Výsledky vyhledávání - "Sophie, Gioria"

SynAggreg: A Multifunctional High-Throughput Technology for Precision Study of Amyloid Aggregation and Systematic Discovery of Synergistic Inhibitor Compounds

Autor: Yvon Trottier, Hélène Nierengarten, Pascal Villa, Hubert Aviolat, Yves Nominé, Anna Bonhoure, Frank Ruffenach, Fabrice A.C. Klein, David Hoffmann, Sophie Gioria, Christine Ruhlmann

Publikováno v: Journal of Molecular Biology
Journal of Molecular Biology, Elsevier, 2018, 430 (24), pp.5257-5279. ⟨10.1016/j.jmb.2018.09.009⟩

Numerous proteins can coalesce into amyloid self-assemblies, which are responsible for a class of diseases called amyloidoses, but which can also fulfill important biological functions and are of great interest for biotechnology. Amyloid aggregation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57f27f6b16e16ad96b54669461ec8833
https://hal.archives-ouvertes.fr/hal-02006902

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The adaptors Grb10 and Grb14 are calmodulin-binding proteins

Autor: Eduardo Villalobo, Noemí Pompas-Veganzones, Irene García-Palmero, Antonio Villalobo, Sophie Gioria, Jacques Haiech

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
idUS. Depósito de Investigación de la Universidad de Sevilla

We identified the Grb7 family members, Grb10 and Grb14, as Ca2+ -dependent CaM-binding proteins using Ca2+ -dependent CaM-affinity chromatography as we previously did with Grb7. The potential CaM-binding sites were identified and experimentally teste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0405d4d94b66c031cacbac0e6576e156
https://pubmed.ncbi.nlm.nih.gov/28295264

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Identification of Nonpeptide Oxytocin Receptor Ligands by Receptor-Ligand Fingerprint Similarity Search

Autor: Christel Valencia, Pascal Villa, Didier Rognan, Marcel Hibert, Nathanael Weill, Sophie Gioria

Publikováno v: Molecular Informatics. 30:521-526

Oxytocin (OT) is a peptide hormone secreted by the pituitary gland that binds to a specific G protein-coupled receptor (OTR) to mediate both peripheral and central actions. It notably induces uterine contraction during labor and stimulates lactation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11bf44762b13dd655bb96c24dffa1e32
https://doi.org/10.1002/minf.201100026

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A general strategy to characterize calmodulin–calcium complexes involved in CaM–target recognition: DAPK and EGFR calmodulin binding domains interact with different calmodulin–calcium complexes

Autor: Marie Fève, Claire Pigault, Jacques Haiech, Rania Dagher, Michael B. Zimmermann, Marie-Claude Kilhoffer, Maria Zeniou, Shan Peng, Sophie Gioria

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1813(5):1059-1067

Calmodulin (CaM) is a ubiquitous Ca2+ sensor regulating many biochemical processes in eukaryotic cells. Its interaction with a great variety of different target proteins has led to the fundamental question of its mechanism of action. CaM exhibits fou

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New aspects of calmodulin-calmodulin binding domains recognition

Autor: Emilie, Audran, Rania, Dagher, Sophie, Gioria, Marie-Claude, Kilhoffer, Jacques, Haiech

Publikováno v: Methods in molecular biology (Clifton, N.J.). 963

Understanding the role of calmodulin (CaM) in calcium signal transduction implies to describe the -calcium-dependent molecular mechanism of interaction of CaM with the various CaM-binding domains (CBD). In order to fulfill this aim, we have developed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c17ad6bb1ee661e1a4230c5f2eefd0da
https://pubmed.ncbi.nlm.nih.gov/23296604

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New Aspects of Calmodulin–Calmodulin Binding Domains Recognition

Autor: Rania Dagher, Sophie Gioria, Marie-Claude Kilhoffer, Jacques Haiech, Emilie Audran

Publikováno v: Methods in Molecular Biology ISBN: 9781627032292

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2df42021966e244dfeee33c784d0ef8d
https://doi.org/10.1007/978-1-62703-230-8_4

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FRET and colocalization analyzer--a method to validate measurements of sensitized emission FRET acquired by confocal microscopy and available as an ImageJ Plug-in

Autor: Jean-Luc Galzi, Olivier Marchal, Hans W. D. Matthes, Sophie Gioria, Noël Converset, Muriel Hachet-Haas, Sandra Lecat

Publikováno v: Microscopy Research and Technique
Microscopy Research and Technique, Wiley, 2006, 69 (12), pp.941-56. ⟨10.1002/jemt.20376⟩

Fluorescence resonance energy transfer (FRET) between an adequate pair of fluorophores is an indication of closer proximity than colocalization and is used by biologists to study fluorescently modified protein interactions inside cells. We present a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d620dc0392140f06c44a5a88127dec5a
https://hal.archives-ouvertes.fr/hal-00174042

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A general framework to characterize inhibitors of calmodulin: Use of calmodulin inhibitors to study the interaction between calmodulin and its calmodulin binding domains

Autor: Emilie Audran, Sophie Gioria, Bruno Didier, Marie-Claude Kilhoffer, Philipp O. Tsvetkov, Rania Dagher, Alexandra A. Kulikova, Pascal Villa, Jacques Haiech, Alexander A. Makarov

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. (7):1720-1731

The prominent role of Ca 2 + in cell physiology is mediated by a whole set of proteins involved in Ca 2 + -signal generation, deciphering and arrest. Among these intracellular proteins, calmodulin (CaM) known as a prototypical calcium sensor, serves

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