Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sophia DeLuca"'
Autor:
Hung X. Nguyen, Tianyu Wu, Daniel Needs, Hengtao Zhang, Robin M. Perelli, Sophia DeLuca, Rachel Yang, Michael Pan, Andrew P. Landstrom, Craig Henriquez, Nenad Bursac
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/f565703737de4d078598a60ba6a31e7c
Autor:
Hung X. Nguyen, Tianyu Wu, Daniel Needs, Hengtao Zhang, Robin M. Perelli, Sophia DeLuca, Rachel Yang, Michael Pan, Andrew P. Landstrom, Craig Henriquez, Nenad Bursac
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Abstract Therapies for cardiac arrhythmias could greatly benefit from approaches to enhance electrical excitability and action potential conduction in the heart by stably overexpressing mammalian voltage-gated sodium channels. However, the large size
Externí odkaz:
https://doaj.org/article/e4a62bc25c4744e394d6e8b834aeeb8e
Autor:
Andrew M. Vekstein, David C. Wendell, Sophia DeLuca, Ruorong Yan, Yifan Chen, Muath Bishawi, Garth W. Devlin, Aravind Asokan, Kenneth D. Poss, Dawn E. Bowles, Adam R. Williams, Nenad Bursac
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
BackgroundThe optimal delivery route to enhance effectiveness of regenerative therapeutics to the human heart is poorly understood. Direct intra-myocardial (IM) injection is the gold standard, however, it is relatively invasive. We thus compared targ
Externí odkaz:
https://doaj.org/article/993f14381787463495862d3ca7622ee7
Autor:
Nicholas Strash, Sophia DeLuca, Geovanni L Janer Carattini, Soon Chul Heo, Ryne Gorsuch, Nenad Bursac
Publikováno v:
eLife, Vol 10 (2021)
Multiple mitogenic pathways capable of promoting mammalian cardiomyocyte (CM) proliferation have been identified as potential candidates for functional heart repair following myocardial infarction. However, it is unclear whether the effects of these
Externí odkaz:
https://doaj.org/article/8e568113f8e14154bb83f868392d1564
Autor:
Archan Chakraborty, Nora G. Peterson, Juliet S. King, Ryan T. Gross, Michelle Mendiola Pla, Aatish Thennavan, Kevin C. Zhou, Sophia DeLuca, Nenad Bursac, Dawn E. Bowles, Matthew J. Wolf, Donald T. Fox
Publikováno v:
bioRxiv
SUMMARYDevelopmentally programmed polyploidy (whole-genome-duplication) of cardiomyocytes is common across evolution. Functions of such polyploidy are essentially unknown. Here, we reveal roles for precise polyploidy levels in cardiac tissue. We high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92896fde057234d266b1c5ce0d45b42a
https://europepmc.org/articles/PMC9934670/
https://europepmc.org/articles/PMC9934670/
Autor:
Nicholas Strash, Sophia DeLuca, Geovanni L. Janer Carattini, Yifan Chen, Jacob Scherba, Mehul Jain, Ramona Naseri, Tianyu Wu, Nenad Bursac
Mitogens capable of promoting cardiomyocyte proliferation represent important targets for functional heart regeneration following myocardial infarction. We previously described an ERK-dependent pro-proliferative tissue phenotype following overexpress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::683f7501635e3b8b830e5be0ac760ff8
https://doi.org/10.1101/2022.02.28.482357
https://doi.org/10.1101/2022.02.28.482357
Autor:
Ruorong Yan, Valentina Cigliola, Kelsey A. Oonk, Zachary Petrover, Sophia DeLuca, David W. Wolfson, Andrew Vekstein, Michelle A. Mendiola, Garth Devlin, Muath Bishawi, Matthew P. Gemberling, Tanvi Sinha, Michelle A. Sargent, Allen J. York, Avraham Shakked, Paige DeBenedittis, David C. Wendell, Jianhong Ou, Junsu Kang, Joseph A. Goldman, Gurpreet S. Baht, Ravi Karra, Adam R. Williams, Dawn E. Bowles, Aravind Asokan, Eldad Tzahor, Charles A. Gersbach, Jeffery D. Molkentin, Nenad Bursac, Brian L. Black, Kenneth D. Poss
Publikováno v:
Cell stem cell. 30(1)
The efficacy and safety of gene-therapy strategies for indications like tissue damage hinge on precision; yet, current methods afford little spatial or temporal control of payload delivery. Here, we find that tissue-regeneration enhancer elements (TR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efb309f70b6db494883207d10bf992c7
https://pubmed.ncbi.nlm.nih.gov/36516837
https://pubmed.ncbi.nlm.nih.gov/36516837
Autor:
Andrew M Vekstein, David C Wendell, Dawn E Bowles, Sophia DeLuca, Ruorong Yan, Muath Bishawi, Garth Devlin, Aravind Asokan, Kenneth D Poss, Nenad Bursac, Adam R Williams
Publikováno v:
Circulation. 144
Introduction: The optimal cardiac delivery route for stem cell and gene therapeutics is poorly understood. Direct intramyocardial (IM) injection has been proposed as the gold standard, however, it is invasive and not studied in detail against targete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd8a1a9d34c24be4addf193f35e14e0d
https://doi.org/10.1161/circ.144.suppl_1.12181
https://doi.org/10.1161/circ.144.suppl_1.12181
Autor:
Nenad Bursac, Nicholas Strash, Sophia DeLuca, Geovanni L Janer Carattini, Soon Chul Heo, Ryne Gorsuch
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Multiple mitogenic pathways capable of promoting mammalian cardiomyocyte (CM) proliferation have been identified as potential candidates for functional heart repair following myocardial infarction. However, it is unclear whether the effects of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::396cccc3a355ad2aa4f247d490350a6e
https://doi.org/10.1101/2020.12.15.422603
https://doi.org/10.1101/2020.12.15.422603