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pro vyhledávání: '"Sophia W Li"'
Autor:
Sophia W Li, Meredith Wright, John F Healey, Jennie M Hutchinson, Sara O'Rourke, Kathryn A Mesa, Pete Lollar, Phillip W Berman
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233866 (2020)
Several candidate HIV subunit vaccines based on recombinant envelope (Env) glycoproteins have been advanced into human clinical trials. To facilitate biopharmaceutical production, it is necessary to produce these in CHO (Chinese Hamster Ovary) cells,
Externí odkaz:
https://doaj.org/article/5aa34ecd6bb14d1a9e078ad96c29c7f1
Autor:
Meredith Wright, Kathryn A. Mesa, Bin Yu, Phillip W. Berman, Gabriel Byrne, Sara M. O'Rourke, Sophia W Li
Publikováno v:
Biotechnology and Bioengineering. 116:2130-2145
Proteolysis associated with recombinant protein expression in Chinese Hamster Ovary (CHO) cells has hindered the development of biologics including HIV vaccines. When expressed in CHO cells, the recombinant HIV envelope protein, gp120, undergoes prot