Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Sophia J, Wiedemann"'
Autor:
Daniel T. Meier, Leila Rachid, Sophia J. Wiedemann, Shuyang Traub, Kelly Trimigliozzi, Marc Stawiski, Loïc Sauteur, Denise V. Winter, Christelle Le Foll, Catherine Brégère, Raphael Guzman, Alex Odermatt, Marianne Böni-Schnetzler, Marc Y. Donath
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Defective insulin secretion is observed early in the development of diabetes. Here the authors report that β cell-specific deficiency of the insulin prohormone convertase 1/3 (PC1/3) leads not only to hyperglycemia, but also to hyperphagic obesity i
Externí odkaz:
https://doaj.org/article/c2d52d524de146cb95b1f820a6251d26
Autor:
Theresa V. Rohm, Lena Keller, Angela J. T. Bosch, Shefaa AlAsfoor, Zora Baumann, Amandine Thomas, Sophia J. Wiedemann, Laura Steiger, Elise Dalmas, Josua Wehner, Leila Rachid, Catherine Mooser, Bahtiyar Yilmaz, Nerea Fernandez Trigo, Annaise J. Jauch, Stephan Wueest, Daniel Konrad, Sandrine Henri, Jan H. Niess, Petr Hruz, Stephanie C. Ganal-Vonarburg, Julien Roux, Daniel T. Meier, Claudia Cavelti-Weder
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
Expansion of pro-inflammatory macrophages in the colon occurs early after high-fat diet initiation, prior to macrophage accumulation in the adipose tissue, in a microbiome-dependent fashion. Macrophage depletion systemically and/or exclusively in the
Externí odkaz:
https://doaj.org/article/80b59b6deb3e496981cc210ada5bc2b9
Autor:
Marianne Böni-Schnetzler, Hélène Méreau, Leila Rachid, Sophia J. Wiedemann, Friederike Schulze, Kelly Trimigliozzi, Daniel T. Meier, Marc Y. Donath
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103250- (2021)
Summary: Aging is the prime risk factor for the development of type 2 diabetes. We investigated the role of the interleukin-1 (IL-1) system on insulin secretion in aged mice. During aging, expression of the protective IL-1 receptor antagonist decreas
Externí odkaz:
https://doaj.org/article/8c210037d7104ffebcadf66383ce7f6c
Autor:
Urszula Brykczynska, Marco Geigges, Sophia J. Wiedemann, Erez Dror, Marianne Böni-Schnetzler, Christoph Hess, Marc Y. Donath, Renato Paro
Publikováno v:
Cell Reports, Vol 30, Iss 5, Pp 1627-1643.e7 (2020)
Summary: The innate immune system safeguards the organism from both pathogenic and environmental stressors. Also, physiologic levels of nutrients affect organismal and intra-cellular metabolism and challenge the immune system. In the long term, over-
Externí odkaz:
https://doaj.org/article/54b0b70065bb4546aa8d688de4a57702
Autor:
Erez Dror, Marc Y. Donath, Hélène Méreau, Friederike Schulze, Kelly Trimigliozzi, Stéphanie P. Häuselmann, Marianne Böni-Schnetzler, Daniel T. Meier, Marc Stawiski, Leila Rachid, Jose Alberto Molina-Tijeras, Sophia J. Wiedemann, Christelle Le Foll, Christophe Magnan
The initial cephalic phase of insulin secretion is mediated through the vagus nerve and is not due to glycemic stimulation of pancreatic β-cells. Recently, IL-1β was shown to stimulate postprandial insulin secretion. Here, we describe that this inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb406ec06f7a686f45298c77bee55f2
https://www.zora.uzh.ch/id/eprint/211022/
https://www.zora.uzh.ch/id/eprint/211022/
Autor:
Ingeborg Schnyder, Mirjam Christ-Crain, Wiebke Fenske, Sophia J. Wiedemann, Konrad Strauss, Clara O Sailer
Publikováno v:
Endocrine Connections, Vol 8, Iss 9, Pp 1282-1287 (2019)
Endocrine Connections
Endocrine Connections
Osmotic stimulus or stress results in vasopressin release. Animal and human in vitro studies have shown that inflammatory parameters, such as interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α), increase in parallel in the central nervous syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b1b61ad80ec29f4e2f946bec7a89f65
https://ec.bioscientifica.com/view/journals/ec/8/9/EC-19-0280.xml
https://ec.bioscientifica.com/view/journals/ec/8/9/EC-19-0280.xml
Autor:
Kelly Trimigliozzi, Marianne Boeni-Schnetzler, Daniel T. Meier, Erez Dror, Sophia J. Wiedemann, Theresa V. Rohm, Friederike Schulze, Jose Alberto Molina-Tijeras, Hélène Méreau, Marc Y. Donath, Leila Rachid, Christophe Magnan, Stéphanie P. Häuselmann
Publikováno v:
Diabetes. 69
The non-glucose dependent spike in insulin levels immediately following the beginning of a meal is called the cephalic or pre-absorptive phase of insulin secretion. Even though this early insulin response is of marked consequence for overall postpran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f29f4b09a705f7f2cf34e9e868da550
https://doi.org/10.2337/db20-1955-p
https://doi.org/10.2337/db20-1955-p
Autor:
Friederike, Schulze, Josua, Wehner, Denise V, Kratschmar, Valmir, Makshana, Daniel T, Meier, Stéphanie P, Häuselmann, Elise, Dalmas, Constanze, Thienel, Erez, Dror, Sophia J, Wiedemann, Shuyang, Traub, Thierry M, Nordmann, Leila, Rachid, Axel, De Baat, Theresa V, Rohm, Cheng, Zhao, Alex, Odermatt, Marianne, Böni-Schnetzler, Marc Y, Donath
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Gestational diabetes mellitus (GDM) is one of the most common diseases associated with pregnancy, however, the underlying mechanisms remain unclear. Based on the well documented role of inflammation in type 2 diabetes, the aim was to investigate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::976405532cde1a3d3d9ec6e2c0b3848a
Autor:
Marc Y. Donath, Friederike Schulze, Sophia J. Wiedemann, Kelly Trimigliozzi, Leila Rachid, Marianne Böni-Schnetzler, Hélène Méreau, Daniel T. Meier
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103250-(2021)
iScience
iScience
Summary Aging is the prime risk factor for the development of type 2 diabetes. We investigated the role of the interleukin-1 (IL-1) system on insulin secretion in aged mice. During aging, expression of the protective IL-1 receptor antagonist decrease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c99d439df2d0bca61b9a84165d6d79e2
https://doi.org/10.1016/j.isci.2021.103250
https://doi.org/10.1016/j.isci.2021.103250
Autor:
Beckey Trinh, Marc Y. Donath, Marianne Böni-Schnetzler, Benjamin Schelker, Matthias Hepprich, Sophia J. Wiedemann
Publikováno v:
Diabetes. 68
Background: Postprandial hypoglycemia (PPH) is a debilitating complication after bariatric surgery, due to an exaggerated hyperinsulinemic response after carbohydrate ingestion. Recent studies have shown that IL-1β contributes to the postprandial st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1aa5bcb90ab9a50380de7acfb526b5d8
https://doi.org/10.2337/db19-1830-p
https://doi.org/10.2337/db19-1830-p