Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Sophia A. Ward"'
Publikováno v:
Animals, Vol 14, Iss 2, p 224 (2024)
Tail biting (TB) in pigs is a complex issue that can be caused by multiple factors, making it difficult to determine the exact etiology on a case-by-case basis. As such, it is often difficult to pinpoint the reason, or set of reasons, for TB events,
Externí odkaz:
https://doaj.org/article/5d4375742edf493cbd61fbd1e618aff5
Publikováno v:
Animals, Vol 12, Iss 7, p 847 (2022)
The inflammatory pain and stress some crated sows experience during farrowing has attendant risks of piglet-directed aggression, reduced teat exposure and hindered post-partum recovery. To counter this, the steroidal anti-inflammatory compound, dexam
Externí odkaz:
https://doaj.org/article/d838515e99e54c97be9f388c448cc52c
Autor:
Sophia A. Ward, Roy N. Kirkwood, Kate J. Plush, Sadikalmahdi Abdella, Yunmei Song, Sanjay Garg
Publikováno v:
Pharmaceutics, Vol 14, Iss 2, p 340 (2022)
The swine industry has evolved significantly in the recent decades, but this has come at considerable expense to piglet survival. Breeding sows for greater prolificacy has been accompanied by a greater proportion of piglets being born underweight, of
Externí odkaz:
https://doaj.org/article/b59e80a50311447d890d583771fbcd87
Publikováno v:
Animals, Vol 10, Iss 2, p 309 (2020)
As sows continue to be selected for greater prolificacy, it is important to review problems that arise in larger litters, and whether these issues can be appropriately managed. Although a proportion of piglets in larger litters can be born underweigh
Externí odkaz:
https://doaj.org/article/1f93aa1322904a7ca4889afaa2ff5b10
Autor:
Daniel M. Maloney, Naomi Chadderton, Sophia Millington-Ward, Arpad Palfi, Ciara Shortall, James J. O’Byrne, Lorraine Cassidy, David Keegan, Peter Humphries, Paul Kenna, Gwyneth Jane Farrar
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Optic Atrophy 1 (OPA1) is a mitochondrially targeted GTPase that plays a pivotal role in mitochondrial health, with mutations causing severe mitochondrial dysfunction and typically associated with Dominant Optic Atrophy (DOA), a progressive blinding
Externí odkaz:
https://doaj.org/article/4b299d0b315044cd94b2e4bfd9480a83
Autor:
Naomi Chadderton, Arpad Palfi, Daniel M. Maloney, Matthew Carrigan, Laura K. Finnegan, Killian S. Hanlon, Ciara Shortall, Mary O’Reilly, Peter Humphries, Lorraine Cassidy, Paul F. Kenna, Sophia Millington-Ward, G. Jane Farrar
Publikováno v:
Pharmaceutics
Volume 15
Issue 2
Pages: 322
Volume 15
Issue 2
Pages: 322
AAV gene therapy for ocular disease has become a reality with the market authorisation of LuxturnaTM for RPE65-linked inherited retinal degenerations and many AAV gene therapies currently undergoing phase III clinical trials. Many ocular disorders ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d20be50a6905cf899fae767a6a7756
Autor:
Matthew Carrigan, Sophia Millington-Ward, Laura K. Finnegan, Peter Humphries, G. Jane Farrar, Megan Berkeley, Killian S. Hanlon, Naomi Chadderton, Paul F. Kenna, Arpad Palfi
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
Retinal ganglion cells (RGCs) are known to be involved in several ocular disorders, including glaucoma and Leber hereditary optic neuropathy (LHON), and hence represent target cells for gene therapies directed towards these diseases. Restricting gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04d350556f1f57cb4d5501926abf6cc
http://link.springer.com/article/10.1038/s41598-020-73257-z
http://link.springer.com/article/10.1038/s41598-020-73257-z
Autor:
Sophia Millington-Ward, Naomi Chadderton, Laura K. Finnegan, Iris J. M. Post, Matthew Carrigan, Rachel Nixon, Marian M. Humphries, Pete Humphries, Paul F. Kenna, Arpad Palfi, G. Jane Farrar
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 4
Pages: 3847
Volume 24
Issue 4
Pages: 3847
Age-related macular degeneration (AMD) is the most common cause of blindness in the aged population. However, to date there is no effective treatment for the dry form of the disease, representing 85–90% of cases. AMD is an immensely complex disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::366cae23e0fa92f6d25ab28856e5635c
https://doi.org/10.3390/ijms24043847
https://doi.org/10.3390/ijms24043847
Autor:
Laura K. Finnegan, Naomi Chadderton, Paul F. Kenna, Arpad Palfi, Michael Carty, Andrew G. Bowie, Sophia Millington-Ward, G. Jane Farrar
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 3; Pages: 1606
International Journal of Molecular Sciences, Vol 23, Iss 1606, p 1606 (2022)
International Journal of Molecular Sciences, Vol 23, Iss 1606, p 1606 (2022)
The challenge of developing gene therapies for genetic forms of blindness is heightened by the heterogeneity of these conditions. However, mechanistic commonalities indicate key pathways that may be targeted in a gene-independent approach. Mitochondr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::735b4c2edf8e41ea75c59c7ec99d84f4
Autor:
Sophia Millington‐Ward, Naomi Chadderton, Laura K. Finnegan, Iris J.M. Post, Matthew Carrigan, Tom Gardiner, Elisa Peixoto, Daniel Maloney, Marian M. Humphries, Alan Stitt, Thierry Léveillard, Pete Humphries, Paul F. Kenna, Arpad Palfi, G. Jane Farrar
Publikováno v:
Clinical and Translational Medicine
Millington-Ward, S, Chadderton, N, Finnegan, L K, Post, I J M, Carrigan, M, Gardiner, T, Peixoto, E, Maloney, D, Humphries, M M, Stitt, A, Léveillard, T, Humphries, P, Kenna, P F, Palfi, A & Farrar, G J 2022, ' AAV-mediated gene therapy improving mitochondrial function provides benefit in age-related macular degeneration models ', Clinical and Translational Medicine, vol. 12, no. 8, e952 . https://doi.org/10.1002/ctm2.952
Millington-Ward, S, Chadderton, N, Finnegan, L K, Post, I J M, Carrigan, M, Gardiner, T, Peixoto, E, Maloney, D, Humphries, M M, Stitt, A, Léveillard, T, Humphries, P, Kenna, P F, Palfi, A & Farrar, G J 2022, ' AAV-mediated gene therapy improving mitochondrial function provides benefit in age-related macular degeneration models ', Clinical and Translational Medicine, vol. 12, no. 8, e952 . https://doi.org/10.1002/ctm2.952
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de0ba68887019dfd9054574032d5da9b