Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Sophia H. Le"'
Autor:
Benjamin P. Song, Michelle F. Ragsac, Krissie Tellez, Granton A. Jindal, Jessica L. Grudzien, Sophia H. Le, Emma K. Farley
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112052- (2023)
Summary: The notochord is a defining feature of all chordates. The transcription factors Zic and ETS regulate enhancer activity within the notochord. We conduct high-throughput screens of genomic elements within developing Ciona embryos to understand
Externí odkaz:
https://doaj.org/article/0a07ee4646954a249ff52c80c196b956
Autor:
Granton A Jindal, Alexis T Bantle, Joe J Solvason, Jessica L Grudzien, Agnieszka D’Antonio-Chronowska, Fabian Lim, Sophia H Le, Reid O Larsen, Adam Klie, Kelly A Frazer, Emma K Farley
SummaryEnhancers direct precise gene expression patterns during development and harbor the majority of variants associated with disease. We find that suboptimal affinity ETS transcription factor binding sites are prevalent within Ciona and human deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c28fdfda915bfaeb65ad5eb7faf659e1
https://doi.org/10.1101/2022.05.27.493636
https://doi.org/10.1101/2022.05.27.493636
SummaryAn emerging regulatory principle governing enhancers is the use of suboptimal affinity binding sites to encode tissue-specific gene expression. Here we investigate if optimizing single-nucleotide variants that violate this principle can disrup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16d3128782325b0fae7031059b7a26c6
https://doi.org/10.1101/2022.05.27.493789
https://doi.org/10.1101/2022.05.27.493789