Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Sophia Davidson"'
Autor:
Simon P. Preston, Cody C. Allison, Jan Schaefer, William Clow, Stefanie M. Bader, Sophie Collard, Wasan O. Forsyth, Michelle P. Clark, Alexandra L. Garnham, Connie S. N. Li-Wai-Suen, Thanushi Peiris, Jack Teale, Liana Mackiewicz, Sophia Davidson, Marcel Doerflinger, Marc Pellegrini
Publikováno v:
Cell Death and Disease, Vol 14, Iss 2, Pp 1-10 (2023)
Abstract Necroptosis is a lytic and inflammatory form of cell death that is highly constrained to mitigate detrimental collateral tissue damage and impaired immunity. These constraints make it difficult to define the relevance of necroptosis in disea
Externí odkaz:
https://doaj.org/article/92ba881eb0be4a2499528d1347c1f20d
Autor:
Annemarie Steiner, Katja Hrovat-Schaale, Ignazia Prigione, Chien-Hsiung Yu, Pawat Laohamonthonkul, Cassandra R. Harapas, Ronnie Ren Jie Low, Dominic De Nardo, Laura F. Dagley, Michael J. Mlodzianoski, Kelly L. Rogers, Thomas Zillinger, Gunther Hartmann, Michael P. Gantier, Marco Gattorno, Matthias Geyer, Stefano Volpi, Sophia Davidson, Seth L. Masters
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Mutations in the coatomer complex I can result in endoplasmic reticulum stress and inflammatory consequences. Here authors define aberrant activation of the STING immunosensing pathway in a disturbed coatmer complex context and the therapeutic modula
Externí odkaz:
https://doaj.org/article/30fa6bbd687e41a1bd2b9d85bd46d601
Autor:
Akul Singhania, Christine M. Graham, Leona Gabryšová, Lúcia Moreira-Teixeira, Evangelos Stavropoulos, Jonathan M. Pitt, Probir Chakravarty, Annika Warnatsch, William J. Branchett, Laura Conejero, Jing-Wen Lin, Sophia Davidson, Mark S. Wilson, Gregory Bancroft, Jean Langhorne, Eva Frickel, Abdul K. Sesay, Simon L. Priestnall, Eleanor Herbert, Marianna Ioannou, Qian Wang, Ian R. Humphreys, Jonathan Dodd, Peter J. M. Openshaw, Katrin D. Mayer-Barber, Dragana Jankovic, Alan Sher, Clare M. Lloyd, Nicole Baldwin, Damien Chaussabel, Venizelos Papayannopoulos, Andreas Wack, Jacques F. Banchereau, Virginia M. Pascual, Anne O’Garra
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-21 (2019)
The authors present an extensive profile of host transcriptional respones to a diverse group of pathogens and allergens. In doing so, they identify TH1, type I IFN, TH17, and TH2 responses, that underlie each immune response in both the blood and lun
Externí odkaz:
https://doaj.org/article/2de9148c41624ebdb261719be7a52d90
Autor:
Nikaïa Smith, Nicolas Pietrancosta, Sophia Davidson, Jacques Dutrieux, Lise Chauveau, Pasquale Cutolo, Michel Dy, Daniel Scott-Algara, Bénédicte Manoury, Onofrio Zirafi, Isabelle McCort-Tranchepain, Thierry Durroux, Françoise Bachelerie, Olivier Schwartz, Jan Münch, Andreas Wack, Sébastien Nisole, Jean-Philippe Herbeuval
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Plasmacytoid dendritic cells produce type I interferons in response to viral sensing. Here the authors show that amines inhibit these plasmacytoid dendritic cell responses through CXCR4 engagement.
Externí odkaz:
https://doaj.org/article/4dcfeb35184e41db9075187f20ab2655
Autor:
Konrad C. Bradley, Katja Finsterbusch, Daniel Schnepf, Stefania Crotta, Miriam Llorian, Sophia Davidson, Serge Y. Fuchs, Peter Staeheli, Andreas Wack
Publikováno v:
Cell Reports, Vol 28, Iss 1, Pp 245-256.e4 (2019)
Summary: Type I interferon (IFNα/β) pathways are fine-tuned to elicit antiviral protection while minimizing immunopathology; however, the initiating stimuli, target tissues, and underlying mechanisms are unclear. Using models of physiological and d
Externí odkaz:
https://doaj.org/article/b38812bc603440c1ac47e05b4631b8c3
Autor:
Sophia Davidson, Teresa M McCabe, Stefania Crotta, Hans Henrik Gad, Edith M Hessel, Soren Beinke, Rune Hartmann, Andreas Wack
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 9, Pp 1099-1112 (2016)
Abstract Influenza A virus (IAV)‐induced severe disease is characterized by infected lung epithelia, robust inflammatory responses and acute lung injury. Since type I interferon (IFNαβ) and type III interferon (IFNλ) are potent antiviral cytokin
Externí odkaz:
https://doaj.org/article/29e9a7e829bc409682faf9a9dbdbb308
Autor:
Sophia Davidson
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Influenza viruses (IVs) are a continual threat to global health. The high mutation rate of the IV genome makes this virus incredibly successful, genetic drift allows for annual epidemics which result in thousands of deaths and millions of hospitaliza
Externí odkaz:
https://doaj.org/article/de7f973ad8004c0f9077e505b4e64ee8
Autor:
Rohit G. Saldanha, Katherine R. Balka, Sophia Davidson, Brynn K. Wainstein, Melanie Wong, Rebecca Macintosh, Christine K. C. Loo, Martin A. Weber, Vasanth Kamath, CIRCA, AADRY, Fiona Moghaddas, Dominic De Nardo, Paul Edgar Gray, Seth Lucian Masters
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
BackgroundMutations in the gene encoding stimulator of interferon genes (STING) underlie a type I interferon (IFN) associated disease, STING-associated vasculopathy with onset in infancy (SAVI). Patients suffer cutaneous vasculopathy and interstitial
Externí odkaz:
https://doaj.org/article/3461fbb1b9274e5bb9138468e379ff03
Autor:
Cassandra R. Harapas, Kim S. Robinson, Kenneth Lay, Jasmine Wong, Ricardo Moreno Traspas, Nasrin Nabavizadeh, Annick Rass-Rothschild, Bertrand Boisson, Scott B. Drutman, Pawat Laohamonthonkul, Devon Bonner, Jingwei Rachel Xiong, Mark D. Gorrell, Sophia Davidson, Chien-Hsiung Yu, Mark D. Fleming, Jonas Gudera, Jerry Stein, Miriam Ben-Harosh, Emily Groopman, Akiko Shimamura, Hannah Tamary, Hülya Kayserili, Nevin Hatipoğlu, Jean-Laurent Casanova, Jonathan A. Bernstein, Franklin L. Zhong, Seth L. Masters, Bruno Reversade
Publikováno v:
Sci Immunol
Dipeptidyl peptidase 9 (DPP9) is a direct inhibitor of NLRP1, but how it affects inflammasome regulation in vivo is not yet established. Here, we report three families with immune-associated defects, poor growth, pancytopenia, and skin pigmentation a
Autor:
Sophia Davidson, Chien-Hsiung Yu, Annemarie Steiner, Frédéric Ebstein, Paul J. Baker, Valentina Jarur-Chamy, Katja Hrovat Schaale, Pawat Laohamonthonkul, Klara Kong, Dale J. Calleja, Cassandra R. Harapas, Katherine R. Balka, Jacob Mitchell, Jacob T. Jackson, Niall D. Geoghegan, Fiona Moghaddas, Kelly L. Rogers, Katrin D. Mayer-Barber, Adriana A. De Jesus, Dominic De Nardo, Benjamin T. Kile, Anthony J. Sadler, M. Cecilia Poli, Elke Krüger, Raphaela Goldbach Mansky, Seth L. Masters
Publikováno v:
Science Immunology. 7
Proteasome dysfunction can lead to autoinflammatory disease associated with elevated type I interferon (IFN-αβ) and NF-κB signaling; however, the innate immune pathway driving this is currently unknown. Here, we identified protein kinase R (PKR) a