Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Sophia M. Blake"'
Autor:
Axel Behrens, Martin Eilers, Nikita Popov, Richard Mitter, Sophia M. Blake, Atanu Chakraborty, Markus E. Diefenbacher
Legends for Supplementary Figures S1-S4.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82cfbc4b2047b90cb88e6296f11d2941
https://doi.org/10.1158/0008-5472.22406438.v1
https://doi.org/10.1158/0008-5472.22406438.v1
Autor:
Axel Behrens, Martin Eilers, Nikita Popov, Richard Mitter, Sophia M. Blake, Atanu Chakraborty, Markus E. Diefenbacher
The stability of several oncoproteins, including c-Myc, is regulated by ubiquitin-dependent degradation mediated by the SCF(Fbw7) ubiquitin ligase. This activity is antagonized by the deubiquitinase Usp28, which is highly expressed in murine and huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2f142e30006fb2efeb3296b9cb7d053
https://doi.org/10.1158/0008-5472.c.6507074
https://doi.org/10.1158/0008-5472.c.6507074
Autor:
Axel Behrens, Martin Eilers, Nikita Popov, Richard Mitter, Sophia M. Blake, Atanu Chakraborty, Markus E. Diefenbacher
Supplementary Methods and References. Description of additional methods and procedures used in the study. Also includes Supplementary References.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::201579e892103eff7f74c7f8e102f5e3
https://doi.org/10.1158/0008-5472.22406432
https://doi.org/10.1158/0008-5472.22406432
Autor:
Axel Behrens, Martin Eilers, Nikita Popov, Richard Mitter, Sophia M. Blake, Atanu Chakraborty, Markus E. Diefenbacher
Supplementary Figures S1-S4. Loss of Usp28 ameliorates the Fbw7 inactivation phenotype and partly restores cell differentiation in the intestine (S1); Deletion of Usp28 prolongs life expectancy and reduces tumor burden in the Fbw7-deleted APCmin/+ in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66c548cbe5cc3dca7ce1471c5a99a383
https://doi.org/10.1158/0008-5472.22406435.v1
https://doi.org/10.1158/0008-5472.22406435.v1
Autor:
Sophia M Blake, Stefan H Stricker, Hanna Halavach, Anna R Poetsch, George Cresswell, Gavin Kelly, Nnennaya Kanu, Silvia Marino, Nicholas M Luscombe, Steven M Pollard, Axel Behrens
Publikováno v:
eLife, Vol 5 (2016)
Glioblastoma multiforme (GBM) is the most aggressive human primary brain cancer. Using a Trp53-deficient mouse model of GBM, we show that genetic inactivation of the Atm cofactor Atmin, which is dispensable for embryonic and adult neural development,
Externí odkaz:
https://doaj.org/article/073bb96623004e5382578e901c23c945
Publikováno v:
PLoS Biology, Vol 11, Iss 6, p e1001586 (2013)
FBW7 is a crucial component of an SCF-type E3 ubiquitin ligase, which mediates degradation of an array of different target proteins. The Fbw7 locus comprises three different isoforms, each with its own promoter and each suspected to have a distinct s
Externí odkaz:
https://doaj.org/article/f5fb39c356274714acdaf7ed508dfa86
Autor:
Daniel Gerlach, Sabine Olt, Stefanie Schlager, Sophia M Blake, Anja Ebert, Manfred Koegl, Oliver Bergner, Johannes Wachter, Anna K. Traunbauer, Mark Pearson, Norbert Kraut, Johannes Zuber, Christoph Albrecht, Barbara Drobits, Norbert Schweifer, Martina Minnich, Vittoria Zinzalla, Francesca Trapani, Matthias Hinterndorfer, Tilman Voss, Julian Jude, Darryl B. McConnell, Carina Salomon
Publikováno v:
Oncotarget
Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphomas worldwide and is characterized by a high diversity of genetic and molecular alterations. Chromosomal translocations and mutations leading to deregulated expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e39bab60623b240ea21f21b00de8086
https://pubmed.ncbi.nlm.nih.gov/32180900
https://pubmed.ncbi.nlm.nih.gov/32180900
Autor:
Nikita Popov, Axel Behrens, Bradley Spencer-Dene, Markus E. Diefenbacher, Sophia M. Blake, Christina Schülein-Völk, Martin Eilers, Laura A. Jaenicke, Emma Nye
Publikováno v:
Journal of Clinical Investigation. 124:3407-3418
Colorectal cancer is the third most common cancer worldwide. Although the transcription factor c-MYC is misregulated in the majority of colorectal tumors, it is difficult to target directly. The deubiquitinase USP28 stabilizes oncogenic factors, incl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::740faca336aec7790f68e2c70cc44390
https://doi.org/10.1172/jci73733
https://doi.org/10.1172/jci73733
Autor:
Gavin Kelly, Steven M. Pollard, Nicholas M. Luscombe, Axel Behrens, Hanna Halavach, Anna R. Poetsch, Sophia M. Blake, Nnennaya Kanu, Silvia Marino, George D. Cresswell, Stefan H. Stricker
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4c2481f7b4a6b205354fe9689ccf675
https://doi.org/10.7554/elife.08711.043
https://doi.org/10.7554/elife.08711.043
Publikováno v:
Journal of Biological Chemistry. 285:4896-4908
ApoER2 and very low density lipoprotein (VLDL) receptor transmit the Reelin signal into target cells of the central nervous system. To a certain extent, both receptors can compensate for each other, and only the loss of both receptors results in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e48568ec54790ad536567f3ec4d3425
https://doi.org/10.1074/jbc.m109.025973
https://doi.org/10.1074/jbc.m109.025973