Centrally expressed Cav3.2 T-type calcium channel is critical for the initiation and maintenance of neuropathic pain

Autor: Sophie L Fayad, Guillaume Ourties, Benjamin Le Gac, Baptiste Jouffre, Sylvain Lamoine, Antoine Fruquière, Sophie Laffray, Laila Gasmi, Bruno Cauli, Christophe Mallet, Emmanuel Bourinet, Thomas Bessaih, Régis C Lambert, Nathalie Leresche

Publikováno v: eLife, Vol 11 (2022)

Cav3.2 T-type calcium channel is a major molecular actor of neuropathic pain in peripheral sensory neurons, but its involvement at the supraspinal level is almost unknown. In the anterior pretectum (APT), a hub of connectivity of the somatosensory sy

Externí odkaz: https://doaj.org/article/f57da5814bca4f218d1d7debca0045b1

The Low-Threshold Calcium Channel Cav3.2 Determines Low-Threshold Mechanoreceptor Function

Autor: Amaury François, Niklas Schüetter, Sophie Laffray, Juan Sanguesa, Anne Pizzoccaro, Stefan Dubel, Annabelle Mantilleri, Joel Nargeot, Jacques Noël, John N. Wood, Aziz Moqrich, Olaf Pongs, Emmanuel Bourinet

Publikováno v: Cell Reports, Vol 10, Iss 3, Pp 370-382 (2015)

The T-type calcium channel Cav3.2 emerges as a key regulator of sensory functions, but its expression pattern within primary afferent neurons and its contribution to modality-specific signaling remain obscure. Here, we elucidate this issue using a un

Externí odkaz: https://doaj.org/article/ca9045d2366e4c22b04e56cb98ed85f0

Cav3.2 T-type calcium channels shape electrical firing in mouse Lamina II neurons

Autor: Margarita Arango-Lievano, Perrine Inquimbert, Gerald W. Zamponi, Pierre-François Méry, Yves Le Feuvre, Miriam Candelas, Claire Bernat, Ana Reynders, Christoph Neumayer, Emmanuel Bourinet, Aziz Moqrich, Jawed Hamid, Céline Lemmers, Sophie Laffray, Antoine Fruquière, Elsa Demes, Arnaud Monteil, Vincent Compan

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-18 (2019)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-019-39703-3⟩
Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-39703-3⟩

The T-type calcium channel, Cav3.2, is necessary for acute pain perception, as well as mechanical and cold allodynia in mice. Being found throughout sensory pathways, from excitatory primary afferent neurons up to pain matrix structures, it is a prom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::691463aa7c36cbe0c50f6c0dfbcd7f11
http://link.springer.com/article/10.1038/s41598-019-39703-3

T-type calcium channels in neuropathic pain

Autor: Amaury François, Emmanuel Bourinet, Sophie Laffray

Publikováno v: PAIN
PAIN, Elsevier, 2016, 157 Suppl 1, pp.S15--22. ⟨10.1097/j.pain.0000000000000469⟩
PAIN, 2016, 157 Suppl 1, pp.S15--22. ⟨10.1097/j.pain.0000000000000469⟩

Review articles from the 5th International Meeting of the IASP Special Interest Group on Neuropathic Pain (NeuPSIG); International audience; Pain is a quite frequent complaint accompanying numerous pathologies. Among these pathological cases, numerou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cf781cc5949d5c24346ac55e3f789fa
https://hal.archives-ouvertes.fr/hal-01942457

In vivooptical monitoring of tissue pathologies and diseases with vibrational contrast

Autor: Steve Bégin, Réal Vallée, Erik Bélanger, Daniel Côté, Sophie Laffray

Publikováno v: Journal of Biophotonics. 2:632-642

Studies of tissue remodeling require in vivo imaging techniques that are as minimally invasive as possible to avoid microenvironment perturbations. To this end, spontaneous Raman techniques have been used but low signals have limited their applicatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7e64eda025ca86d122cff6126681694
https://doi.org/10.1002/jbio.200910071