman-Francis, Cecilia Li, Tania C. Sorrell, Lorna Wilkinson-White, Jacqueline Matthews, Dorothea Fiedler, Julianne Teresa Djordjevic
Publikováno v:
mBio, Vol 11, Iss 5 (2020)
ABSTRACT In the human-pathogenic fungus Cryptococcus neoformans, the inositol polyphosphate signaling pathway is critical for virulence. We recently demonstrated the key role of the inositol pyrophosphate IP7 (isomer 5-PP-IP5) in driving fungal virul
Externí odkaz:
https://doaj.org/article/a8826e64d46d4f19bb5e464319b44f8e
Autor:
Sophie Lev, Cecilia Li, Desmarini Desmarini, Tania C. Sorrell, Adolfo Saiardi, Julianne T. Djordjevic
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)
Invasive fungal pathogens cause more than 300 million serious human infections and 1.6 million deaths per year. A clearer understanding of the mechanisms by which these fungi cause disease is needed to identify novel targets for urgently needed thera
Externí odkaz:
https://doaj.org/article/cf588ad6e1324771ada890c05fa9669c
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Host defenses expose fungal pathogens to oxidants and antimicrobial chemicals. The fungal cell employs conserved eukaryotic signaling pathways and dedicated transcription factors to program its response to these stresses. The oxidant-sensitive transc
Externí odkaz:
https://doaj.org/article/2957c80b1f0a42b2843cd366c63bb98f
Autor:
Sophie Lev, Thusitha Rupasinghe, Desmarini Desmarini, Keren Kaufman-Francis, Tania Christine Sorrell, Ute Roessner, Julianne Teresa Djordjevic
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0212651 (2019)
The phosphate sensing and acquisition (PHO) pathway of Cryptococcus neoformans is essential for growth in phosphate-limiting conditions and for dissemination of infection in a mouse model. Its key transcription factor, Pho4, regulates expression of g
Externí odkaz:
https://doaj.org/article/f4cd5f35ee78456285e6235bb82dd5aa
Autor:
Sophie Lev, Cecilia Li, Desmarini Desmarini, David Liuwantara, Tania C. Sorrell, Wayne J. Hawthorne, Julianne T. Djordjevic
Publikováno v:
Pathogens, Vol 9, Iss 9, p 684 (2020)
Cryptococcus neoformans is a human fungal pathogen that adapts its metabolism to cope with limited oxygen availability, nutrient deprivation and host phagocytes. To gain insight into cryptococcal metabolism, we optimized a protocol for the Seahorse A
Externí odkaz:
https://doaj.org/article/b809c2eb3e044d85a9afd7bb1389ec03
Autor:
Sophie Lev, Julianne Teresa Djordjevic
Publikováno v:
PLoS Pathogens, Vol 14, Iss 6, p e1007021 (2018)
Externí odkaz:
https://doaj.org/article/d6420604a19546b7bf3d38e12e77664b
Autor:
Sophie Lev, Keren Kaufman-Francis, Desmarini Desmarini, Pierre G. Juillard, Cecilia Li, Sebastian A. Stifter, Carl G. Feng, Tania C. Sorrell, Georges E. R. Grau, Yong-Sun Bahn, Julianne T. Djordjevic
Publikováno v:
mSphere, Vol 2, Iss 1 (2017)
ABSTRACT Phosphate acquisition by fungi is regulated by the phosphate-sensing and acquisition (PHO) signaling pathway. Cryptococcus neoformans disseminates from the lung to the brain and is the commonest cause of fungal meningitis worldwide. To inves
Externí odkaz:
https://doaj.org/article/e6ebd73772e44c50ab5233ebc0ecbd4b