Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Sophia V Pavlova"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8695 (2024)
Hypertrophic cardiomyopathy (HCM) is a cardiovascular pathology that is caused by variants in genes encoding sarcomere-associated proteins. However, the clinical significance of numerous variants in HCM-associated genes is still unknown. CRISPR/Cas9
Externí odkaz:
https://doaj.org/article/c47c5e71b5be4defb58777b4c7d7618f
Autor:
Elena S. Yarkova, Elena V. Grigor’eva, Sergey P. Medvedev, Denis A. Tarasevich, Sophia V. Pavlova, Kamila R. Valetdinova, Julia M. Minina, Suren M. Zakian, Anastasia A. Malakhova
Publikováno v:
Biomedicines, Vol 12, Iss 4, p 744 (2024)
Endoplasmic reticulum (ER) stress is involved in the pathogenesis of many human diseases, such as cancer, type 2 diabetes, kidney disease, atherosclerosis and neurodegenerative diseases, in particular Parkinson’s disease (PD). Since there is curren
Externí odkaz:
https://doaj.org/article/40ac1f132b0c46d1bfe312659914ee7f
Autor:
Elena S. Yarkova, Elena V. Grigor’eva, Sergey P. Medvedev, Sophia V. Pavlova, Suren M. Zakian, Anastasia A. Malakhova
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 327 (2023)
Parkinson’s disease (PD) is a neurodegenerative disorder that ranks second in prevalence after Alzheimer’s disease. The number of PD diagnoses increases annually. Nevertheless, modern PD treatments merely mitigate symptoms rather than preventing
Externí odkaz:
https://doaj.org/article/4e47ad45cc044c648b1e5408ea4481b5
Autor:
Elizaveta Ustyantseva, Sophia V. Pavlova, Anastasia A. Malakhova, Kirill Ustyantsev, Suren M. Zakian, Sergey P. Medvedev
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Oxidative stress plays an important role in the development of neurodegenerative diseases, being either the initiator or part of a pathological cascade that leads to the neuron’s death. Genetically encoded biosensors of oxidative stress de
Externí odkaz:
https://doaj.org/article/5953b08d365647b29b35b70e9005d51f
Autor:
Elena V. Chepeleva, Sophia V. Pavlova, Nataliya P. Bgatova, Alexander M. Volkov, Galina M. Kazanskaya, David S. Sergeevichev
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 12, p 9792 (2023)
In the treatment of coronary heart disease, the most promising approach for replacing lost contractile elements involves obtaining cardiomyocytes through cardiac differentiation of pluripotent cells. The objective of this study is to develop a techno
Externí odkaz:
https://doaj.org/article/0648798a8a274049ab92455c7bd62e64
Autor:
Nadezhda S. Dyrkheeva, Anastasia A. Malakhova, Aleksandra L. Zakharenko, Larisa S. Okorokova, Dmitriy N. Shtokalo, Sophia V. Pavlova, Sergey P. Medvedev, Suren M. Zakian, Anna A. Nushtaeva, Alexey E. Tupikin, Marsel R. Kabilov, Svetlana N. Khodyreva, Olga A. Luzina, Nariman F. Salakhutdinov, Olga I. Lavrik
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5148 (2023)
Topoisomerase 1 (TOP1) is an enzyme that regulates DNA topology and is essential for replication, recombination, and other processes. The normal TOP1 catalytic cycle involves the formation of a short-lived covalent complex with the 3′ end of DNA (T
Externí odkaz:
https://doaj.org/article/ed3c358c6ece453bb1250e334bb40dbb
Autor:
Elena V. Grigor’eva, Alena E. Kopytova, Elena S. Yarkova, Sophia V. Pavlova, Diana A. Sorogina, Anastasia A. Malakhova, Tuyana B. Malankhanova, Galina V. Baydakova, Ekaterina Y. Zakharova, Sergey P. Medvedev, Sofia N. Pchelina, Suren M. Zakian
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4437 (2023)
GBA variants increase the risk of Parkinson’s disease (PD) by 10 times. The GBA gene encodes the lysosomal enzyme glucocerebrosidase (GCase). The p.N370S substitution causes a violation of the enzyme conformation, which affects its stability in the
Externí odkaz:
https://doaj.org/article/365091594fc848809889675d20533582
Autor:
Sergeevichev, Elena V. Chepeleva, Sophia V. Pavlova, Nataliya P. Bgatova, Alexander M. Volkov, Galina M. Kazanskaya, David S.
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 12; Pages: 9792
In the treatment of coronary heart disease, the most promising approach for replacing lost contractile elements involves obtaining cardiomyocytes through cardiac differentiation of pluripotent cells. The objective of this study is to develop a techno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::8b3c64e017afb49ea8334777f8848438
Autor:
Elizaveta, Ustyantseva, Sophia V, Pavlova, Anastasia A, Malakhova, Kirill, Ustyantsev, Suren M, Zakian, Sergey P, Medvedev
Publikováno v:
Scientific reports. 12(1)
Oxidative stress plays an important role in the development of neurodegenerative diseases, being either the initiator or part of a pathological cascade that leads to the neuron's death. Genetically encoded biosensors of oxidative stress demonstrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e09c0244c8d4178e1012134ec08d3506
https://pubmed.ncbi.nlm.nih.gov/35624228
https://pubmed.ncbi.nlm.nih.gov/35624228
Autor:
Evgeniya A Vaskova, Elena V Dementyeva, Alexander I Shevchenko, Sophia V Pavlova, Elena V Grigor'eva, Antonina I Zhelezova, John L Vandeberg, Suren M Zakian
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88256 (2014)
In rodent female mammals, there are two forms of X-inactivation - imprinted and random which take place in extraembryonic and embryonic tissues, respectively. The inactive X-chromosome during random X-inactivation was shown to contain two types of fa
Externí odkaz:
https://doaj.org/article/c9317183ee0b474e83fefd37577ab49c