Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Sophia Soehrman"'
Publikováno v:
Cell Motility and the Cytoskeleton. 63:681-695
In neurons, the regulation of microtubules plays an important role for neurite outgrowth, axonal elongation, and growth cone steering. SCG10 family proteins are the only known neuronal proteins that have a strong destabilizing effect, are highly enri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b53e7c62b8a2bd769999f635f4471b1d
https://doi.org/10.1002/cm.20154
https://doi.org/10.1002/cm.20154
Publikováno v:
Journal of Neurobiology. 58:60-69
The related proteins SCG10 and stathmin are highly expressed in the developing nervous system. Recently it was discovered that they are potent microtubule destabilizing factors. While stathmin is expressed in a variety of cell types and shows a cytos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b4bc766822f387fad0e659d068d408c
https://doi.org/10.1002/neu.10279
https://doi.org/10.1002/neu.10279
Autor:
Desamparados Roda, Farzin Farzaneh, Josep Tabernero, Andrés Cervantes, Yann Berge, Jean-Pierre Delord, Alexandre Passioukov, David Oppenheim, Carlos Gomez-Roca, Luigi Manenti, Paul Delmar, Sophia Soehrman Brossard, Jean-Charles Soria, Rocio Garcia-Carbonero, Luis Paz-Ares, Marion Gabriele Ott, Jaume Capdevila
Publikováno v:
European journal of cancer (Oxford, England : 1990). 50(3)
Aim Imgatuzumab (GA201) is a novel anti-epidermal growth factor receptor (anti-EGFR) antibody glycoengineered for enhanced antibody-dependent cell-mediated cytotoxicity (ADCC). We investigated the efficacy of imgatuzumab in patients with EGFR-positiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48720e2b2d86ca3e6e04f1fe12dceffa
https://pubmed.ncbi.nlm.nih.gov/24262587
https://pubmed.ncbi.nlm.nih.gov/24262587
Autor:
Ulrik Lassen, Jose M. Saro Suarez, Josep Tabernero, Catharina Wilhelmina Menke, Emilie M.J. van Brummelen, Jose Luis Perez Gracia, George Coukos, Solange Romagnoli, Jan H.M. Schellens, Heikki Joensuu, Krisztian Homicsko, Ignacio Melero, Guillem Argiles, Sophia Soehrman Brossard, Morten Dræby Sørensen, Stefan Evers, Henk M.W. Verheul, Eric Angevin, Tapan K. Nayak, Bernhard Reis
Publikováno v:
Journal of Clinical Oncology. 33:3016-3016
3016 Background: CEA-IL2v (RG7813) is an engineered IL-2 variant (IL-2v) with abolished IL-2Rα (CD25) binding fused to an antibody targeting Carcinoembryonic Antigen (CEA). The molecule was designe...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::554bdc2b1a5cf22137d9b5c66b7369c2
https://doi.org/10.1200/jco.2015.33.15_suppl.3016
https://doi.org/10.1200/jco.2015.33.15_suppl.3016
During development, EphB proteins serve as axon guidance molecules for retinal ganglion cell axon pathfinding toward the optic nerve head and in midbrain targets. To better understand the mechanisms by which EphB proteins influence retinal growth con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99aea7e0f6aaafcafcbd92af6d0c185b
https://europepmc.org/articles/PMC6730397/
https://europepmc.org/articles/PMC6730397/
Akademický článek
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Autor:
Alexandre Passioukov, Jean-Charles Soria, Jean-Pierre Jeannon, Paul Delmar, Carlos Gomez-Roca, Jean-Pierre Delord, Yann Berge, James Spicer, Sophia Soehrman Brossard, Sophie Golding, Stéphane Temam, Luigi Manenti, David Oppenheim
Publikováno v:
Journal of Clinical Oncology. 30:5522-5522
5522 Background: GA201 efficacy was superior to C in orthotopic xenograft models in terms of activity and PD. In a phase I study, objective responses and long lasting stable disease were observed in heavily pre-treated patients (pts). Methods: HNSCC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfea56c7cc17194a1cbfb16ba90eed56
https://doi.org/10.1200/jco.2012.30.15_suppl.5522
https://doi.org/10.1200/jco.2012.30.15_suppl.5522
Autor:
Christoph Mancao, David Oppenheim, Ben Markman, David Carlile, Giuseppe Aprile, Antonio Cubillo, Salvatore Siena, Sophia Soehrman, John Bridgewater, Chrstian Gerdes, Jon Chick, Alexandre Passioukov, Josep Tabernero, Luigi Manenti, Carles Pericay, Jean-Charles Soria, Maria Longauer Banholzer, Andrés Cervantes, L. Arés, Stéphane Temam, Sophie Golding, Ashita Waterston
Publikováno v:
Cancer Research. 72:LB-220
GA201 is a novel dual-acting humanized, engineered IgG1 anti-EGFR mAb designed to enhance ADCC in combination with signaling inhibition. Superior efficacy was demonstrated versus cetuximab in orthotopic CRC xenograft models. Preclinical data indicate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d1b9f3ff137f7949b412aed9ea88d78
https://doi.org/10.1158/1538-7445.am2012-lb-220
https://doi.org/10.1158/1538-7445.am2012-lb-220
Publikováno v:
Cell Motility & the Cytoskeleton; Nov2006, Vol. 63 Issue 11, p681-695, 15p
Publikováno v:
Journal of Neurobiology; Jan2004, Vol. 58 Issue 1, p60-69, 10p