Implantation of engineered human microvasculature to study human infectious diseases in mouse models

Autor: Sophia Schönherr-Hellec, Eirini Chatzopoulou, Jean-Philippe Barnier, Yoann Atlas, Sébastien Dupichaud, Thomas Guilbert, Yves Dupraz, Julie Meyer, Catherine Chaussain, Caroline Gorin, Xavier Nassif, Stephane Germain, Laurent Muller, Mathieu Coureuil

Publikováno v: iScience, Vol 26, Iss 4, Pp 106286- (2023)

Summary: Animal models for studying human pathogens are crucially lacking. We describe the implantation in mice of engineered human mature microvasculature consisting of endothelial and perivascular cells embedded in collagen hydrogel that allows inv

Externí odkaz: https://doaj.org/article/42dd2748dbfa4182b28a846f68f9536c

The minor pilin PilV provides a conserved adhesion site throughout the antigenically variable meningococcal type IV pilus

Autor: Philippe Morand, Lisa Craig, Subramania Kolappan, Marion Dupuis, Jean-Philippe Barnier, Haniaa Bouzinba-Segard, Julie Meyer, Emmanuelle Bille, Taliah Schmitt, Eric Frapy, Elena Capel, Gaël Gesbert, Sophia Schönherr-Hellec, Anne Jamet, Sandrine Bourdoulous, Xavier Nassif, Zoé Virion, Mathieu Coureuil

Publikováno v: Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (45), pp.e2109364118. ⟨10.1073/pnas.2109364118⟩

International audience; Neisseria meningitidis utilizes type IV pili (T4P) to adhere to and colonize host endothelial cells, a process at the heart of meningococcal invasive diseases leading to meningitis and sepsis. T4P are polymers of an antigenica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::380344cc6b67faa3a165f2f12f1676c1
https://pubmed.ncbi.nlm.nih.gov/34725157

Airway Mucus Restricts Neisseria meningitidis Away from Nasopharyngeal Epithelial Cells and Protects the Mucosa from Inflammation

Autor: Alain Schmitt, Bruno Saubaméa, Renaud Léonard, Benoit Gachet, Catherine Robbe-Masselot, Xavier Nassif, Mathieu Coureuil, Mathilde Audry, Jean-Philippe Barnier, Sophia Schönherr-Hellec

Publikováno v: mSphere, Vol 4, Iss 6, p e00494-19 (2019)
mSphere, Vol 4, Iss 6 (2019)
mSphere
mSphere, 2019, mSphere, 4 (6), ⟨10.1128/msphere.00494-19⟩

The work presented by Audry et al. (M. Audry, C. Robbe-Masselot, J.-P. Barnier, B. Gachet, et al., mSphere 4:e00494-19, 2019, https://doi.org/10.1128/mSphere.00494-19) gives new insight into the interactions of Neisseria meningitidis and the human na

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f5cd710866d40fd7012a8047c885aa9
http://hdl.handle.net/20.500.12210/36893

Clostridia and necrotizing enterocolitis in preterm neonates

Autor: Julio Aires, Sophia Schönherr-Hellec

Publikováno v: Anaerobe
Anaerobe, Elsevier Masson, 2019, 58, pp.6-12. ⟨10.1016/j.anaerobe.2019.04.005⟩

Necrotizing enterocolitis (NEC) is the most severe life threatening gastrointestinal disease among preterm neonates. NEC continues to account for substantial morbidity and mortality in neonatal intensive care units worldwide. Although its pathogenesi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e016222b5dcfd1dca4abd4e6c395852b
https://pubmed.ncbi.nlm.nih.gov/30980889

Type IV pilus retraction enables sustained bacteremia and plays a key role in the outcome of meningococcal sepsis in a humanized mouse model.

Autor: Jean-Philippe Barnier, Daniel Euphrasie, Olivier Join-Lambert, Mathilde Audry, Sophia Schonherr-Hellec, Taliah Schmitt, Sandrine Bourdoulous, Mathieu Coureuil, Xavier Nassif, Mohamed El Behi

Publikováno v: PLoS Pathogens, Vol 17, Iss 2, p e1009299 (2021)

Neisseria meningitidis (the meningococcus) remains a major cause of bacterial meningitis and fatal sepsis. This commensal bacterium of the human nasopharynx can cause invasive diseases when it leaves its niche and reaches the bloodstream. Blood-borne

Externí odkaz: https://doaj.org/article/864a8c380c5e49d1960ec60cf1118830