Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Sophia M Min"'
Autor:
David H. Drewry, Frances M. Potjewyd, Armin Bayati, Jeffery L. Smith, Rebekah J. Dickmander, Stefanie Howell, Sharon Taft-Benz, Sophia M. Min, Mohammad Anwar Hossain, Mark Heise, Peter S. McPherson, Nathaniel J. Moorman, Alison D. Axtman
Publikováno v:
Journal of Medicinal Chemistry. 65:12860-12882
From a designed library of indolyl pyrimidinamines, we identified a highly potent and cell-active chemical probe (17) that inhibits phosphatidylinositol-3-phosphate 5-kinase (PIKfyve). Comprehensive evaluation of inhibitor selectivity confirmed that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d43a4012ef9586e714a008decfeffd9
https://doi.org/10.1021/acs.jmedchem.2c00697
https://doi.org/10.1021/acs.jmedchem.2c00697
Autor:
Pei Zhou, Nimrat Chatterjee, Sophia M Min, Oliver Jonas, Graham C. Walker, Michael T. Hemann, Matthew G. Vander Heiden, Evan C. Lien, Matthew Whitman, Cynthia A. Harris, Alba Luengo, Jiyong Hong
Publikováno v:
Proc Natl Acad Sci U S A
REV1/POLζ-dependent mutagenic translesion synthesis (TLS) promotes cell survival after DNA damage but is responsible for most of the resulting mutations. A novel inhibitor of this pathway, JH-RE-06, promotes cisplatin efficacy in cancer cells and mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c7c722beb814c376f76b1eb101b6bda
https://doi.org/10.1073/pnas.2016064117
https://doi.org/10.1073/pnas.2016064117
Autor:
Hye Eun Lee, Yun Ge, Seung-Hwa Kwak, Sophia M Min, Hyunji Lee, Tesia N. Stephenson, Do-Yeon Kwon, You Mie Lee, Jea Hyun Kim, Jiyong Hong
Publikováno v:
Journal of medicinal chemistry. 63(13)
Tumors adapt to hypoxia by regulating angiogenesis, metastatic potential, and metabolism. These adaptations mediated by hypoxia-inducible factor 1 (HIF-1) make tumors more aggressive and resistant to chemotherapy and radiation. Therefore, HIF-1 is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ca5389f5944ce0d28fe88b8c0267a9
https://pubmed.ncbi.nlm.nih.gov/32579356
https://pubmed.ncbi.nlm.nih.gov/32579356