Výsledky vyhledávání - "Sophia J, Wiedemann"

Akademický článek

Prohormone convertase 1/3 deficiency causes obesity due to impaired proinsulin processing

Autor: Daniel T. Meier, Leila Rachid, Sophia J. Wiedemann, Shuyang Traub, Kelly Trimigliozzi, Marc Stawiski, Loïc Sauteur, Denise V. Winter, Christelle Le Foll, Catherine Brégère, Raphael Guzman, Alex Odermatt, Marianne Böni-Schnetzler, Marc Y. Donath

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)

Defective insulin secretion is observed early in the development of diabetes. Here the authors report that β cell-specific deficiency of the insulin prohormone convertase 1/3 (PC1/3) leads not only to hyperglycemia, but also to hyperphagic obesity i

Externí odkaz: https://doaj.org/article/c2d52d524de146cb95b1f820a6251d26

Zobrazit plný text záznamu

Akademický článek

Targeting colonic macrophages improves glycemic control in high-fat diet-induced obesity

Publikováno v: Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)

Expansion of pro-inflammatory macrophages in the colon occurs early after high-fat diet initiation, prior to macrophage accumulation in the adipose tissue, in a microbiome-dependent fashion. Macrophage depletion systemically and/or exclusively in the

Externí odkaz: https://doaj.org/article/80b59b6deb3e496981cc210ada5bc2b9

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

IL-1beta promotes the age-associated decline of beta cell function

Autor: Marianne Böni-Schnetzler, Hélène Méreau, Leila Rachid, Sophia J. Wiedemann, Friederike Schulze, Kelly Trimigliozzi, Daniel T. Meier, Marc Y. Donath

Publikováno v: iScience, Vol 24, Iss 11, Pp 103250- (2021)

Summary: Aging is the prime risk factor for the development of type 2 diabetes. We investigated the role of the interleukin-1 (IL-1) system on insulin secretion in aged mice. During aging, expression of the protective IL-1 receptor antagonist decreas

Externí odkaz: https://doaj.org/article/8c210037d7104ffebcadf66383ce7f6c

Zobrazit plný text záznamu

Akademický článek

Distinct Transcriptional Responses across Tissue-Resident Macrophages to Short-Term and Long-Term Metabolic Challenge

Autor: Urszula Brykczynska, Marco Geigges, Sophia J. Wiedemann, Erez Dror, Marianne Böni-Schnetzler, Christoph Hess, Marc Y. Donath, Renato Paro

Publikováno v: Cell Reports, Vol 30, Iss 5, Pp 1627-1643.e7 (2020)

Summary: The innate immune system safeguards the organism from both pathogenic and environmental stressors. Also, physiologic levels of nutrients affect organismal and intra-cellular metabolism and challenge the immune system. In the long term, over-

Externí odkaz: https://doaj.org/article/54b0b70065bb4546aa8d688de4a57702

Zobrazit plný text záznamu

Markers of systemic inflammation in response to osmotic stimulus in healthy volunteers

Autor: Ingeborg Schnyder, Mirjam Christ-Crain, Wiebke Fenske, Sophia J. Wiedemann, Konrad Strauss, Clara O Sailer

Publikováno v: Endocrine Connections, Vol 8, Iss 9, Pp 1282-1287 (2019)
Endocrine Connections

Osmotic stimulus or stress results in vasopressin release. Animal and human in vitro studies have shown that inflammatory parameters, such as interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α), increase in parallel in the central nervous syst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b1b61ad80ec29f4e2f946bec7a89f65
https://ec.bioscientifica.com/view/journals/ec/8/9/EC-19-0280.xml

Zobrazit plný text záznamu

1955-P: Interleukin-1ß Orchestrates Non–Glucose Dependent Cephalic Phase Insulin Release in Health and Obesity

Autor: Kelly Trimigliozzi, Marianne Boeni-Schnetzler, Daniel T. Meier, Erez Dror, Sophia J. Wiedemann, Theresa V. Rohm, Friederike Schulze, Jose Alberto Molina-Tijeras, Hélène Méreau, Marc Y. Donath, Leila Rachid, Christophe Magnan, Stéphanie P. Häuselmann

Publikováno v: Diabetes. 69

The non-glucose dependent spike in insulin levels immediately following the beginning of a meal is called the cephalic or pre-absorptive phase of insulin secretion. Even though this early insulin response is of marked consequence for overall postpran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f29f4b09a705f7f2cf34e9e868da550
https://doi.org/10.2337/db20-1955-p

Zobrazit plný text záznamu

Inhibition of IL-1beta improves Glycaemia in a Mouse Model for Gestational Diabetes

Autor: Friederike, Schulze, Josua, Wehner, Denise V, Kratschmar, Valmir, Makshana, Daniel T, Meier, Stéphanie P, Häuselmann, Elise, Dalmas, Constanze, Thienel, Erez, Dror, Sophia J, Wiedemann, Shuyang, Traub, Thierry M, Nordmann, Leila, Rachid, Axel, De Baat, Theresa V, Rohm, Cheng, Zhao, Alex, Odermatt, Marianne, Böni-Schnetzler, Marc Y, Donath

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports

Gestational diabetes mellitus (GDM) is one of the most common diseases associated with pregnancy, however, the underlying mechanisms remain unclear. Based on the well documented role of inflammation in type 2 diabetes, the aim was to investigate the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::976405532cde1a3d3d9ec6e2c0b3848a

Zobrazit plný text záznamu

IL-1beta promotes the age-associated decline of beta cell function

Autor: Marc Y. Donath, Friederike Schulze, Sophia J. Wiedemann, Kelly Trimigliozzi, Leila Rachid, Marianne Böni-Schnetzler, Hélène Méreau, Daniel T. Meier

Publikováno v: iScience, Vol 24, Iss 11, Pp 103250-(2021)
iScience

Summary Aging is the prime risk factor for the development of type 2 diabetes. We investigated the role of the interleukin-1 (IL-1) system on insulin secretion in aged mice. During aging, expression of the protective IL-1 receptor antagonist decrease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c99d439df2d0bca61b9a84165d6d79e2
https://doi.org/10.1016/j.isci.2021.103250

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání