Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sophia T. Mundle"'
Autor:
Jennifer N. Rainho-Tomko, Vincent Pavot, Michael Kishko, Kurt Swanson, Darin Edwards, Heesik Yoon, Lilibeth Lanza, Judith Alamares-Sapuay, Robert Osei-Bonsu, Sophia T. Mundle, Dave A. Murison, Scott Gallichan, Simon Delagrave, Chih-Jen Wei, Linong Zhang, Gary J. Nabel
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-9 (2022)
Abstract Respiratory syncytial virus (RSV) G glycoprotein has recently reemerged as a vaccine antigen due to its ability to elicit potent neutralizing antibodies and ameliorate disease in animal models. Here we designed three constructs to display th
Externí odkaz:
https://doaj.org/article/ebfed4caf551425eb43d4a04f2b4e65f
Autor:
Jinyu Liu, Michael Kothe, Jianxin Zhang, Eliud Oloo, Svetlana Stegalkina, Sophia T. Mundle, Lu Li, Jinrong Zhang, Leah E. Cole, Lucianna Barone, Hans-Peter Biemann, Harry Kleanthous, Natalie G. Anosova, Stephen F. Anderson
Publikováno v:
Current Research in Structural Biology, Vol 4, Iss , Pp 96-105 (2022)
Clostridium difficile toxins are the primary causative agents for hospital-acquired diarrhea and pseudomembranous colitis. Numerous monoclonal antibodies (mAbs) targeting different domains of Clostridium difficile toxin have been reported. Here we re
Externí odkaz:
https://doaj.org/article/376b5155381642f9bbe8724343d7e516
Autor:
Sudha Chivukula, Timothy Plitnik, Timothy Tibbitts, Shrirang Karve, Anusha Dias, Donghui Zhang, Rebecca Goldman, Hardip Gopani, Asad Khanmohammed, Ashish Sarode, Dustin Cooper, Heesik Yoon, Younghoon Kim, Yanhua Yan, Sophia T. Mundle, Rachel Groppo, Adrien Beauvais, Jinrong Zhang, Natalie G. Anosova, Charles Lai, Lu Li, Gregory Ulinski, Peter Piepenhagen, Joshua DiNapoli, Kirill V. Kalnin, Victoria Landolfi, Ron Swearingen, Tong-Ming Fu, Frank DeRosa, Danilo Casimiro
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-15 (2021)
Abstract Recent approval of mRNA vaccines for emergency use against COVID-19 is likely to promote rapid development of mRNA-based vaccines targeting a wide range of infectious diseases. Compared to conventional approaches, this vaccine modality promi
Externí odkaz:
https://doaj.org/article/a7de43f864854e63ba72ae5665205ec9
Autor:
Scott A. Rush, Gurpreet Brar, Ching-Lin Hsieh, Emilie Chautard, Jennifer N. Rainho-Tomko, Chris D. Slade, Christine A. Bricault, Ana Kume, James Kearns, Rachel Groppo, Sophia T. Mundle, Linong Zhang, Danilo Casimiro, Tong-Ming Fu, Joshua M. DiNapoli, Jason S. McLellan
Publikováno v:
Cell reports. 40(12)
Human metapneumovirus (hMPV) is a major cause of acute respiratory tract infections in infants and the elderly for which there are no approved vaccines or antibody therapies. The viral fusion (F) glycoprotein is required for entry and is the primary
Publikováno v:
Biochemistry. 48(1)
The endonucleolytic activity of human apurinic/apyrimidinic endonuclease (AP endo) is a major factor in the maintenance of the integrity of the human genome. There are estimates that this enzyme is responsible for eliminating as many as 10(5) potenti
Autor:
Sophia T. Mundle, Alexandros Makriyannis, Carlos de los Santos, Phyllis R. Strauss, Jianxin Guo
Publikováno v:
The FASEB Journal. 20
Autor:
Luisa F. Melo, Sophia T. Mundle, Jean D. Coriolan, N. Edel O’Regan, Michael H. Fattal, Phyllis R. Strauss
Publikováno v:
DNA repair. 3(11)
Apurinic/apyrimidinic endonuclease (AP endo, HAP1) recognizes abasic sites in ds DNA and makes a single nick in the backbone 5' to the abasic site. In this report we examine the roles of three conserved tyrosine residues in close proximity to the act
Autor:
N. Edel O’Regan, Jean D. Coriolan, Luisa F. Melo, Sophia T. Mundle, Michael H. Fattal, Phyllis R. Strauss
Publikováno v:
DNA Repair. 4:521-522
Autor:
Sophia T Mundle, Hector Hernandez, John Hamberger, John Catalan, Changhong Zhou, Svetlana Stegalkina, Andrea Tiffany, Harry Kleanthous, Simon Delagrave, Stephen F Anderson
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57224 (2013)
Genital herpes is a sexually transmitted infection (STI) caused by herpes simplex virus 2 (HSV-2) and to a lesser extent herpes simplex virus 1 (HSV-1). Infection by HSV-2 is life-long and is associated with significant cost to healthcare systems and
Externí odkaz:
https://doaj.org/article/d67d7fbcea1545a78cf5d2f5c0f3bbb7
Autor:
Simon Delagrave, Hector Hernandez, Changhong Zhou, John F Hamberger, Sophia T Mundle, John Catalan, Simge Baloglu, Stephen F Anderson, Joshua M DiNapoli, Patricia Londoño-Hayes, Mark Parrington, Jeffrey Almond, Harry Kleanthous
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46714 (2012)
Herpes simplex virus type 2 (HSV-2) is a sexually transmitted virus that is highly prevalent worldwide, causing a range of symptoms that result in significant healthcare costs and human suffering. ACAM529 is a replication-defective vaccine candidate
Externí odkaz:
https://doaj.org/article/c5ec100bcc5544109ee42bf24ad11d78