Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Sophia Lin"'
Autor:
Mohsen Saidinejad, Ashley A. Foster, Genevieve Santillanes, Joyce Li, Dina Wallin, Isabel A. Barata, Madeline Joseph, Emily Rose, Tabitha Cheng, Muhammad Waseem, Kathleen Berg, Gwendolyn Hooley, Timothy Ruttan, Sam Shahid, Samuel H. F. Lam, Siraj Amanullah, Sophia Lin, Melanie S. Heniff, Kathleen Brown, Marianne Gausche‐Hill, ACEP Pediatric Emergency Medicine Committee
Publikováno v:
Journal of the American College of Emergency Physicians Open, Vol 5, Iss 4, Pp n/a-n/a (2024)
Abstract Acute agitation in youth is a challenging presentation to the emergency department. In many cases, however, youth can be behaviorally de‐escalated using a combination of environmental modification and verbal de‐escalation. In cases where
Externí odkaz:
https://doaj.org/article/f048bf3ca7484e2eb05204b79d4cc356
Autor:
Angela Lackner, Julia Elise Cabral, Yanfei Qiu, Haitian Zhou, Lemuel Leonidas, Minh Anh Pham, Alijah Macapagal, Sophia Lin, Emy Armanus, Reginald McNulty
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110459- (2024)
Summary: Despite recent advances in the mechanism of oxidized DNA activating NLRP3, the molecular mechanism and consequence of oxidized DNA associating with NLRP3 remains unknown. Cytosolic NLRP3 binds oxidized DNA which has been released from the mi
Externí odkaz:
https://doaj.org/article/57484e7b371d4af28d52c9afcc4a5271
Autor:
Sophia Lin, Shen-En Chen, Wenwu Tang, Vidya Chavan, Navanit Shanmugam, Craig Allan, John Diemer
Publikováno v:
GeoHazards, Vol 5, Iss 1, Pp 286-309 (2024)
This research delves into the intricate dynamics of landslides, emphasizing their consequences on transportation infrastructure, specifically highways and roadway bridges in North Carolina. Based on a prior investigation of bridges in Puerto Rico aft
Externí odkaz:
https://doaj.org/article/7d157d6c76af4fdb8ac524e51cd82963
Autor:
Ludivine Lopez, Stephan De Waard, Hervé Meudal, Cécile Caumes, Kuldip Khakh, Steve Peigneur, Barbara Oliveira-Mendes, Sophia Lin, Jolien De Waele, Jérôme Montnach, Sandrine Cestèle, Agnès Tessier, J.P. Johnson, Massimo Mantegazza, Jan Tytgat, Charles Cohen, Rémy Béroud, Frank Bosmans, Céline Landon, Michel De Waard
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 165, Iss , Pp 115173- (2023)
Nav1.1 is an important pharmacological target as this voltage-gated sodium channel is involved in neurological and cardiac syndromes. Channel activators are actively sought to try to compensate for haploinsufficiency in several of these pathologies.
Externí odkaz:
https://doaj.org/article/00c037522f374110a6181eefd130b12d
Autor:
Jack Beetson, Pat Anderson, Sophia Lin, Frances Williamson, Rose Amazan, Bob Boughton, Stephen Morrell, Richard Taylor, Melanie Schwartz
Publikováno v:
International Journal for Crime, Justice and Social Democracy, Vol 11, Iss 4, Pp 56-68 (2022)
Using qualitative self-reported and observational evidence combined with a quantitative breakdown of linked administrative justice system data, this before-and-after study demonstrates the beneficial impacts of a First Nations community-controlled ad
Externí odkaz:
https://doaj.org/article/d898f434427a4d34a6a2537c9483003b
Publikováno v:
Frontiers in Public Health, Vol 11 (2023)
Externí odkaz:
https://doaj.org/article/ab2e5d7f67bd43178231fb13de7d468e
Publikováno v:
BMC Health Services Research, Vol 21, Iss 1, Pp 1-13 (2021)
Abstract Background Cervical cancer is the leading cancer among Ugandan women, contributing to 40 % of all cancer cases recorded in the cancer registry. Having identified the substantial impact of cervical cancer among Ugandan women, the Ministry of
Externí odkaz:
https://doaj.org/article/199ea5be8b184a249e8a4fa53ec65835
Autor:
Samrat Thouta, Matthew G. Waldbrook, Sophia Lin, Arjun Mahadevan, Janette Mezeyova, Maegan Soriano, Pareesa Versi, Samuel J. Goodchild, R. Ryley Parrish
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Voltage-gated sodium channels (Nav) are essential for the initiation and propagation of action potentials in neurons. Of the nine human channel subtypes, Nav1.1, Nav1.2 and Nav1.6 are prominently expressed in the adult central nervous system (CNS). A
Externí odkaz:
https://doaj.org/article/ec0db406855c4da79b69942688086629
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-15 (2021)
Abstract Background Cervical cancer is a leading cancer and cause of premature death among women in Uganda aged 15 to 44 years. To address the increasing burden of cervical cancer in Uganda, the Ministry of Health has adopted several strategies which
Externí odkaz:
https://doaj.org/article/a84686ccf64c47c89cc9cc6e1dc78e58
Autor:
JP Johnson, Thilo Focken, Kuldip Khakh, Parisa Karimi Tari, Celine Dube, Samuel J Goodchild, Jean-Christophe Andrez, Girish Bankar, David Bogucki, Kristen Burford, Elaine Chang, Sultan Chowdhury, Richard Dean, Gina de Boer, Shannon Decker, Christoph Dehnhardt, Mandy Feng, Wei Gong, Michael Grimwood, Abid Hasan, Angela Hussainkhel, Qi Jia, Stephanie Lee, Jenny Li, Sophia Lin, Andrea Lindgren, Verner Lofstrand, Janette Mezeyova, Rostam Namdari, Karen Nelkenbrecher, Noah Gregory Shuart, Luis Sojo, Shaoyi Sun, Matthew Taron, Matthew Waldbrook, Diana Weeratunge, Steven Wesolowski, Aaron Williams, Michael Wilson, Zhiwei Xie, Rhena Yoo, Clint Young, Alla Zenova, Wei Zhang, Alison J Cutts, Robin P Sherrington, Simon N Pimstone, Raymond Winquist, Charles J Cohen, James R Empfield
Publikováno v:
eLife, Vol 11 (2022)
NBI-921352 (formerly XEN901) is a novel sodium channel inhibitor designed to specifically target NaV1.6 channels. Such a molecule provides a precision-medicine approach to target SCN8A-related epilepsy syndromes (SCN8A-RES), where gain-of-function (G
Externí odkaz:
https://doaj.org/article/ff1c4ccf767e411f85c1b12a0db8fe55