Towards early diagnosis of Alzheimer’s disease: advances in immune-related blood biomarkers and computational approaches

Autor: Sophia Krix, Ella Wilczynski, Neus Falgàs, Raquel Sánchez-Valle, Eti Yoles, Uri Nevo, Kuti Baruch, Holger Fröhlich

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

Alzheimer’s disease has an increasing prevalence in the population world-wide, yet current diagnostic methods based on recommended biomarkers are only available in specialized clinics. Due to these circumstances, Alzheimer’s disease is usually di

Externí odkaz: https://doaj.org/article/91321161073d4696b5cf39759c3346f6

MultiGML: Multimodal Graph Machine Learning for Prediction of Adverse Drug Events

Autor: Sophia Krix, Lauren Nicole DeLong, Sumit Madan, Daniel Domingo-Fernández, Ashar Ahmad, Sheraz Gul, Andrea Zaliani, Holger Fröhlich

SummaryAdverse drug events constitute a major challenge for the success of clinical trials. Several computational strategies have been suggested to estimate the risk of adverse drug events in preclinical drug development. While these approaches have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d72375abd1f5594f3cbfccdcc3b99a99
https://doi.org/10.1101/2022.12.16.520738

Automated in vivo drug screen in zebrafish identifies synapse-stabilising drugs with relevance to spinal muscular atrophy

Autor: Thomas Becker, Thomas H. Gillingwater, Helena Chaytow, Catherina G. Becker, Neil O. Carragher, Hannah L. Smith, Ana-Maria Oprişoreanu, Sophia Krix

Publikováno v: Disease Models & Mechanisms
article-version (VoR) Version of Record
Oprişoreanu, A, Smith, H L, Krix, S, Chaytow, H, Carragher, N O, Gillingwater, T H, Becker, C G & Becker, T 2021, ' Automated in vivo drug screen in zebrafish identifies synapse-stabilising drugs with relevance to spinal muscular atrophy ', Disease Models and Mechanisms, vol. 14, no. 4 . https://doi.org/10.1242/dmm.047761

Synapses are particularly vulnerable in many neurodegenerative diseases and often the first to degenerate, for example in the motor neuron disease spinal muscular atrophy (SMA). Compounds that can counteract synaptic destabilisation are rare. Here, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f807cdc973f970ca813a85171f02205a
https://pubmed.ncbi.nlm.nih.gov/33973627