Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Sophia Bustraan"'
Autor:
Michael E. Pacold, Lewis C. Cantley, Matthias Mann, Eva Hernando, Matthew G. Vander Heiden, Michael A. Davies, Kayvan R. Keshari, Rakesh K. Jain, Jean J. Zhao, Min Yu, Drew R. Jones, David M. Sabatini, Mark Manfredi, Adam Friedman, Vipin Suri, Nello Mainolfi, John H. Healey, Paolo Cotzia, Matija Snuderl, Samuel F. Bakhoum, Benjamin D. Stein, Roshan K. Sriram, Sarah Bacha, Edward R. Kastenhuber, Vinagolu K. Rajasekhar, Ariana Plasger, Jing Ni, Diane S. Kang, Roozbeh Eskandari, Grant M. Fischer, Gino B. Ferraro, Ahmed Ali, Shawn M. Davidson, Alba Luengo, Roger J. Liang, Sophia Bustraan, Sophia Doll, Victoria Osorio-Vasquez, Eugenie Kim, Bryan Ngo
Supplementary Figures and a Supplementary Table
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eda6631052d9083df40c06605fff1966
https://doi.org/10.1158/2159-8290.22536382
https://doi.org/10.1158/2159-8290.22536382
Autor:
Michael E. Pacold, Lewis C. Cantley, Matthias Mann, Eva Hernando, Matthew G. Vander Heiden, Michael A. Davies, Kayvan R. Keshari, Rakesh K. Jain, Jean J. Zhao, Min Yu, Drew R. Jones, David M. Sabatini, Mark Manfredi, Adam Friedman, Vipin Suri, Nello Mainolfi, John H. Healey, Paolo Cotzia, Matija Snuderl, Samuel F. Bakhoum, Benjamin D. Stein, Roshan K. Sriram, Sarah Bacha, Edward R. Kastenhuber, Vinagolu K. Rajasekhar, Ariana Plasger, Jing Ni, Diane S. Kang, Roozbeh Eskandari, Grant M. Fischer, Gino B. Ferraro, Ahmed Ali, Shawn M. Davidson, Alba Luengo, Roger J. Liang, Sophia Bustraan, Sophia Doll, Victoria Osorio-Vasquez, Eugenie Kim, Bryan Ngo
A hallmark of metastasis is the adaptation of tumor cells to new environments. Metabolic constraints imposed by the serine and glycine–limited brain environment restrict metastatic tumor growth. How brain metastases overcome these growth-prohibitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::582a473e89b095f751a52c1fc41c9747
https://doi.org/10.1158/2159-8290.c.6548131.v1
https://doi.org/10.1158/2159-8290.c.6548131.v1
Autor:
Edward R. Kastenhuber, John H. Healey, Lewis C. Cantley, Michael E. Pacold, Paolo Cotzia, Diane Kang, Min Yu, Mark Manfredi, Gino B. Ferraro, Nello Mainolfi, Benjamin D. Stein, Rakesh K. Jain, Matija Snuderl, Roozbeh Eskandari, Alba Luengo, Sophia Doll, Eugenie Kim, Shawn M. Davidson, Roshan K. Sriram, Kayvan R. Keshari, Vipin Suri, Bryan Ngo, David M. Sabatini, Sarah Bacha, Jing Ni, Michael A. Davies, Samuel F. Bakhoum, Roger Liang, Eva Hernando, Ahmed Ali, Ariana Plasger, Victoria Osorio-Vasquez, Drew R. Jones, Matthias Mann, Jean J. Zhao, Vinagolu K. Rajasekhar, Matthew G. Vander Heiden, Sophia Bustraan, Adam Friedman, Grant M. Fischer
Publikováno v:
Cancer Discov
PMC
PMC
A hallmark of metastasis is the adaptation of tumor cells to new environments. Metabolic constraints imposed by the serine and glycine–limited brain environment restrict metastatic tumor growth. How brain metastases overcome these growth-prohibitiv
Autor:
Lewis C. Cantley, Roozbeh Eskandari, Vipin Suri, Roger Liang, Nello Mainolfi, Edward R. Kastenhuber, Diane Kang, Min Yu, Matthew G. Vander Heiden, Ariana Plasger, Jing Ni, Alba Luengo, Victoria Osorio-Vasquez, Ahmed Ali, Rakesh K. Jain, David M. Sabatini, Edouard Mullarky, Eugenie Kim, Shawn M. Davidson, Samuel F. Bakhoum, Matija Snuderl, Bryan Ngo, Eva Hernando, Sophia Doll, Jean J. Zhao, Mark Manfredi, Matthias Mann, Sarah Bacha, Michael E. Pacold, Roshan K. Siriam, Gino D. Ferraro, Paolo Cotzia, Sophia Bustraan, Adam Friedman, Drew R. Jones
A hallmark of metastasis is the adaptation of tumor cells to new environments. Although it is well established that the metabolic milieu of the brain is severely deprived of nutrients, particularly the amino acids serine and its catabolite glycine, h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e114c3b878bf679b40fc5a4320aca66
https://doi.org/10.1101/2020.03.03.974980
https://doi.org/10.1101/2020.03.03.974980
Autor:
Samuel F. Bakhoum, Rakesh K. Jain, Matija Snuderl, Vinagolu K. Rajasekhar, Ariana Plasger, Victoria Osorio-Vasquez, Michael Davies, Gino B. Ferraro, Roozbeh Eskandari, Sophia Bustraan, Lewis C. Cantley, Michael E. Pacold, Ahmed Ali, Bryan Ngo, Eugenie Kim, Grant M. Fischer, Shawn M. Davidson, Paolo Cotzia, Min Yu, Sophia Doll, Matthew G. Vander Heiden, Sarah Bacha, David M. Sabatini, Eva Hernando, Edward R. Kastenhuber, Roger Liang, Roshan K. Sriram, John H. Healey, Drew R. Jones, Alba Luengo, Kayvan R. Keshari, Matthias Mann, Jean J. Zhao
Publikováno v:
Neuro-oncology Advances
The brain environment is low in amino acids, including serine and glycine, both of which are important for tumor growth as they are precursors of proteins and nucleotide bases. How tumor cells overcome these conditions to proliferate and survive in t
Autor:
Jing Ni, Roozbeh Eskandari, Matija Snuderl, Edward R. Kastenhuber, Sophia Doll, Roshan K. Sriram, Rakesh K. Jain, Jean J. Zhao, Sophia Bustraan, Michael E. Pacold, Ahmed Ali, Eugenie Kim, Samuel F. Bakhoum, Edouard Mullarky, Bryan Ngo, Adam Friedman, Nello Mainolfi, Matthias Mann, Drew R. Jones, David M. Sabatini, Vipin Suri, Ariana Plasger, Roger Liang, Shawn M. Davidson, Lewis C. Cantley, Diane Kang, Min Yu, Alba Luengo, Benjamin D. Stein, Sarah Bacha, Mark Manfredi, Gino D. Ferraro, Matthew G. Vander Heiden
Publikováno v:
Cancer Research. 80:5712-5712
The metabolic milieu of the brain is severely deprived of nutrients, including the amino acids serine and its catabolite glycine. The metabolic rewiring required for tumor cells to survive in the nutrient-limited environment of the brain and the meta
Autor:
Marc R. Mansour, Nadine Farah, Teodora Popa, Sunniyat Rahman, Rachel J. Mitchell, Richard A. Young, Rosemary E. Gale, Christopher Allen, Sophia Bustraan, David C. Linch, Arnold Pizzey, Michael Magnussen, Frank J. T. Staal, Tom Naughton, Brian J. Abraham, Karin Pike-Overzet, Laura Garcia-Perez, Zhaodong Li, Krisztina Zuborne Alapi, A. Thomas Look, Theresa E. Leon, Adele K. Fielding
Publikováno v:
Blood, 129(24), 3221-3226
Prof. Young
Prof. Young
Somatic mutations within noncoding genomic regions that aberrantly activate oncogenes have remained poorly characterized. Here we describe recurrent activating intronic mutations of LMO2, a prominent oncogene in T-cell acute lymphoblastic leukemia (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::974dc70bbf3a822f4cc2f9610040c273
http://hdl.handle.net/1887/116028
http://hdl.handle.net/1887/116028
Autor:
Glenda J, Dickson, Sophia, Bustraan, Robert K, Hills, Akbar, Ali, Anthony H, Goldstone, Alan K, Burnett, David C, Linch, Rosemary E, Gale
Publikováno v:
British Journal of Haematology
Summary Older adult patients (≥60 years) with acute myeloid leukaemia (AML) are generally considered to be poor‐risk and there is limited information available regarding risk stratification based on molecular characterization in this age group, p
Autor:
Krisztina Zuborne Alapi, Tom Naughton, Theresa E. Leon, Brian J. Abraham, Christopher Allen, Michael Magnussen, Zhaodong Li, Richard A. Young, Rosemary E. Gale, Adele K. Fielding, A. Thomas Look, Nadine Farah, Sunniyat Rahman, Marc R. Mansour, Sophia Bustraan, David C. Linch, Arnold Pizzey, Rachel J. Mitchell
Publikováno v:
Blood. 128:733-733
LMO2is a crucial regulator of normal hematopoiesis but is progressively silenced from the early T-cell progenitor stage of thymic development. Aberrant LMO2 expression leads to a block in differentiation, increased self-renewal and aggressive T-cell