Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Sophia Lai"'
Autor:
Donghyun Lim, Qingxuan Zhou, Kurt J. Cox, Benjamin K. Law, Miseon Lee, Praveen Kokkonda, Vedagopuram Sreekanth, Rajaiah Pergu, Santosh K. Chaudhary, Soumyashree A. Gangopadhyay, Basudeb Maji, Sophia Lai, Yuka Amako, David B. Thompson, Hari K. K. Subramanian, Michael F. Mesleh, Vlado Dančík, Paul A. Clemons, Bridget K. Wagner, Christina M. Woo, George M. Church, Amit Choudhary
Publikováno v:
Nat Cell Biol
The need to control the activity and fidelity of CRISPR-associated nucleases has resulted in a demand for inhibitory anti-CRISPR molecules. The small-molecule inhibitor discovery platforms available at present are not generalizable to multiple nuclea
Publikováno v:
Protein Homeostasis in Drug Discovery. :419-446
Publikováno v:
The Journal of Alternative and Complementary Medicine. 27:796-802
Objective: To characterize dietary supplements marketed online as “ephedra-containing or ephedra-like products” for weight management and to assess labeling/marketing compliance with the ban on the...
Publikováno v:
Cell Chemical Biology. 28:1081-1089
Nature takes advantage of induced proximity to perform various functions. Taking inspiration from nature, we can also trigger desired biological processes using bifunctional small molecules that artificially induce proximity. For example, bifunctiona
Autor:
Max Jan, David R. Liu, Arghya Deb, Vedagopuram Sreekanth, Praveen Kokkonda, Veronika Shoba, Santosh K. Chaudhary, Benjamin L. Ebert, Jaron A. M. Mercer, Praveen K. Tiwari, Amit Choudhary, Sophia Lai, Tuan M. Nguyen
Proteolysis Targeting Chimeras (PROTACs), a class of heterobifunctional molecules that recruit target proteins to E3 ligases, have gained traction for targeted protein degradation. However, pomalidomide, a widely used E3 ligase recruiter in PROTACs,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af392a53b6a8e1f2ea031a468ca70edc
https://doi.org/10.1101/2021.11.18.468552
https://doi.org/10.1101/2021.11.18.468552
Publikováno v:
Journal of alternative and complementary medicine (New York, N.Y.). 27(9)
Autor:
Stuart L. Schreiber, Veronika Shoba, Peng Wu, Sachini U. Siriwardena, Mengchao Shi, Sophia Lai, Dhanushka N P Munkanatta Godage, Santosh K. Chaudhary, Amit Choudhary
Publikováno v:
Journal of the American Chemical Society. 142(33)
Small molecules have been classically developed to inhibit enzyme activity; however, new classes of small molecules that endow new functions to enzymes via proximity-mediated effect are emerging. Phosphorylation (native or neo) of any given protein-o
Publikováno v:
International Journal of Clinical Pharmacy. 39:831-835
Background According to drug interaction databases, torsemide may potentiate the effects of warfarin. Evidence for this drug-drug interaction, however, is conflicting and the clinical significance is unknown. Objective The aim of this study is to eva
Autor:
Bence Szaszkó, Rebecca Rosa Schmid, Ulrich Pomper, Mira Maiworm, Sophia Laiber, Hannah Tschenett, Urs Markus Nater, Ulrich Ansorge
Publikováno v:
Acta Psychologica, Vol 241, Iss , Pp 104075- (2023)
Engaging in yoga may mitigate stress and anxiety in individuals while potentially enhancing one's capacity to manage distractions. Our research aimed to explore the relation between these two outcomes: Can an eight-week yoga program foster distractio
Externí odkaz:
https://doaj.org/article/ed82fa61be8244adb78cbb894cc0c2fb
Autor:
Michael Naguib, Yury Gogotsi, M. Parans Paranthaman, Matthew Rager, Tomonori Saito, Meng-Qiang Zhao, Sophia Lai, Tolga Aytug
Publikováno v:
RSC Advances. 6:72069-72073
Herein we report on the synthesis and characterization of MXene–polyacrylamide (PAM) nanocomposite films. Dimethylsulfoxide intercalation in-between the Ti3C2-based MXene layers led to full delamination of the MXene layers and hence a uniform dispe