Large-Scale Functional Assessment of Genes Involved in Rare Diseases with Intellectual Disabilities Unravels Unique Developmental and Behaviour Profiles in Mouse Models

Autor: Hamid Meziane, Marie-Christine Birling, Olivia Wendling, Sophie Leblanc, Aline Dubos, Mohammed Selloum, Guillaume Pavlovic, Tania Sorg, Vera M. Kalscheuer, Pierre Billuart, Frédéric Laumonnier, Jamel Chelly, Hans van Bokhoven, Yann Herault

Publikováno v: Biomedicines, Vol 10, Iss 12, p 3148 (2022)

Major progress has been made over the last decade in identifying novel genes involved in neurodevelopmental disorders, although the task of elucidating their corresponding molecular and pathophysiological mechanisms, which are an essential prerequisi

Externí odkaz: https://doaj.org/article/825b189faadd412682f5b1ecc56ac2e3

Ice nucleation in a Gram-positive bacterium isolated from precipitation depends on a polyketide synthase and non-ribosomal peptide synthetase

Autor: Kevin C, Failor, Haijie, Liu, Marco E Mechan, Llontop, Sophie, LeBlanc, Noam, Eckshtain-Levi, Parul, Sharma, Austin, Reed, Shu, Yang, Long, Tian, Christopher T, Lefevre, Nicolas, Menguy, Liangcheng, Du, Caroline L, Monteil, Boris A, Vinatzer

Publikováno v: The ISME journal. 16(3)

Earth's radiation budget and frequency and intensity of precipitation are influenced by aerosols with ice nucleation activity (INA), i.e., particles that catalyze the formation of ice. Some bacteria, fungi, and pollen are among the most efficient ice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1f2ae79cf9334b57eb45b26b863c0b74
https://pubmed.ncbi.nlm.nih.gov/34931029

Metformin in women with type 2 diabetes in pregnancy (MiTy): a multicentre, international, randomised, placebo-controlled trial

Autor: Sora Ludwig, Melissa Deans, Stacey Lacerte, Catherine Young, Kellie E. Murphy, J. Johanna Sanchez, Peter Subrt, David Thompson, Kayla Schutt, George Carson, Bernard Zinman, Thomas Ransom, Melanie Robinson, Minnie Parsons, Shirley Beauchamp, Darlene Baxendale, Afshan Zahedi, Richard Phillips, Natasha Garfield, Paul Karanicolas, Jason Kong, Adriana Breen, Agnieszka Barts, Vincent Wong, Elizabeth Asztalos, Jon Barrett, Heather Belanger, Bonnie Stone-Hope, Josee Champagne, Julie Lambert, Myriam Bouchard, Michele Mahone, Sharon Thompson, Carolyn Oldford, David McIntyre, Dynika St Omer, Raquel Dias, Martin D'Amours, Josephine Laurie, Leila MacBean, Nashwah Taha, Veronica Gale, Wayne Andrews, Heidi Virtanen, Judy Brandt, Heidi Hirsimaki, Mauricio Marin, Gail Klein, Heather Clark, Bernadette Rowe, Joel Ray, Julie Lee, Mark McLean, Siobhan Tobin, Anne-Marie Powell, Janine Malcolm, Paul J. Karanicolas, Claire Gougeon, Leanne De Souza, Elaine O'Shea, Cathy Robb, Marci Turner, Jill Newstead-Angel, Sharon Young, Joan Crane, Leslie Berndl, Simona Meier, Valérie-Ève Julien, Maureen Mattick, Lorraine L. Lipscombe, Simon Tian, Lisa Vizza, Karen Coles, Ken Lim, Razita Singh, Abhay Lodha, George Tomlinson, Shari Segal, Marie-Christine Dubé, Barbara Cleave, Colette Favreau, Howard Berger, Florence Weber, Shital Gandhi, Carol Fergusson, Anthony Armson, Sarah Kwong, Margaret Watson, Michele Strom, George I Fantus, Steve Chalifoux, Ilana Halperin, Anne E. Cook, J Johanna Sanchez, Jillian Coolen, Marnie Nerdal-Bussell, Cheryl Verhesen, Debbie Fong, Marie-Josee Bedard, Susan Hendon, Allison Sigmund, Sara Meltzer, Madalena Neculau, Renee Kludas, Annie Castonguay, Jennifer M. Yamamoto, Bekki Cavallaro, Rshmi Khurana, Effie Viguiliouk, Camille Lambert, Helen R. Murphy, Cora Fanning, Grace Lee, Robyn L. Houlden, Laurie Slater, Eileen K. Hutton, Lorraine Cauchi, Janet Slaunwhite, Prem Lata, Lois E. Donovan, Debbie McGuire, Carolyn Bergan, Aarthi Kamath, Louise Bastien, Sarah Capes, Kathryn Mangoff, Rohit Rajagopal, Anne Tremellen, David Miller, Sophie Perreault, Louise Rheaume, Sherri Pockett, Sophie Leblanc, Christyne Allen, Wenjun Nie, Amira El-Messidi, Edmond A. Ryan, Denice S Feig, Christine Orr, Vinolia ArthurHayward, H. David McIntyre, Ariane Godbout, Denice S. Feig, Jennifer Sloan, Heather Rylance, Simon Yu Tian, Hamish Russell, Sylvie Daigle, Suzanne Williams, Diane Donat, Krista Rideout, Vivian Zhou, Carol Joyce, Krystyna Szwiega, Allan Karovitch, Marie-Claude Bourbonniere, Helen Barrett, Amir Hanna, Tina Kader, Claudia Bishop, I. George Fantus, Ruth McManus, Stephanie Cooper, Jennifer Klinke, Bi Lan Wo, Keitha McMurray, Brenda Galway, S. John Weisnagel, Erin Keely, Jodie Nema, Joyce Mitchell, Hélène Long, Frances Maguire, Alice Cheng, Munira Sultana, Melin Peng, Jane Fox, Evelyne Rey, Francina Carr, Galina Smushkin, Tammy McNab, Maria Wolfs, Helen G. Liley, David Simmons

Publikováno v: The lancet. Diabetesendocrinology. 8(10)

Summary Background Although metformin is increasingly being used in women with type 2 diabetes during pregnancy, little data exist on the benefits and harms of metformin use on pregnancy outcomes in these women. We aimed to investigate the effects of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::948529904de7be95ce75d903d1fc85b9
https://pubmed.ncbi.nlm.nih.gov/33065062

Toward developing pheromone emitting trap crops: metabolic engineering of an aggregation pheromone of the crucifer flea beetle, Phyllotreta cruciferae, in Nicotiana benthamiana

Autor: Sophie LeBlanc

Publikováno v: ASPB PLANT BIOLOGY 2020.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aac0a2aebdfa380d4e78b1f0b660d2d7
https://doi.org/10.46678/pb.20.1052998

Principles and application of LIMS in mouse clinics

Autor: Juan Gallegos, Kimio Kobayashi, Mark Griffiths, Tomohiro Suzuki, Navis Pretheeba Raj, Helmut Fuchs, Holger Maier, Sophie Leblanc, Martin Hrabě de Angelis, David S. Richardson, Rafael Alcantara, Laurent Vasseur, S. Holroyd, Arthur Evans, Shigeharu Wakana, Neha Agrawal, Christine Schütt, Valerie Gailus-Durner, Christian Kipp, Elida Schneltzer, Dave Clary, Ralph Steinkamp, David Melvin, Nobuhiko Tanaka, Christoph Lengger, Hiroshi Masuya, Alison Walling, Philipp Gormanns, David Gannon, Anja Hurt

Publikováno v: Mamm. Genome 26, 467-481 (2015)
Europe PubMed Central
Mammalian Genome

Large-scale systemic mouse phenotyping, as performed by mouse clinics for more than a decade, requires thousands of mice from a multitude of different mutant lines to be bred, individually tracked and subjected to phenotyping procedures according to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f13dd5ffc78ea2158406a9cd0df835
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=46419