Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Sophia Millington-Ward"'
Autor:
Arpad Palfi, Naomi Chadderton, Sophia Millington-Ward, Iris Post, Pete Humphries, Paul F. Kenna, G. Jane Farrar
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 25, Iss , Pp 236-249 (2022)
Recombinant adeno-associated virus (AAV) vectors are one of the main gene delivery vehicles used in retinal gene therapy approaches; however, there is a need to further improve the efficacy, tropism, and safety of these vectors. In this study, using
Externí odkaz:
https://doaj.org/article/71890c9910244be2891351755ac994bd
Autor:
Sophia Millington‐Ward, Naomi Chadderton, Laura K. Finnegan, Iris J.M. Post, Matthew Carrigan, Tom Gardiner, Elisa Peixoto, Daniel Maloney, Marian M. Humphries, Alan Stitt, Thierry Léveillard, Pete Humphries, Paul F. Kenna, Arpad Palfi, G. Jane Farrar
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 8, Pp n/a-n/a (2022)
Externí odkaz:
https://doaj.org/article/dd509cf8d833486f904bb413d8b73afb
Autor:
Naomi Chadderton, Arpad Palfi, Daniel M. Maloney, Matthew Carrigan, Laura K. Finnegan, Killian S. Hanlon, Ciara Shortall, Mary O’Reilly, Peter Humphries, Lorraine Cassidy, Paul F. Kenna, Sophia Millington-Ward, G. Jane Farrar
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 322 (2023)
AAV gene therapy for ocular disease has become a reality with the market authorisation of LuxturnaTM for RPE65-linked inherited retinal degenerations and many AAV gene therapies currently undergoing phase III clinical trials. Many ocular disorders ha
Externí odkaz:
https://doaj.org/article/bd632e8c331249f2b641b632703c689a
Autor:
Daniel M. Maloney, Naomi Chadderton, Sophia Millington-Ward, Arpad Palfi, Ciara Shortall, James J. O’Byrne, Lorraine Cassidy, David Keegan, Peter Humphries, Paul Kenna, Gwyneth Jane Farrar
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Optic Atrophy 1 (OPA1) is a mitochondrially targeted GTPase that plays a pivotal role in mitochondrial health, with mutations causing severe mitochondrial dysfunction and typically associated with Dominant Optic Atrophy (DOA), a progressive blinding
Externí odkaz:
https://doaj.org/article/4b299d0b315044cd94b2e4bfd9480a83
Autor:
Arpad Palfi, Adlet Yesmambetov, Sophia Millington-Ward, Ciara Shortall, Pete Humphries, Paul F. Kenna, Naomi Chadderton, G. Jane Farrar
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
With marketing approval of the first ocular gene therapy, and other gene therapies in clinical trial, treatments for inherited retinal degenerations (IRDs) have become a reality. Biallelic mutations in the tubby like protein 1 gene (TULP1) are causat
Externí odkaz:
https://doaj.org/article/a6f3077685d0445ca33f7f4aedb43e55
Autor:
Killian S. Hanlon, Naomi Chadderton, Arpad Palfi, Alfonso Blanco Fernandez, Peter Humphries, Paul F. Kenna, Sophia Millington-Ward, G. Jane Farrar
Publikováno v:
Frontiers in Neuroscience, Vol 11 (2017)
Significant advances in gene therapy have enabled exploration of therapies for inherited retinal disorders, many of which are in preclinical development or clinical evaluation. Gene therapy for retinal conditions has led the way in this growing field
Externí odkaz:
https://doaj.org/article/04cb834d403e47d8ba622955f1dd673d
Autor:
Arpad Palfi, Naomi Chadderton, Mary O'Reilly, Kerstin Nagel-Wolfrum, Uwe Wolfrum, Jean Bennett, Peter Humphries, Paul Kenna, Sophia Millington-Ward, Jane Farrar
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Externí odkaz:
https://doaj.org/article/f6fa74f399e04b7e8a9f988e52f52604
Autor:
Arpad Palfi, Naomi Chadderton, Mary O'Reilly, Kerstin Nagel-Wolfrum, Uwe Wolfrum, Jean Bennett, Peter Humphries, Paul Kenna, Sophia Millington-Ward, Jane Farrar
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 2, Iss , Pp - (2015)
As gene therapies for various forms of retinal degeneration progress toward human clinical trial, it will be essential to have a repertoire of safe and efficient vectors for gene delivery to the target cells. Recombinant adeno-associated virus (AAV)
Externí odkaz:
https://doaj.org/article/a385329107234f679f6928e877524be4
Autor:
Matthew Carrigan, Sophia Millington-Ward, Laura K. Finnegan, Peter Humphries, G. Jane Farrar, Megan Berkeley, Killian S. Hanlon, Naomi Chadderton, Paul F. Kenna, Arpad Palfi
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
Retinal ganglion cells (RGCs) are known to be involved in several ocular disorders, including glaucoma and Leber hereditary optic neuropathy (LHON), and hence represent target cells for gene therapies directed towards these diseases. Restricting gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04d350556f1f57cb4d5501926abf6cc
http://link.springer.com/article/10.1038/s41598-020-73257-z
http://link.springer.com/article/10.1038/s41598-020-73257-z
Autor:
Laura K. Finnegan, Naomi Chadderton, Paul F. Kenna, Arpad Palfi, Michael Carty, Andrew G. Bowie, Sophia Millington-Ward, G. Jane Farrar
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 3; Pages: 1606
International Journal of Molecular Sciences, Vol 23, Iss 1606, p 1606 (2022)
International Journal of Molecular Sciences, Vol 23, Iss 1606, p 1606 (2022)
The challenge of developing gene therapies for genetic forms of blindness is heightened by the heterogeneity of these conditions. However, mechanistic commonalities indicate key pathways that may be targeted in a gene-independent approach. Mitochondr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::735b4c2edf8e41ea75c59c7ec99d84f4