SOD1-related ALS with anticipation in a large family from Martinique

Autor: Rémi Bellance, Cyril Goizet, Thomas Barnetche, Séverine Jeannin, Cécile Cazeneuve, Pascale Olive, Fabienne Clot, Sophie Duclos, Juliette Smith-Ravin, Anna-Gaelle Giguet-Valard, Oriane Allard-Saint-Albin, Pittion-Vouyovitch Sophie

Publikováno v: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Taylor & Francis, 2021, ⟨10.1080/21678421.2021.1900870⟩

Amyotrophic Lateral Sclerosis (ALS) is a rare neurological disorder that causes degeneration of upper and lower motor neurons and their axons. ALS is mostly sporadic, but there are familial forms. In more than half of the familial forms, a pathogenic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de3dfc8c3cac803d80dfd54d1847e155
https://hal.archives-ouvertes.fr/hal-03404622

Remodeling of endosomes during lysosome biogenesis involves 'kiss and run' fusion events regulated by rab5

Autor: Rachel Corsini, Sophie Duclos, Michel Desjardins

Publikováno v: Journal of Cell Science. 116:907-918

The small GTPase rab5 has been shown to play key roles in the function of both endocytic and phagocytic organelles. Although these organelles share several additional common features, different processes have been proposed to explain their biogenesis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c9ed074371d3a6d4ed34209dbfbdf7b
https://doi.org/10.1242/jcs.00259

Rab5 regulates the kiss and run fusion between phagosomes and endosomes and the acquisition of phagosome leishmanicidal properties in RAW 264.7 macrophages

Autor: Barbara Papadopoulou, J. Garin, Michel Desjardins, Albert Descoteaux, Harald Stenmark, Roberto Diez, Sophie Duclos

Publikováno v: Journal of Cell Science. 113:3531-3541

Phagolysosome biogenesis is essential for the killing and degradation of intracellular pathogens. It involves the fusion of phagosomes with various endocytic organelles, a process known to be regulated in part by Rab proteins. We generated RAW 264.7

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cf0afaf64540d21d614a44f4de31ebc
https://doi.org/10.1242/jcs.113.19.3531

Proteomic Characterization of Phagosomal Membrane Microdomains During Phagolysosome Biogenesis and Evolution*

Autor: Jean-François Dermine, Sylvie Laboissiere, Isabelle Jutras, Pierre Thibault, Sophie Duclos, Jonathan Boulais, Stephen W. Michnick, Christian R. Landry, Luis B. Barreiro, Gilles A. Lajoie, Michel Desjardins, Guillaume Goyette, Nicholas J. Carruthers

After their formation at the cell surface, phagosomes become fully functional through a complex maturation process involving sequential interactions with various intracellular organelles. In the last decade, series of data indicated that some of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::813903d6c1f8f009636eaa4a9b727086
https://europepmc.org/articles/PMC3494184/

Organelle proteomics

Autor: Sophie, Duclos, Michel, Desjardins

Publikováno v: Methods in molecular biology (Clifton, N.J.). 753

Proteomics has significantly contributed to improve our understanding of cell structures and functions in the last decade. The possibility to identify large sets of proteins from minute amount of material, linked with the isolation of cellular organe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a27f7c7134045c0a2f921c0bca2ad7ae
https://pubmed.ncbi.nlm.nih.gov/21604119