Výsledky vyhledávání - "Sophia Bylsma"

Akademický článek

Germline DNA damage response gene mutations as predictive biomarkers of immune checkpoint inhibitor efficacy

Autor: Michael J. Dennis, Sophia Bylsma, Lisa Madlensky, Meghana S. Pagadala, Hannah Carter, Sandip P. Patel

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

BackgroundImpaired DNA damage response (DDR) can affect immune checkpoint inhibitors (ICI) efficacy and lead to heightened immune activation. We assessed the impact of pathogenic or likely pathogenic (P/LP) germline DDR mutations on ICI response and

Externí odkaz: https://doaj.org/article/1e0413811b3145389253abec7216b286

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67 Germline mutations in DNA damage response and repair genes are associated with increased clinical benefit from immune checkpoint inhibitors

Autor: Michael Dennis, Sophia Bylsma, Lisa Madlensky, Sandip Patel

Publikováno v: Regular and Young Investigator Award Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fa9bc8e0f002d4e6124a813f29f8d2ce
https://doi.org/10.1136/jitc-2022-sitc2022.0067

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Immune Checkpoint Inhibitor Rechallenge After Prior Immune Toxicity

Autor: Sophia Bylsma, Karen Yun, Sandip Patel, Michael J Dennis

Publikováno v: Current treatment options in oncology, vol 23, iss 9

Opinion statementImmune checkpoint inhibitors (ICIs) have become an essential part of treatment for many cancer types. These monoclonal antibodies remove a critical negative regulatory signal that allows the immune system to recognize and destroy mal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::858ff178a16456bc0597b1de4fb4e970
https://escholarship.org/uc/item/27h0d8c1

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