Výsledky vyhledávání - "Sophia Mundle"

Akademický článek

Impact of age and pre-existing influenza immune responses in humans receiving split inactivated influenza vaccine on the induction of the breadth of antibodies to influenza A strains.

Autor: Ivette A Nuñez, Michael A Carlock, James D Allen, Simon O Owino, Krissy K Moehling, Patricia Nowalk, Michael Susick, Kensington Diagle, Kristen Sweeney, Sophia Mundle, Thorsten U Vogel, Simon Delagrave, Moti Ramgopal, Richard K Zimmerman, Harry Kleanthous, Ted M Ross

Publikováno v: PLoS ONE, Vol 12, Iss 11, p e0185666 (2017)

Most humans have pre-existing immunity to influenza viruses. In this study, volunteers (ages of 18-85 years) were vaccinated with split, inactivated Fluzone™ influenza vaccine in four consecutive influenza seasons from 2013 to 2016 seasons. The imp

Externí odkaz: https://doaj.org/article/a438a754d3ea4897889436d329266ab1

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Deciphering the domain specificity of C. difficile toxin neutralizing antibodies

Autor: Lucianna Barone, Kristl M Pacheco, Lu Li, Fuqin Ma, Christopher Rogers, Utsav Jetley, Yanhua Yan, Nicola Beltraminelli, Laurence Quemeneur, Leah E. Cole, Jinrong Zhang, Harry Kleanthous, Natalie G. Anosova, Stephen Anderson, Sophia Mundle, Jianxin Zhang

Publikováno v: Vaccine. 37:3892-3901

Clostridium difficile infection (CDI) is the principal cause of nosocomial diarrhea and pseudomembranous colitis associated with antibiotic therapy. The pathological effects of CDI are primarily attributed to toxins A (TcdA) and B (TcdB). Adequate to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::992883bcc614bec8ec9d5fb502976504
https://doi.org/10.1016/j.vaccine.2019.05.040

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A Combination of Three Fully Human Toxin A- and Toxin B-Specific Monoclonal Antibodies Protects against Challenge with Highly Virulent Epidemic Strains of Clostridium difficile in the Hamster Model

Autor: Pierre Garrone, Satyajit Ray, Nicola Bertraminelli, Lu Li, Sophia Mundle, Stephen Anderson, Jianxin Zhang, Harry Kleanthous, Anna M. Brown, Natalie G. Anosova, Leah E. Cole, Jinrong Zhang, Fuqin Ma

Publikováno v: Clinical and Vaccine Immunology. 22:711-725

Clostridium difficileinfection (CDI) is the principal cause of nosocomial diarrhea and pseudomembranous colitis associated with antibiotic therapy. Recent increases in the number of outbreaks attributed to highly virulent antibiotic-resistant strains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6648a697ae1fee700473ec51b0ac3e0f
https://doi.org/10.1128/cvi.00763-14

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Impact of age and pre-existing influenza immune responses in humans receiving split inactivated influenza vaccine on the induction of the breadth of antibodies to influenza A strains

Autor: Moti Ramgopal, Richard K. Zimmerman, Michael Susick, Harry Kleanthous, Kristen D. Sweeney, Krissy K. Moehling, Sophia Mundle, Simon Delagrave, James D. Allen, Ted M. Ross, Ivette A. Nuñez, Simon O. Owino, Thorsten U. Vogel, Kensington Diagle, Patricia Nowalk, Michael A. Carlock

Publikováno v: PLoS ONE
PLoS ONE, Vol 12, Iss 11, p e0185666 (2017)

Most humans have pre-existing immunity to influenza viruses. In this study, volunteers (ages of 18–85 years) were vaccinated with split, inactivated Fluzone™ influenza vaccine in four consecutive influenza seasons from 2013 to 2016 seasons. The i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1b03dc973b6fe2349df1dad5d0bc598
https://pubmed.ncbi.nlm.nih.gov/29091724

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Core bead chromatography for preparation of highly pure, infectious respiratory syncytial virus in the negative purification mode

Autor: John Hamberger, Sophia Mundle, Rachel Groppo, Mark Parrington, Harry Kleanthous, Stephen Anderson, Joshua M. DiNapoli, Linong Zhang, Michael G. Kishko, Bryan McNeil

Publikováno v: Vaccine. 34(32)

Respiratory syncytial virus (RSV) is an important human pathogen, and is the most frequent viral cause of severe respiratory disease in infants. In addition, it is increasingly being recognized as an important cause of respiratory disease in the elde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::269966b1d46a20aac5165b447aeda1fe
https://pubmed.ncbi.nlm.nih.gov/27238375

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Increasing Domain Coverage Improves Neutralizing Potency of C. difficile Toxin-specific Antibodies

Autor: Lu Li, Leah E. Cole, Utsav Jetley, Jinrong Zhang, Kristl Pacheco, Fuqin Ma, Jianxin Zhang, Sophia Mundle, Yanhua Yan, Lucianna Barone, Christopher Rogers, Nicola Beltraminelli, Laurence Quemeneur, Harry Kleanthous, Stephen F. Anderson, Natalie G. Anosova

Publikováno v: The Journal of Immunology. 200:117.38-117.38

Clostridiumdifficile (C.difficile)is a significant human pathogen. C.difficile infection (CDI) causesclinical symptoms ranging from diarrhea to life-threatening fulminant pseudo membranous colitis. The pathogenesis of C. difficile is mediated by two

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a1e27e8f473df3d38a61d8eac7592bac
https://doi.org/10.4049/jimmunol.200.supp.117.38

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Preparation of pure, high titer, pseudoinfectious Flavivirus particles by hollow fiber tangential flow filtration and anion exchange chromatography

Autor: Harry Kleanthous, Sophia Mundle, Maryann Giel-Moloney, Stephen Anderson, Konstantin V. Pugachev

Publikováno v: Vaccine. 33(35)

Purification of enveloped viruses such as live flavivirus vaccine candidates poses a challenge as one must retain viral infectivity to preserve immunogenicity. Here we describe a laboratory-scale purification procedure for two replication defective (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81cb04f53e2788af9e98b8815b6b8477
https://pubmed.ncbi.nlm.nih.gov/25498209

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