Molecular and functional profiling identifies therapeutically targetable vulnerabilities in plasmablastic lymphoma

Autor: Fabian Frontzek, Annette M. Staiger, Myroslav Zapukhlyak, Wendan Xu, Irina Bonzheim, Vanessa Borgmann, Philip Sander, Maria Joao Baptista, Jan-Niklas Heming, Philipp Berning, Ramona Wullenkord, Tabea Erdmann, Mathias Lutz, Pia Veratti, Sophia Ehrenfeld, Kirsty Wienand, Heike Horn, John R. Goodlad, Matthew R. Wilson, Ioannis Anagnostopoulos, Mario Lamping, Eva Gonzalez-Barca, Fina Climent, Antonio Salar, Josep Castellvi, Pau Abrisqueta, Javier Menarguez, Teresa Aldamiz, Julia Richter, Wolfram Klapper, Alexandar Tzankov, Stefan Dirnhofer, Andreas Rosenwald, José Luis Mate, Gustavo Tapia, Peter Lenz, Cornelius Miething, Wolfgang Hartmann, Björn Chapuy, Falko Fend, German Ott, José-Tomas Navarro, Michael Grau, Georg Lenz

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Plasmablastic lymphoma (PBL) is an aggressive lymphoma subtype characterized by poor prognosis but the molecular knowledge of the disease is limited. Here, the authors perform whole exome sequencing and copy number determination of primary samples hi

Externí odkaz: https://doaj.org/article/6d054d5ed82e4409b9428afb7baa476b

A novel conditional NPM-ALK-driven model of CD30+ T-cell lymphoma mediated by a translational stop cassette

Autor: Cathrin Klingeberg, Sophia Ehrenfeld, Anna Lena Illert, Martina Rudelius, Cornelius Miething, Dietmar Pfeifer, Nicolas Schneider, Pia Veratti, Falko Fend, Justus Duyster, Teresa Poggio, Robin Khan, Desiree M. Redhaber, Stefanie Kreutmair, Khalid Shoumariyeh, Leticia Quintanilla-Martinez

Publikováno v: Oncogene. 39:1904-1913

Targeted expression of transgenes is essential for the accurate representation of human disease in in vivo models. Current approaches to generate conditional transgenic mouse models are cumbersome and not amenable to high-throughput analysis since th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aca1aa6d954324367266923f9042cc64
https://doi.org/10.1038/s41388-019-1058-1

Molecular and functional profiling identifies therapeutically targetable vulnerabilities in plasmablastic lymphoma

Autor: Michael Grau, Kirsty Wienand, Pia Veratti, Gustavo Tapia, Tabea Erdmann, Eva González-Barca, Falko Fend, Jan-Niklas Heming, Björn Chapuy, Irina Bonzheim, Sophia Ehrenfeld, Alexandar Tzankov, Javier Menárguez, Mathias Lutz, Philip Sander, Matthew R. Wilson, José-Tomás Navarro, Julia Richter, Wolfram Klapper, Stefan Dirnhofer, Cornelius Miething, Pau Abrisqueta, Andreas Rosenwald, Fina Climent, Ioannis Anagnostopoulos, Mario Lamping, Wendan Xu, Annette M. Staiger, Georg Lenz, Myroslav Zapukhlyak, Philipp Berning, Vanessa Borgmann, Wolfgang Hartmann, Peter Lenz, Teresa Aldamiz, Fabian Frontzek, German Ott, Maria Joao Baptista, Josep Castellví, Antonio Salar, Jose Luis Mate, Heike Horn, John R. Goodlad, Ramona Wullenkord

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Nature Communications
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Scientia
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Plasmablastic lymphoma (PBL) represents a rare and aggressive lymphoma subtype frequently associated with immunosuppression. Clinically, patients with PBL are characterized by poor outcome. The current understanding of the molecular pathogenesis is l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bd88233e6b47877ca5d45e25f3a08e7
http://hdl.handle.net/2445/180256

Towards Improved Models of NPM-ALK Induced T-Cell Lymphoma

Autor: Robin Khan, Cathrin Klingeberg, Justus Duyster, Cornelius Miething, Khalid Shoumariyeh, Sophia Ehrenfeld, Stefanie Kreutmair, Anna Lena Illert, Desiree Melanie Redhaber, Teresa Poggio

Publikováno v: Blood. 132:1342-1342

Time- and tissue-specific expression of transgenes is essential for the accurate representation of human disease in in vivo models. To improve flexibility but also fidelity of ALK+ ALCL models, we developed new approaches enabling lineage specific ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::714390cbe754c669bea0eff643bcf2ad
https://doi.org/10.1182/blood-2018-99-115872

Activation loop phosphorylation regulates B-Raf in vivo and transformation by B-Raf mutants

Autor: Franziska M. Uhl, Sandra Braun, Lisa C. Schmitt, Robert Zeiser, Björn Schorch, Martin Köhler, Wolfgang W. A. Schamel, Michael Röring, Katharina Heilmann, Sebastian Herzog, Florian Weinberg, Gina J. Fiala, Thorsten Kaltenbacher, Hassan Jumaa, Sophia Ehrenfeld, Natalie Stickel, Tilman Brummer

Publikováno v: The EMBO journal. 35(2)

Despite being mutated in cancer and RASopathies, the role of the activation segment (AS) has not been addressed for B-Raf signaling in vivo. Here, we generated a conditional knock-in mouse allowing the expression of the B-Raf(AVKA) mutant in which th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17eed5bae953f396386651384c44ceb6
https://pubmed.ncbi.nlm.nih.gov/26671982