Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Sophia-Marie Hartmann"'
Autor:
Johanna Heider, Emilio Pardo González, Sophia-Marie Hartmann, Nirmal Kannaiyan, Sabrina Vogel, Richard Wüst, Andreas J. Fallgatter, Moritz J. Rossner, Udo Kraushaar, Hansjürgen Volkmer
Publikováno v:
Neurobiology of Disease, Vol 201, Iss , Pp 106678- (2024)
Schizophrenia (SCZ) is a psychiatric disorder with a strong genetic determinant. A major hypothesis to explain disease aetiology comprises synaptic dysfunction associated with excitatory-inhibitory imbalance of synaptic transmission, ultimately contr
Externí odkaz:
https://doaj.org/article/5d3a1f85a2f0489fb106cbce8f0988f6
Autor:
Johanna Heider, Aaron Stahl, Denise Sperlich, Sophia-Marie Hartmann, Sabrina Vogel, Ricarda Breitmeyer, Markus Templin, Hansjürgen Volkmer
Publikováno v:
BMC Neuroscience, Vol 25, Iss 1, Pp 1-20 (2024)
Abstract Background Mutations in the gene DISC1 are associated with increased risk for schizophrenia, bipolar disorder and major depression. The study of mutated DISC1 represents a well-known and comprehensively characterized approach to understand n
Externí odkaz:
https://doaj.org/article/1113a8edc4e34a2a87fef4ae3a9fb152
Autor:
Sophia-Marie Hartmann, Johanna Heider, Richard Wüst, Andreas J. Fallgatter, Hansjürgen Volkmer
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Multiple lines of evidence implicate increased neuroinflammation mediated by glial cells to play a key role in neurodevelopmental disorders such as schizophrenia. Microglia, which are the primary innate immune cells of the brain, are crucial for the
Externí odkaz:
https://doaj.org/article/ef913ad2930549f6bd64fe2292cd9e8d
Regulation of synaptic connectivity in schizophrenia spectrum by mutual neuron-microglia interaction
Autor:
Ricarda Breitmeyer, Sabrina Vogel, Johanna Heider, Sophia-Marie Hartmann, Richard Wüst, Anna-Lena Keller, Anna Binner, Julia C. Fitzgerald, Andreas J. Fallgatter, Hansjürgen Volkmer
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-16 (2023)
Abstract The examination of post-mortem brain tissue suggests synaptic loss as a central pathological hallmark of schizophrenia spectrum (SCZ), which is potentially related to activated microglia and increased inflammation. Induced pluripotent stem c
Externí odkaz:
https://doaj.org/article/1df2e8cc9f874ebdb70e23e08beb33b9
Autor:
Stefan Liebau, Udo Maier, Natalia Pashkovskaia, Stefan Kauschke, Peter Loskill, Alexander Kleger, Julia Roosz, Birgit Stierstorfer, Lena Mesch, Johanna Chuchuy, Matthias J. Düchs, Selin Pars, Sebastian Kreuz, Sophia-Marie Hartmann, Kevin Achberger, Virginia Cora, Madalena Cipriano, Stefan Michelfelder, Christian Schön, Thorsten Lamla, Serena Corti
Publikováno v:
Stem Cell Reports
Summary Gene therapies using adeno-associated viruses (AAVs) are among the most promising strategies to treat or even cure hereditary and acquired retinal diseases. However, the development of new efficient AAV vectors is slow and costly, largely bec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8e1c1e22c62fe5b3bca7a65054cbdb2
https://doi.org/10.1016/j.stemcr.2021.08.008
https://doi.org/10.1016/j.stemcr.2021.08.008