Výsledky vyhledávání - "Sophia Krause"

Prediction of Unbound Fractions for in Vitro–in Vivo Extrapolation of Biotransformation Data

Autor: Sophia Krause, Kai-Uwe Goss

Publikováno v: Chemical Research in Toxicology. 34:7-11

For in vitro-in vivo extrapolation of biotransformation data, the different sorptive environments in vitro and in vivo need to be considered. The most common approach for doing so is using the ratio of unbound fractions in vitro and in vivo. In the l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::888e428b061635890f5038b00a917cfc
https://doi.org/10.1021/acs.chemrestox.0c00349

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Could chemical exposure and bioconcentration in fish be affected by slow binding kinetics in blood?

Autor: Kai-Uwe Goss, Sophia Krause

Publikováno v: Environmental Science: Processes & Impacts. 23:714-722

The possible implications of slow binding kinetics on respiratory uptake, bioconcentration and exposure of chemicals were evaluated in the present study. Most physiological and chemical information needed for such an evaluation is already known from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::496e1ca0cb2d91c93e71f06580b32044
https://doi.org/10.1039/d1em00056j

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