Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Sophia M. Sdao"'
Autor:
Hannah R Foster, Thuong Ho, Evgeniy Potapenko, Sophia M Sdao, Shih Ming Huang, Sophie L Lewandowski, Halena R VanDeusen, Shawn M Davidson, Rebecca L Cardone, Marc Prentki, Richard G Kibbey, Matthew J Merrins
Publikováno v:
eLife, Vol 11 (2022)
Pyruvate kinase (PK) and the phosphoenolpyruvate (PEP) cycle play key roles in nutrient-stimulated KATP channel closure and insulin secretion. To identify the PK isoforms involved, we generated mice lacking β-cell PKm1, PKm2, and mitochondrial PEP c
Externí odkaz:
https://doaj.org/article/fa152f2fa3f04b6c9965e3c25ec9218f
Autor:
Melissa T Adams, JaeAnn M Dwulet, Jennifer K Briggs, Christopher A Reissaus, Erli Jin, Joseph M Szulczewski, Melissa R Lyman, Sophia M Sdao, Vira Kravets, Sutichot D Nimkulrat, Suzanne M Ponik, Matthew J Merrins, Raghavendra G Mirmira, Amelia K Linnemann, Richard KP Benninger, Barak Blum
Publikováno v:
eLife, Vol 10 (2021)
The spatial architecture of the islets of Langerhans is hypothesized to facilitate synchronized insulin secretion among β cells, yet testing this in vivo in the intact pancreas is challenging. Robo βKO mice, in which the genes Robo1 and Robo2 are d
Externí odkaz:
https://doaj.org/article/6ffc13e7f9f7467bb80f8e6003960f0d
Autor:
Hannah R Foster, Thuong Ho, Evgeniy Potapenko, Sophia M Sdao, Shih Ming Huang, Sophie L Lewandowski, Halena R VanDeusen, Shawn M Davidson, Rebecca L Cardone, Marc Prentki, Richard G Kibbey, Matthew J Merrins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35c3bebc498a01f730e2d2247f52f9cc
https://doi.org/10.7554/elife.79422.sa2
https://doi.org/10.7554/elife.79422.sa2
Autor:
Hannah R. Foster, Thuong Ho, Evgeniy Potapenko, Sophia M. Sdao, Sophie L. Lewandowski, Halena R. VanDeusen, Shawn M. Davidson, Rebecca L. Cardone, Marc Prentki, Richard G. Kibbey, Matthew J. Merrins
SUMMARYPyruvate kinase (PK) and the phosphoenolpyruvate (PEP) cycle play key roles in nutrient-stimulated KATP channel closure and insulin secretion. To identify the PK isoforms involved, we generated mice lacking β-cell PKm1, PKm2, and mitochondria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19986653e36a89a26fb2c89d60b1a771
https://doi.org/10.1101/2022.02.09.478817
https://doi.org/10.1101/2022.02.09.478817
Autor:
Richard K.P. Benninger, Vira Kravets, Matthew J. Merrins, JaeAnn M. Dwulet, Suzanne M. Ponik, Jennifer K. Briggs, Christopher A. Reissaus, Melissa T. Adams, Joseph M. Szulczewski, Barak Blum, Sophia M. Sdao, Melissa R. Lyman, Raghavendra G. Mirmira, Erli Jin, Sutichot D. Nimkulrat, Amelia K. Linnemann
Publikováno v:
eLife, Vol 10 (2021)
The spatial architecture of the islets of Langerhans is hypothesized to facilitate synchronized insulin secretion among β cells, yet testing this in vivo in the intact pancreas is challenging. Robo βKO mice, in which the genes Robo1 and Robo2 are d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8bb7aaa2f3b7369c570eed12abf1b5b
https://doi.org/10.7554/elife.61308
https://doi.org/10.7554/elife.61308
Autor:
Richard G. Kibbey, Sophie L. Lewandowski, Hannah R. Foster, Halena R. VanDeusen, Sophia M. Sdao, Matthew J. Merrins, Rebecca L. Cardone, Thuong Ho, Evgeniy Potapenko
Publikováno v:
Diabetes. 70
Pancreatic β-cells couple nutrient metabolism with appropriate insulin secretion. Here, we examined the requirements of pyruvate kinase (PK) isoforms in fuel sensing through the β-cell specific deletion of consititutively active PKM1 and allosteric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f029964c42b2e0ab51e9b698bcc1d214
https://doi.org/10.2337/db21-127-or
https://doi.org/10.2337/db21-127-or
Publikováno v:
Diabetes. 70
Diabetes is characterized by a loss of functional β-cell mass. With current rodent models of chemically-induced diabetes such as streptozotocin, it is difficult to distinguish the consequence of β-cell loss from the decline in individual β-cell fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5db18bd6aeaa5000dea27951581a2181
https://doi.org/10.2337/db21-1254-p
https://doi.org/10.2337/db21-1254-p
Autor:
Jenny Tong, Sophia M. Sdao, Trillian Gregg, Jonathan E. Campbell, Jonathan D. Douros, Matthew J. Merrins, Jingjing Niu, David A. D'Alessio
Publikováno v:
Molecular Metabolism, Vol 28, Iss, Pp 144-150 (2019)
Molecular Metabolism
Molecular Metabolism
Objective Bariatric surgery acutely improves glucose control, an effect that is generally sustained for years in most patients. The acute postoperative glycemic reduction is at least partially mediated by enhanced incretin secretion and islet functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::662ff68f33e02621e89a890615b39f0c
https://doi.org/10.1016/j.molmet.2019.07.003
https://doi.org/10.1016/j.molmet.2019.07.003
Autor:
Matthew J. Merrins, Trillian Gregg, Jarred W. Rensvold, David J. Pagliarini, John M. Denu, Sophie L. Lewandowski, Rashpal S. Dhillon, Sophia M. Sdao
Publikováno v:
Journal of Biological Chemistry. 294:4656-4666
β-Cell mitochondria play a central role in coupling glucose metabolism with insulin secretion. Here, we identified a metabolic function of cyclin-dependent kinase 1 (CDK1)/cyclin B1—the activation of mitochondrial respiratory complex I—that is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19a471184894e7a3c477ba58edc4ec5b
https://doi.org/10.1074/jbc.ra118.006085
https://doi.org/10.1074/jbc.ra118.006085
Autor:
Melissa T Adams, JaeAnn M Dwulet, Jennifer K Briggs, Christopher A Reissaus, Erli Jin, Joseph M Szulczewski, Melissa R Lyman, Sophia M Sdao, Vira Kravets, Sutichot D Nimkulrat, Suzanne M Ponik, Matthew J Merrins, Raghavendra G Mirmira, Amelia K Linnemann, Richard KP Benninger, Barak Blum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15b144c21556aa9251af8562f1459b1a
https://doi.org/10.7554/elife.61308.sa2
https://doi.org/10.7554/elife.61308.sa2