Výsledky vyhledávání - "Sophia Allaf Shahin"

Akademický článek

Chick chorioallantoic membrane assay as an in vivo model to study the effect of nanoparticle-based anticancer drugs in ovarian cancer

Autor: Binh Thanh Vu, Sophia Allaf Shahin, Jonas Croissant, Yevhen Fatieiev, Kotaro Matsumoto, Tan Le-Hoang Doan, Tammy Yik, Shirleen Simargi, Altagracia Conteras, Laura Ratliff, Chiara Mauriello Jimenez, Laurence Raehm, Niveen Khashab, Jean-Olivier Durand, Carlotta Glackin, Fuyuhiko Tamanoi

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)

Abstract New therapy development is critically needed for ovarian cancer. We used the chicken egg CAM assay to evaluate efficacy of anticancer drug delivery using recently developed biodegradable PMO (periodic mesoporous organosilica) nanoparticles.

Externí odkaz: https://doaj.org/article/849a54837dce44fab69e9ca907705965

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Hyaluronic acid conjugated nanoparticle delivery of siRNA against TWIST reduces tumor burden and enhances sensitivity to cisplatin in ovarian cancer

Autor: Altagracia Contreras, Carlotta A. Glackin, Shirleen I. Simargi, Juli Unternaehrer, Ruining Wang, Fuyuhiko Tamanoi, Wei Wen, Sophia Allaf Shahin, Liliana Parra Echavarria, Thanh H. Dellinger, Louise Qu, Jeffrey I. Zink

Publikováno v: Nanomedicine: Nanotechnology, Biology and Medicine. 14:1381-1394

TWIST protein is critical to development and is activated in many cancers. TWIST regulates epithelial-mesenchymal transition, and is linked to angiogenesis, metastasis, cancer stem cell phenotype, and drug resistance. The majority of epithelial ovari

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::349f1703e9f24f233bd8956672a18fb5
https://doi.org/10.1016/j.nano.2018.04.008

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Chick chorioallantoic membrane assay as an in vivo model to study the effect of nanoparticle-based anticancer drugs in ovarian cancer

Autor: Jonas G. Croissant, Altagracia Conteras, Laurence Raehm, Tammy Yik, Kotaro Matsumoto, Fuyuhiko Tamanoi, Niveen M. Khashab, Laura E. Ratliff, Tan Le Hoang Doan, Carlotta A. Glackin, Yevhen Fatieiev, Shirleen I. Simargi, Chiara Mauriello Jimenez, Sophia Allaf Shahin, Binh Thanh Vu, Jean-Olivier Durand

Publikováno v: Scientific reports, vol 8, iss 1
Scientific Reports
Scientific Reports, Nature Publishing Group, 2018, 8 (1), pp.8524. 〈10.1038/s41598-018-25573-8〉
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports, Nature Publishing Group, 2018, 8 (1), pp.8524. ⟨10.1038/s41598-018-25573-8⟩

New therapy development is critically needed for ovarian cancer. We used the chicken egg CAM assay to evaluate efficacy of anticancer drug delivery using recently developed biodegradable PMO (periodic mesoporous organosilica) nanoparticles. Human ova

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::199644e63fd98353d1ae43b8569835e7
https://escholarship.org/uc/item/5m17k78n

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Mesoporous core-shell silica nanoparticles with anti-fouling properties for ovarian cancer therapy

Autor: Carlotta A. Glackin, María Vallet-Regí, Sandra Sánchez-Salcedo, Sophia Allaf Shahin, Jeffrey I. Zink

Publikováno v: E-Prints Complutense. Archivo Institucional de la UCM
instname
E-Prints Complutense: Archivo Institucional de la UCM
Universidad Complutense de Madrid
Chemical Engineering Journal

Mesoporous silica nanoparticles (MSNPs) have many potential applications in biomedical fields. However, when MSNPs are exposed to plasma, protein adsorption leads to opsonization and decreases blood circulation time. A new multifunctional nanodevice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebaf2afe2f399b877fcf626634c9cdd3

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Nanoparticle delivery of siRNA against TWIST to reduce drug resistance and tumor growth in ovarian cancer models

Autor: James Finlay, Thanh H. Dellinger, Carlotta A. Glackin, Wei Wen, Fuyuhiko Tamanoi, Jeffrey I. Zink, Ruining Wang, Juyao Dong, Cai M. Roberts, Sophia Allaf Shahin

Publikováno v: Nanomedicine : nanotechnology, biology, and medicine, vol 13, iss 3
Nanomedicine

Epithelial ovarian cancer (EOC) is the most deadly gynecologic malignancy on account of its late stage at diagnosis and frequency of drug resistant recurrences. Novel therapies to overcome these barriers are urgently needed. TWIST is a developmental

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8edfbf7dd0144a73eda02ef41050d053
https://escholarship.org/uc/item/6mj02610

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Disruption of TWIST1-RELA binding by mutation and competitive inhibition to validate the TWIST1 WR domain as a therapeutic target

Autor: Carlotta A. Glackin, Thanh H. Dellinger, John C. Williams, Cai M. Roberts, Sophia Allaf Shahin, Joana Loeza

Publikováno v: BMC Cancer

Background Most cancer deaths result from tumor cells that have metastasized beyond their tissue of origin, or have developed drug resistance. Across many cancer types, patients with advanced stage disease would benefit from a novel therapy preventin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6500cd5011f2e366ed208b180bd87d6a
https://doi.org/10.1186/s12885-017-3169-9

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Abstract 2152: Optimizing therapies for drug-resistant ovarian cancer stem cells using aCAM-PDX model

Autor: Ruining Wang, Laura E. Ratliff, Carlotta A. Glackin, Sophia Allaf Shahin, Fuyuhiko Tamanoi, Shirleen I. Simargi, Jeffrey I. Zink, Thanh H. Dellinger, Altagracia Contreras, Binh Vu, Julia Unternaehrer-Hamm

Publikováno v: Cancer Research. 78:2152-2152

Purpose: To develop rapidly operational CAM-PDX (chorioallantoic membrane-patient derived xenograft) tumor models that morphologically resemble human tumors in order to perform therapeutic/efficacy studies targeting TWIST, a transcription factor expr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7c89b207bc269734343e4e2f335eae8a
https://doi.org/10.1158/1538-7445.am2018-2152

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Abstract A42: TWIST1 as a driver of accelerated tumor growth and drug resistance: Potential novel pathways and therapeutics

Autor: Sophia Allaf Shahin, Emily Ye, Leslie Cisneros, Joana Loeza, Thanh H. Dellinger, James Finlay, Michelle A. Tran, Carlotta A. Glackin, Cai Roberts

Publikováno v: Clinical Cancer Research. 22:A42-A42

Introduction: Epithelial ovarian cancer (EOC) is particularly deadly due to its fast rate of growth, dissemination, and chemoresistant recurrences. Novel therapies are urgently needed to limit metastasis and restore platinum sensitivity. We have inve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e57837430ef02c195c2d0d752d4ed97
https://doi.org/10.1158/1557-3265.ovca15-a42

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