Výsledky vyhledávání - "Sophia C. Carroll"

Enhancing the Dissolution Stability of Hard Gelatin Capsules Using Activated Carbon as a Packaging Component

Autor: Bruce C. MacDonald, M. D. Likar, Gail M. Johnson, Sophia C. Carroll, Thean Yeoh, Stephen T. Colgan, J. Sean Space

Publikováno v: Journal of pharmaceutical sciences. 107(12)

Hard gelatin capsule (HGC) shells are widely used to encapsulate drugs for oral delivery but are vulnerable to gelatin cross-linking, which can lead to slower and more variable in vitro dissolution rates. Adding proteolytic enzymes to the dissolution

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9378c92c9a1954db4ce0d668197587cb
https://pubmed.ncbi.nlm.nih.gov/30145210

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Use of Activated Carbon in Packaging to Attenuate Formaldehyde-Induced and Formic Acid-Induced Degradation and Reduce Gelatin Cross-Linking in Solid Dosage Forms

Autor: Gail M. Johnson, Sophia C. Carroll, Bruce C. MacDonald, M. D. Likar, James F. Jensen, Vincent DeMatteo, Todd Zelesky, Joel M. Hawkins, J. Sean Space, Stephen T. Colgan, Raymond Chen

Publikováno v: Journal of pharmaceutical sciences. 105(7)

Formaldehyde and formic acid are reactive impurities found in commonly used excipients and can be responsible for limiting drug product shelf-life. Described here is the use of activated carbon in drug product packaging to attenuate formaldehyde-indu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58870dc45cb4c8999c8546127b837f3f
https://pubmed.ncbi.nlm.nih.gov/27262203

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