Výsledky vyhledávání - "Sophia Akbareian"

Visual Overview from Systemic Ablation of MMP-9 Triggers Invasive Growth and Metastasis of Pancreatic Cancer via Deregulation of IL6 Expression in the Bone Marrow

Autor: Achim Krüger, Ghislain Opdenakker, Dylan R. Edwards, Percy Knolle, Susanne Schaten, Sophia Akbareian, Sonja Berchtold, Annique Hunger, Kaarin Ahomaa, Michael Gerg, Jennifer Vandooren, Barbara Grünwald

Visual Overview

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4789626ae01198b1dc81dc46d691efed
https://doi.org/10.1158/1541-7786.22513762.v1

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Supplementary Figure S2 from Systemic Ablation of MMP-9 Triggers Invasive Growth and Metastasis of Pancreatic Cancer via Deregulation of IL6 Expression in the Bone Marrow

Knock-down of MMP-9 did not promote invasive growth of Panc02 pancreatic cancer cells in vitro.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a95463ccd4b826c28c7e52b95e08ca9b
https://doi.org/10.1158/1541-7786.22513765.v1

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Supplementary Figure Legends from Systemic Ablation of MMP-9 Triggers Invasive Growth and Metastasis of Pancreatic Cancer via Deregulation of IL6 Expression in the Bone Marrow

Supplementary Figure Legends

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f5b4ded48e1b6b4bfad49ccf15be324
https://doi.org/10.1158/1541-7786.22513774

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Conformation-specific inhibitory anti-MMP-7 monoclonal antibody sensitizes pancreatic ductal adenocarcinoma cells to chemotherapeutic cell kill

Autor: Barbara Grünwald, Sophia Akbareian, Achim Krüger, Irit Sagi, Vishnu Mohan, Maxim Levin, David P. Kelsen, Miriam Eisenstein, Orly Dym, Inna Solomonov, Kenneth H. Yu, Jean P. Gaffney, Mordehay Klepfish, Dylan R. Edwards

Publikováno v: Cancers
Volume 13
Issue 7
Cancers, Vol 13, Iss 1679, p 1679 (2021)

Simple Summary Extracellular matrix remodeling enzymes are dysregulated in several pathologies. Our aim was to generate a unique function blocking monoclonal antibody against one such cancer-associated enzyme, matrix metalloproteinase 7 (MMP-7). We g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6782ac3c635430c1d5b48d69b18bf12

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ADAMTS-1 and Syndecan-4 intersect in the regulation of cell migration and angiogenesis

Autor: Abdullah A. A. Alghamdi, Jordi Lambert, Robert T. Johnson, Stephen D. Robinson, Kate A Makin, Sophia Akbareian, Dylan R. Edwards

Publikováno v: Journal of Cell Science
article-version (VoR) Version of Record

ADAMTS-1 is an extracellular protease with critical roles in organogenesis and angiogenesis. Here we demonstrate a functional convergence of ADAMTS-1 and the transmembrane heparan sulfate proteoglycan syndecan-4 in influencing adhesion, migration and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10817e551072d5647b8910b4cd5478cf
https://ueaeprints.uea.ac.uk/id/eprint/74327/

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ADAMTS-1 and Syndecan-4 intersect in the regulation of cell migration and angiogenesis

Autor: Dylan R. Edwards, Stephen D. Robinson, Kate A Makin, Robert T. Johnson, Jordi Lambert, Sophia Akbareian

The extracellular proteoglycanase ADAMTS-1 has critical roles in organogenesis and angiogenesis. We demonstrate here the functional convergence of ADAMTS-1 and the transmembrane heparan sulfate proteoglycan syndecan-4 in influencing adhesion, migrati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f136d0a19d8086239160027aafa98f38

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Systemic Ablation of MMP-9 Triggers Invasive Growth and Metastasis of Pancreatic Cancer via Deregulation of IL6 Expression in the Bone Marrow

Autor: Dylan R. Edwards, Sonja Berchtold, Barbara Grünwald, Annique Hunger, Ghislain Opdenakker, Percy A. Knolle, Susanne Schaten, Kaarin Ahomaa, Michael Gerg, Jennifer Vandooren, Sophia Akbareian, Achim Krüger

Publikováno v: Molecular Cancer Research. 14:1147-1158

Matrix metalloproteinase 9 (MMP-9/Gelatinase B) is overexpressed in pancreatic ductal adenocarcinoma (PDAC) and plays a central role in tumor cell invasion and metastasis. Here we complemented mechanistic insights in the cancer biology of MMP-9 and i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a47bca64b4329a4016e18245283a31f8
https://doi.org/10.1158/1541-7786.mcr-16-0180

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Sulforaphane exerts anti-angiogenesis effects against hepatocellular carcinoma through inhibition of STAT3/HIF-1α/VEGF signalling

Autor: Sophia Akbareian, Zhigang Zhou, Stephen D. Robinson, Peng Liu, Samuel J. Atkinson, Andrea Münsterberg, Yongping Bao

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports

Angiogenesis plays an important role in hepatocellular carcinoma (HCC), the inhibition of which is explored for cancer prevention and treatment. The dietary phytochemical sulforaphane (SFN) is known for its anti-cancer properties in vitro and in vivo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::768a17fc2317a07c444fe032be235a7f
https://ueaeprints.uea.ac.uk/id/eprint/64912/

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